Active Ingredient: Valacyclovir
Valtrex is used for treating shingles (herpes zoster), cold sores (fever blisters or herpes labialis), and treating, suppressing, or reducing transmission of genital herpes in patients with normal immune systems.
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Valtrex – an antiviral drug, the main active substance is valaciclovir. The medicament exhibits activity against viruses of herpes zoster, human herpesvirus 6, herpes simplex virus types 1 and 2, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus. After absorption in the gastrointestinal tract by enzymes in the liver drug becomes valine and acyclovir. Acyclovir is built into the DNA chain of the virus, thereby cease DNA synthesis and blocks reproduction (replication) of the virus.Acyclovir is built into the DNA chain of the virus, thereby cease DNA synthesis and blocks reproduction (replication) of the virus.When immunocompetent patient rarely (less than 0.1%) found a reduced sensitivity of herpes simplex and herpes zoster to valacyclovir. In patients with severe immune disorders (for HIV infection, chemotherapy or bone marrow transplant) decrease in susceptibility to the drug more common – this is due to mutation of the virus and a violation of the structure of the viral DNA.Since proteins in the blood binds only 15% Valtrex. Valacyclovir is derived from the body in urine. The half-life of the drug is 3 hours, renal insufficiency – about 14 hours, which may lead to increased concentrations of the drug in the body.
Instructions for use Valtrex:
With the purpose of treatment Valtrex is used for such diseases: herpes zoster (shingles) reduces the severity and duration of pain in the acute stage and neuralgia after herpes; herpetic infection of mucous and skin caused by herpes simplex type 1 and 2 (including herpes of the lips and genital herpes); use of the drug in the early stages of the disease breaks.
From prevention to Valtrex is prescribed: for the prevention of exacerbations of herpes simplex virus (type 1 and 2), genital herpes; to reduce the risk of infection of the sexual partner genital herpes (in combination with safer sex admission); to prevent opportunistic infections (herpes simplex, cytomegalovirus infection, herpes zoster) and reducing rejection in organ transplants in adults and children after 12 years.
Contraindications:Individual intolerance to the drug or its components; chronic renal failure.
How to take Valtrex?
Valtrex pills is independent of food intake. Medicine washed down with water. Elderly patients and those with risk of dehydration should ensure that excessive drinking. Professional restrictions (transport management and work with dangerous equipment) during treatment Valtrex no.
The dosage of Valtrex
When herpes zoster Valtrex is usually used at a dose of 1 g 3 p. per day for a week. Herpes infection, herpes simplex virus type 1 and 2 in the acute period of 7 days is treated Valtrex 500 mg 2 p. per day. At relapse of the disease – a course usually lasts 5-10 days, and the treatment should be started at the slightest manifestations of the disease as early as possible.Alternative treatment of herpes of the lips on the first day of Valtrex appointed 2 g 2 p. per day at 12 hour intervals. The drug should begin at the first sign of illness (burning, itching on the lip). For the prevention of recurrence of the disease (with normal immunity) receiving 500 mg 1 p. per day, and with frequent exacerbations (10 p. for a year or more) – 250 mg 2 p. per day. If immunodeficiency is dosed at 500 mg 2 p. per day.
The duration of treatment of 4 to 12 months.For the prevention of genital herpes have healthy sexual partner with normal immunity, it should take 500 mg of Valtrex 1 p. per day. Daily intake of the drug spend a year or more, if you have sex regularly, and at irregular – treatment is initiated 3 days prior to sexual intercourse. When an organ transplant in adults and adolescents after 12 years for the prevention of viral infections and rejection prescribed Valtrex as possible in the early postoperative period at a dose of 2 g 4 p. per day.
In chronic renal failure dose chosen physician individually depending on the creatinine clearance. Such patients need regular medical supervision, as they often develop complications of the nervous system. With hemodialysis Valtrex appointed after the meeting. Patients with liver disease, especially in severe cirrhosis of the liver, high dose Valtrex used with caution.
If overdose occur disorders of the digestive system (nausea, vomiting) and neurological disorders (headache, disturbance of consciousness, hallucinations) and may develop acute renal failure. Effective in this case is hemodialysis.
Clinical Research on the use of Valtrex in children are not available. At the age of children under 12 years Valtrex is not applicable. Children 12 years after Valtrex assigned only for the prevention of viral infections (including CMV) and reduce the rejection reaction after organ transplantation. For all other indications Valtrex under 18 is not assigned.
Valtrex in pregnancy and lactation
Clinical safety data on the use of Valtrex in women during pregnancy is not enough, and they are not statistically significant. The preparation is allowed to apply only in cases where the therapeutic effect of the drug outweigh the risks for pregnant possible effects on the fetus. In experimental animal studies, teratogenic effects on the fetus Valtrex is not revealed. Given that Valtrex passes into breast milk, the drug may have effects on the child’s body. Prescribers women, breastfeeding should be cautious.
Store Valtrex between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Valtrex out of the reach of children and away from pets.
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