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Other names for this medication:Aramix, Celtium, Cipralex, Citoles, Citraz 5, Dexapron, E-zentius, Ectiban, Entact, Escitalopramum, Escitaloprim, Esertia, Esipram, Esita, Esital, Eslorex, Esram, Gaudium, Ipran, Lexamil, Lextor, Losiram, Losita, Meliva, Meridian, Neozentius, Nexcital, Oxapro, Seroplex, Sipralexa, Starcitin es, Tiopram.

Composition
The composition of the preparation is equivalent to three basic forms of release from the mass calculation for one tablet of the active substance of oxalate escitalopram – 6.39 / 12.77 / 25.54 mg:
Fine crystalline cellulose (MCC) – 72.49 / 97.49 / 195 mg;
Talcum ordinary 5.04 / 7/14 mg;
Sodium croscarmellose – 3.24 / 4.5 / 9 mg;
Magnesium stearate – 0.9 / 1.25 / 2.5 mg.
The film membrane of the tablets is an important component of the preparation of Cipralex. It consists of:
Hypromellose 5cP – 1.58 / 2.19 / 3.51 mg;
Titanium dioxide (E171) – 0.526 / 0.73 / 1.17 mg;
Macrogol 400 – 0.146 / 0.2 / 0.325 mg.

Form of issue
The preparation is issued in the form of round or oval biconvex tablets of white color, covered with a film membrane with various dosage:
5 mg of the active ingredient (“EC” label) – in a contoured cell package (usually aluminum foil or PVC) 14 tablets, in a carton 2 packs.
Cipralex 10 mg (symmetric marks “E” and “L” relative to the risks on one of the surfaces) – in the blister 14 tablets, 1, 2 or 4 contours in the box.
20 mg of the biologically active component (labeling “E” and “N” on either side of the dash on one side of the tablet) – in the box there are 2 blisters with 14 filled cells.

Pharmacological action
Cipralex refers to the pharmacological group of potent antidepressants. Due to the biologically active substance, which has an affinity for the allosteric center of the serotonin transfer enzyme, the drug inhibits the reuptake of the neurotransmitter in synaptic structures (the drug has a greater effect on the metabolic pathways of serotonin than on any other messengers). Accordingly, the physiological pulse transmitter is located in the synaptic gap of the neuronal contact for a longer period of time, which causes the enhanced, prolonged action of the postsynaptic membrane.
It should be noted that the drug is strong and long-acting, as it binds in two places with the serotonin transfer enzyme. First of all, the main active ingredient has a high affinity for the primary amino acid sequence of the transporter protein. Also, the components of the Cipralex bind to the allosteric center of the molecule, which again increases the effect of the drug, that is, leads to a more complete inhibition of the reuptake of the neurotransmitter.

Cipralex shows little activity towards such receptors as:
➠Serotonin 5-HT1A and 5-HT2;
➠Dopamine D1 and D2;
➠Alpha and beta adrenergic synapses;
➠Histamine H1 receptor cells;
➠Opioid and benzodiazepine;
➠M-holinoretseptory.

Pharmacodynamics and pharmacokinetics
Absorption of the active ingredients does not depend on the intake of food, since the drug is an extremely strong pharmaceutical preparation. Absolute bioavailability is about 80 percent, and the average half-life is 4 hours (however, the parameter can vary depending on individual body parameters and environmental conditions).

LEXAPRO is metabolized in the liver. The constituent elements of the preparation even after oxidation remain biologically active and undergo certain changes in metabolic processes in the form of glucuronides. The metabolites are then sent to the kidneys, which excrete waste drug residues through urine. Clearance with oral administration of the drug is 0.6 l / min.
The kinetics of escitalopram oxalate is described linearly. Equilibrium concentrations in the systemic blood stream, with a daily dose of 10 mg (the optimal amount of active ingredient for an adult), is achieved after one week of a conservative course of treatment with LEXAPRO.
In elderly patients (over 65 years of age), the pharmacological drug is somewhat slower. Clinical trials have shown that during the therapeutic dose, after a single dose of Zipraplex, the amount of active component in the systemic bloodstream of the elderly is 50 percent greater than that of young volunteers.

Indications for use
LEXAPRO is recommended to be included in the conservative treatment regimen if neurological pathologies such as:
➣Long periods of depression of any severity;
➣Panic disorders (which can be explained by agoraphobia – fear of open spaces);
➣Depressive stage of manic-depressive psychosis;
➣Various kinds of social phobias or just anxiety among people;
➣Obsessive-compulsive disorder (medical explanation of “obsession with the idea”);
➣Obsessive-compulsive disorder;
➣Syndrome of generalized anxiety.

Contraindications
From the pharmacological treatment of LEXAPRO should be abandoned when:
Hypersensitivity or intolerance to the constituent components of the drug;
Childhood and adolescence (the therapeutic course is not recommended to be performed until age 18);
Simultaneous sanation with monoamine oxidase inhibitors (antidepressants) or pimozide (antipsychotic medications);
Acute or chronic renal failure with creatinine clearance below 30 ml / min;
Epilepsy, which is not controlled by pharmacological agents.
Take Cipralex only under the supervision of qualified medical personnel in one of the following situations:
Insulin-independent diabetes mellitus (type I necessarily shows consultation with an endocrinologist);
elderly age;
Cirrhosis, acute or chronic liver failure;
Tendency to frequent hemorrhages due to insufficiency of the blood coagulation system;
Hereditary and acquired metabolic diseases.

Side effects
Cipralex is a strong drug, because its effect can be characterized by a large number of unwanted reactions from the body. So, for example, are noted:
☞ Dyspeptic disorders (nausea, vomiting, diarrhea, abdominal pain);
☞ Asthenic syndrome (insomnia ordeal, headache, constant fatigue, dizziness);
☞ Metabolic disorders in the form of sweating, hyperthermia and hyponatremia;
☞ Thrombocytopenia and, as a consequence, insufficiency of the blood coagulation system;
☞ Orthostatic collapse or hypotension;
☞ Decrease in reproductive function (decreased libido and potency, both in men and women);
☞ Allergic reactions (a range of undesirable effects affect the manifestations of angioneurotic edema of Quincke, down to anaphylactic shock);
☞ Arthralgia and myalgia of idiopathic genesis, which are not related to the load on the joints or muscles;
☞ Skin rash, purpura, ecchymosis.
It should be noted that the adverse effects of treatment usually occur during the first or second week of the conservative therapeutic course and significantly decrease in manifestations if the sanation is continued according to the plan.
Since the drug belongs to the list of B pharmacological products, then with a sharp discontinuation of Zipraplex after long-term treatment with the drug, withdrawal syndrome is possible. That is, the body lacks an active active substance. This manifests itself in the form of severe headache, irritability, nausea and frequent dizziness.

Instructions for the use of Zipraplex (Method and dosage)
The use of LEXAPRO does not depend on meals a day. The duration and intensity of the course of conservative treatment largely depends on the initial disease:
So to achieve an antidepressant effect, shock doses are used for 2-4 weeks (10 mg of Zipraplex per day for an adult patient) and the next 6 months of maintenance therapy to consolidate the results.
The instructions for Cipralex in panic disorders are very different – they begin pharmacological therapy with 5 mg of the drug with a further increase in the daily dose to 10 mg. Depending on the individual reaction of the body, the amount of the drug can be increased to 20 mg per day. The maximum effect is achieved after 3 months, however, sanation can last up to six months.
In patients with renal or hepatic insufficiency (both acute and chronic), but with absolute indications for the use of LEXAPRO, the maximum single dose is 5 mg. The increase is not recommended, but if the desired therapeutic effect is not achieved, the amount of the drug administered is doubled.

Overdose
In clinical practice cases of overdose of Zipraplex are known, which usually manifest themselves as follows:
☞ Darkened consciousness, confusion;
☞ Tremor of extremities, violation of fine motor skills;
☞ Convulsive seizures;
☞ Agitation (a strong emotional excitement, which is accompanied by a sense of anxiety and an unreasonable need for movement);
☞ Significant changes in the electrocardiogram (expansion of the ventricular complex, depolarization of the depolarization segment);
☞ Arrhythmias by type of tachycardia;
☞ Metabolic acidosis, hypokalemia;
☞ Oppression respiratory function of the respiratory system.
There is no specific antidote or antagonist of Zipraplex, so the overdose treatment is based on symptomatic and palliative care to the patient. First of all, you should wash the stomach, in order to evacuate from the body are not absorbed the remains of the pharmaceutical product. Further, it is necessary to ensure sufficient oxygenation and constant monitoring of the vital systems of the human body.

Interaction
It is strictly prohibited simultaneous application of LEXAPRO and drugs that irreversibly inhibit monoamine oxidase, as the percentage of development of severe side effects increases several times (the percentage of respiratory or heart failure is statistically increased).
Based on pharmacological studies, it is not recommended to include in the course of treatment of cipralex and reversible MAO inhibitors because of the risk of serotonin syndrome (potentially deadly situation).
Do not use the drug with escitalopram in parallel with anticoagulants or drugs that reduce blood clotting, as this can lead to severe hemorrhagic syndrome and anemia, as an outcome of the pathological situation, which will complicate the patient’s treatment.
There are a number of pharmaceuticals that interact with the allosteric centers of carrier proteins to increase the activity of Cipralex. For example, omeprazole (against ulcer drug) leads to an increase in the concentration of active substance in the systemic circulation twice, and cimetidine (the blocker of H2-histamine receptors, which is prescribed in the pathology of the gastrointestinal tract) – by 70%.
Serotonin reuptake inhibiting agents, and Cipralex, as a typical representative of this pharmacological group, reduce the threshold of convulsive activity, that is, tremor and / or convulsive syndrome may manifest itself to less intense stimulation. This action will be potentiated if Cipralex and other strong antipsychotics (neuroleptics) are taken concomitantly, for example, Tramadol, Phenothiazine, Butirofenone, and so on.

Storage conditions
The drug should be stored in a warm, dry place, inaccessible to children of all ages and direct rays of light at a temperature of no higher than 25 degrees Celsius.

Shelf life
3 years.

Special instructions
Cipralex does not exert a depressing effect on the intellectual or psychomotor sphere of the patient, however, while continuing the course of conservative treatment, it is recommended to refuse driving the car or controlling technical devices that require a long concentration of attention and fine motor skills.
The drug can contribute to a change in the concentration of glucose (a significant increase in it) and insulin (a relative decrease in the hormone) in the systemic blood stream, and accordingly this treatment requires a certain correction of hypoglycemic agents in patients with diabetes mellitus.
Therapy with antidepressants can lead to suicidal thoughts in the early stages of the sanation course. Increased risk of self-injury, suicidal tendencies remain until the remission of the underlying disease, therefore, conservative treatment with LEXAPRO should be carried out in special departments under the supervision of qualified medical personnel.

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26.01.2015 | | Bestsellers, Male health, Women's Health

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Active Ingredient: Azithromycin
Zithromax is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. In children, it is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

 Product description

INDICATIONS

Zithromax is used for treating mild to moderate infections caused by certain bacteria. It may also be used alone or with other medicines to treat or prevent certain infections in persons with advanced HIV infection. Zithromax is a macrolide antibiotic. It slows the growth of, or sometimes kills, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

INSTRUCTIONS

Use Zithromax as directed by your doctor.

  • Take Zithromax by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Zithromax.
  • Zithromax works best if it is taken at the same time each day.
  • To clear up your infection completely, use Zithromax for the full course of treatment. Keep using it even if you feel better in a few days.
  • If you miss a dose of Zithromax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zithromax.

STORAGE

Store Zithromax below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zithromax out of the reach of children and away from pets.

Active Ingredient: Azithromycin.

Safety information

Do NOT use Zithromax if:

  • you are allergic to any ingredient in Zithromax, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin)
  • you are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zithromax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:if you are pregnant, planning to become pregnant, or are breast-feedingif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplementif you have allergies to medicines, foods, or other substancesif you have liver or kidney problems, myasthenia gravis, or abnormal heart rhythms.Some medicines may interact with Zithromax. Tell your health care provider if you are taking any other medicines, especially any of the following:Antiarrhythmics (eg, disopyramide, dofetilide ), arsenic, astemizole, cisapride, domperidone, maprotiline, methadone, paliperidone, pimozide, propafenone, quinolone antibiotics (eg, levofloxacin), terfenadine, or tetrabenazine because the risk of heart problems, including irregular heartbeat, may be increased Nelfinavir because it may increase the risk of Zithromax’s side effectsRifampin because it may decrease Zithromax’s effectivenessAnticoagulants (eg, warfarin), carbamazepine, cyclosporine, digoxin, ergot derivatives (eg, ergotamine), nilotinib, phenytoin, rifampin, theophylline, triazolam, or tyrosine kinase receptor inhibitors (eg, dasatinib) because the risk of their side effects may be increased by Zithromax.This may not be a complete list of all interactions that may occur. Ask your health care provider if Zithromax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

    • Zithromax may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zithromax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
    • Zithromax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zithromax. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
    • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
    • Tell your doctor or dentist that you take Zithromax before you receive any medical or dental care, emergency care, or surgery.
    • Long-term or repeated use of Zithromax may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
    • Be sure to use Zithromax for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
    • Zithromax only works against bacteria; it does not treat viral infections (eg, the common cold).
    • Zithromax should not be used in children; safety and effectiveness in children have not been confirmed.
    • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zithromax while you are pregnant. It is not known if Zithromax is found in breast milk. If you are or will be breast-feeding while you use Zithromax, check with your doctor. Discuss any possible risks to your baby.
    • Side effects

  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Diarrhea; headache; loose stools; nausea; stomach pain; upset stomach; vomiting.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; changes in hearing or hearing loss; chest pain; eye or vision problems; irregular heartbeat; muscle weakness; pounding in the chest; red, swollen, blistered, or peeling skin; ringing in the ears; seizure; severe diarrhea; stomach cramps/pain; trouble speaking or swallowing; yellowing of the skin or eyes.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

26.01.2015 | | Bestsellers, Health of children, Male health, Women's Health

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tadapox

Analog.

Active substance: Tadapox
Cialis Super Power 2 includes a part of the active substance – tadalafil 20 mg (struggling with erectile dysfunction) and Dapoxetine 60 mg (prolongs intercourse 3-4 times). 2 basic substances are selected in perfect proportion that does not require the purchase of each drug separately.
Cialis Super Power – solves both problems!
Take 1 tablet 20 minutes before sexual intercourse. Effective preparation is 36-48 hours. Cialis Super Power improves potency, speeds up recovery after each orgasm, improves blood circulation in the penis. This drug – a new tool that solves 2 problems (premature ejaculation and impotence). It is also to avoid a situation where the presence of persistent erection during sex excitement disappears, since the stimulation and good circulation, this problem is eliminated as though it never existed.

Age:
The drug can be taken at any age (over 18 years).

Contraindications:
Do not take more than one pill per day.
When the drug begins to act
The action starts with the sexual arousal. As soon as it boils down to nothing, the penis returns to a relaxed state.

Shelf life
We only have a maximum shelf life.
Who produces Super Power?
Super Tadarise produced in factories Sunrise Remedies Pvt. The tablets have a diamond shape. A TADAPOX – Delta Enterpises go round shape yellow.

Overdose, what to do?
At the use of a considerable number of tablets wash the stomach or invoke vomiting after taking at least 1 cup of water.

What a time to receive optimal?
It is recommended to take 1 pill 1 hour before sex. The tablet should be swallowed without raskusyvaya with water. If the drug is not given a good extension of the sexual act, then increase the time up to 2 hours.
Is not it dangerous to health?

No, as pharmaceuticals and normal dosing does not cause any pathologies also:
➲ Does not alter the composition of the sperm;
➲ Does not reduce the level of testosterone;
➲ Is rapidly excreted from the body.

What is different from analogues
From their counterparts different duration of action is up to 36 hours.

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Analog.

Silvitra 120 mg (active ingredient – Sildenafil 100 to vardenafil 20 mg) tablets new safe Silvitra – the drug, which included just two predominant popular ingredient used to manufacture Viagra and Levitra.

Duration: 12:00.
Admission: 20-25 minutes before sexual intercourse.
Alcohol: I suppose in minimum quantities.
Recommended daily dose: not more than 1 tablet.

Modern scientists regularly conduct research and introduce the latest developments in chemical preparations for preserving and increasing male potency. The main purpose to cause and how to fix a longer period of strong erection. One of these innovations and become drug Silvitra.

Advantages of the drug:

☛It felt the impact of the drug within 25 minutes after ingestion;
☛Silvitra enhances blood circulation in the pelvic organs;
☛mild effect of the drug is almost no side effects;
☛symbiosis of the two best active ingredients, can cope with even the most “neglected” diseases of the male;
☛excitation mechanism is triggered only when a natural sexual stimulation;
☛increased duration of erections in 2-3 times;
☛reduces the amount of time between sexual acts, that is already half an hour after intercourse man is once again ready to continue lovemaking.
Aphrodisiac Silvitra very popular among males, leading an active life and aspiring to sexual diversity.

International name: Silvitra 120 mg.
Pharmacological group: PDE 5 inhibitor (PDE-5).
Active substance: Sildenafil Vardenafil 20mg 100mg.
Dosage form: oval tablets, coated yellow.

Pharmachologic effect
Each tablet contains 100 mg Nitre sildenafil and 20 mg vardenafil. Regardless of the cause of impotence, sildenafil helps to achieve full sexual arousal. Vardenafil is rapidly dissolved in the blood and spreads throughout the body.

Indications
The drug is prescribed to treat erectile dysfunction and improve the quality of sexual life. With two active substances, which increase blood flow to the penis, Silvitra helps to cope with the problems caused by the man’s psychological factors, stress and fatigue, problems with the endocrine system and vascular disease.

Mode of application
At night you can eat no more than 120 mg Silvitra (one tablet). Take the medicine on an empty stomach is better for half an hour before the planned sexual intercourse. Its effect is maintained for at least 24 -30 hours, if not abuse of fatty foods and alcohol.

Contraindications
☛stomach cancer and other cancers;
☛allergic to one or more active ingredients;
☛cardiac disease character;
☛chronic diseases of the gastrointestinal tract;
☛deformation of the sexual organs.

Side effects:
☑migraine;
☑dizziness;
☑diarrhea;
☑nasal congestion.

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Analog.

Characteristics:

Each tablet contains 100 mg of sildenafil.

Duration: 4-6 hours.

Onset of action: After 30-40 minutes.

Active substance: Sildenafil (Sildenafil).

Description: Designed to address female sexual desire disorder and female sexual dysfunction. Created to satisfy the sexual needs and prolong pleasure.

Dosing: Action female Viagra begins 30 minutes after administration and lasts for a minimum of 4 hours. Most patients can take Female Viagra daily.

Female Viagra – the first generic, designed specifically for women. This drug helps to enhance libido, to fully enjoy the sexual life and contributes to obtaining orgasm. The active ingredient – Sildenafil. Generic comes in tablet form with a pink envelope.

Indications
• Reduced sex drive.
• No response to stimulation.
• Discomfort during intercourse due to dryness and the lack of excitement.
• Sexual dysfunction.
• menopause.

The action of the drug
Female Viagra – a very effective generic, helps to restore normal physiological characteristics of the female body in sexual terms. After the drug returns natural lubrication and swelling of the labia, the clitoris is enhanced sensitivity. And all of these functions back on when there is sexual stimulation and without addiction to generic.
Tablets enhances the feeling directly during intercourse and orgasm strength. Women of all ages, to test female Viagra, noted the positive sensations of sexual contact, even if they previously had difficulty reaching orgasm. This is achieved thanks to sildenafil, which is an inhibitor of PDE-5. His action of this substance improves blood circulation of the vascular system in the pelvis. It has beneficial effects on the smooth muscle of arteries leading to the natural swelling of the labia minora and clitoris
In addition, the generic functionality improves the mucous glands, whereby the lubricant is released in the vagina. Such effects of the drug on the body eliminates the problem of dryness and discomfort during intercourse. The effect of one tablet lasts up to 5 hours. So, enjoy a full sex life and get maximum pleasure can any woman, even in the period of menopause.

Instructions for use
The drug is used to enhance libido in about 40-60 minutes prior to prospective sexual intercourse. Once the active ingredient gets into the bloodstream, it will work effectively in the next 5 hours. The optimum daily dose – 100 mg. You can start taking pills to 25-50 mg per day. If Generic Female Viagra is well absorbed by the body, but does not give the maximum effect, the daily dose increased to 100 mg. It is not desirable to increase the dose. If necessary, consult a doctor. Tablets can be taken no more often than once per day.

Contraindications

Generic Female Viagra should not be taken during pregnancy and lactation, and in the following diseases:
• rhythm disorders, and other cardiovascular diseases.
• Anemia.
• Hypertension.
• Oncological diseases.
• Problems with kidney or liver.
• Stroke, heart attack or heart attack, brought over the last year.

If the first reception of pills cause an allergic reaction, you must stop it and consult a physician.

As generic interacts with other medications?
With regular use of any other drugs, it is desirable to consult with your doctor. As a general rule, the specialist ban take Female Viagra in combination with nitrate or nitrite drugs. For example, nitroglycerin, Nitrosorbid etc. It is impossible to combine the generic with poppers.
If you start taking Viagra for women with the above drugs, the problem can start with pressure, and heart, until a stroke or heart attack.

Possible side effects

Testing generic found that a side effect of the drug is minimized. In rare cases, can be observed the following reactions:
• Vomiting and nausea.
• Vertigo.
• redness of the face.
• Chest pain and headaches.
• Indigestion.

Storage conditions
Viagra for women should be stored out of reach of pets and small children at room temperature. Expiry date is indicated on each blister.

Efficacy
Female Viagra allows you to be more sensitive to sexual stimulation and affection. The product provides maximum pleasure from intimate process that helps women improve their health and improve your mood. This is especially important for older women who are or have been through a difficult period of menopause.
However, it is understood that the female Viagra – the drug exclusively for women. Its composition is specially designed for the female body, so taking this drug should be strictly in accordance with your gender. For men developed many other medicines that can successfully deal with erectile dysfunction.

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26.01.2015 | | Bestsellers, Women's Health

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Analog.

Active Ingredient: tadalafil sildenafil citrate
Sildalis is a combination drug, consisting both of Tadalafil and Sildenafil citrate. This combined medication is designed for the treatment of the sexual dysfunction in men.

Description Sildalis drug

The most effective and relatively safe medications for the restoration of the normal Viagra potency are considered, the main component of which is a chemically synthesized substance sildenafil, and Cialis that contains Tadalafil. The action of these drugs is largely identical, but doctors ratings show that the effect of tadalafil lasts more than 24 hours.
But scientists did not stop there, and as a result of many years of hard work and a number of clinical trials have been developed a new drug – Sildalis. It includes and tadalafil, and sildenafil in different concentrations. This provides a sufficiently rapid and prolonged drug efficacy. In addition, its price is significantly lower than the mentioned analogues.

Operating principle
To understand how “works” Sildalis, you must briefly refer to the appearance of erection physiology. In response to sexual stimulation begins a series of hormonal and enzymatic reactions in the male genital organs. The result is a cyclic guanosine monophosphate or abbreviated – cGMP. This enzyme relaxes the muscle tissue of the corpus cavernosum, which occupy most of the inside of the penis. They are filled with arterial blood, and increase in size, providing an erection.
After intercourse cells corpus cavernosum has been operating for another enzyme – phosphodiesterase (PDE). This material is not only in the genital organs, it is present in almost all cells of the body. On the internal tissues of the penis affects a specific type of PDE fifth, which destroys cGMP.

As a result, the process is reversed: the outflow of blood from the penis is reduced, and it acquires previous size.
Reviews of researchers suggest that the effect of sildenafil and tadalafil, which are part of Sildalis tablets are intended to selectively inhibit the enzyme PDE-5. The result is a fairly prolonged erection for normal sexual intercourse.
But all of these physiological processes are under the control of the brain. Therefore Sildalis not help in the absence of libido or sexual arousal. If a man does not feel sexual attraction to the opposite sex, then it is most likely indicative of hormonal disorders and requires treatment appropriate drugs.

Route
The main indication for the use Sildalis capsules is erectile dysfunction. Reviews of doctors tell in detail about the causes of disorders of potency. Only in 20% of cases, this problem is caused by psychological factors, stress and fatigue. In most cases the cause are:
➤Cardiovascular diseases associated with impaired circulation.
➤Endocrine diseases, in most cases – diabetes.
➤Infectious and inflammatory diseases of the genitourinary system.
➤Hormonal disorders.
➤Age-related changes in an organism.
➤Taking certain medications.

Instructions for use states that Sildalis be effective in almost all these cases. Feedback from customers has never talked about the ineffectiveness of these tablets, which is a huge advantage, especially considering that the price is relatively low.
Instructions for use describes in detail how to take these pills. Reviews of researchers say that the effect of the drug begins after 15-20 minutes, but the doctor advised to take Sildalis 30-40 minutes before intercourse. Upon receiving means normally retained its effectiveness to 36 hours. It consists of 100 mg of sildenafil and tadalafil 20 mg. This is a fairly high dose of active ingredients, so more than one capsule is not recommended to take a day.

As mentioned above, the PDE enzyme is present not only in the tissues of the penis. Although Sildalis has a sufficiently high selectivity, it is also to varying degrees and can affect the action of phosphodiesterase in other organs. Reviews of researchers argue that it is linked to the side effects of medication.

Instructions for use refers to such possible complications after taking the capsules:
➤Headache, dizziness.
➤Shortness of breath, heart palpitations.
➤Fluctuations in blood pressure.
➤Sleep disturbances, increased nervous irritability.
➤Allergic reactions on the skin.
➤Violation of color vision, blurred vision.
➤Muscle pain in the back.
➤The emergence of uncontrolled erection unrelated to sexual arousal.
However, in most cases, these side effects are observed in the presence of concomitant diseases of the cardiovascular system, liver or kidneys. This suggests that one should visit the district physician before using the drug.

Precautionary measures
Most Sildalis contraindications to capsules not so much related to the impact of the drug on the body components, but with limitations for increased sexual activity due to various diseases. For instructions on the use of this medication is not recommended to take it in the following cases:
➤The first 6 months after suffering a heart attack or stroke.
➤Too high or, conversely, reduced blood pressure,.
➤Severe heart failure, heart rhythm disorders.
➤Regular bouts of migraine, epilepsy.
➤Severe renal and hepatic failure.
➤Gastric ulcer during the exacerbation.
➤Hypersensitivity to the drug.

^Also, this drug is strictly prohibited to take along with medicines containing nitrogen compounds. Some antibiotics, such as rifampicin and erythromycin, slow clearance between the active components of the drug from the body, so in this case the required dosage reduction.^
It is worth noting that high-fat foods can slow the onset of action of tablets, and the excess of alcohol increases the risk of complications of the cardiovascular system. Furthermore, even if you are sure that there are no contraindications at the reception of these capsules, it is still in front of the reception is necessary to consult a doctor.

Сost of
In the pharmaceutical market, the drug appeared for a long time, so it can be easily purchased without a prescription the doctor at any pharmacy or online store. The price depends on the number of tablets in the package, the more of them – the value of one capsule below.

^Just one tablet ensures stable and erection long enough sex for at least a day.^

26.01.2015 | | Bestsellers, Male health

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Buy Advair Diskus (Adoair) online

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advair diskus

Analog: Asthma.

Name: Seretide Discus

Pharmachologic effect

Advair Diskus is an antiasthmatic combined preparation. Advair Diskus contains salmeterol and fluticasone.
Salmeterol is a long-acting selective beta2-adrenoceptor. Salmeterol effectively prevents the development of bronchospasm, inducted with histamine. The action of salmeterol lasts up to 12 hours.
Fluticasone propionate is a glucocorticosteroid drug substance. Fluticasone with an inhalation application has a pronounced anti-inflammatory effect on the lungs. Fluticasone provides a reduction in the severity of asthma exacerbation symptoms without the development of undesirable effects characteristic of systemic glucocorticosteroids.

The use of the complex preparation Advair Diskus allows to achieve “good control” and “full control” for the symptoms of asthma more effectively than monotherapy with glucocorticosteroids. When using combination therapy with salmeterol and fluticasone, the level of exacerbations is 29% lower than with monotherapy with glucocorticosteroids.
Advair Diskus reduces the need for rapid bronchodilators, reduces the number of exacerbations of asthma and improves the quality of life in patients with asthma.
In the combined use of salmeterol and fluticasone, the pharmacokinetic profile of these substances is similar to that of a separate application.

Advair Diskus acts locally and, when inhaled, practically does not enter the systemic circulation. Advair Diskus is not cumulated in the body, after 12 months after the start of therapy there is no increase in the plasma level of salmeterol. When using salmeterol xinafoate in the blood plasma, hydroxyanaphthoic acid is determined (the concentration is not more than 100 ng / ml).
Fluticasone propionate is slightly absorbed into the systemic blood stream when inhaled. Absolute bioavailability of fluticasone reaches 10-30%. The rest of the inhalation dose is swallowed, oral bioavailability of fluticasone reaches 1% (due to low solubility of the substance in the water and presystemic metabolism). With increasing doses, there is a linear increase in the systemic effect of fluticasone. The final half-life of fluticasone reaches 8 hours. About 91% of the substance binds to plasma proteins. Fluticasone is metabolized by the cytochrome P450 3A4 system and excreted mainly by the kidneys.

Indications for use
Advair Diskus is used for the regular treatment of reversible obstructive diseases of the respiratory system, including asthma in adults and children (in cases where combined therapy with an inhaled corticosteroid and bronchodilator is required).
Advair Diskus is prescribed to patients receiving effective maintenance doses of selective long-acting beta2-adrenomimetics and inhaled corticosteroids.
Advair Diskus is used in patients who, against the background of monotherapy with glucocorticosteroids, have symptoms of obstructive airway disease, as well as patients receiving bronchodilators who require the appointment of corticosteroids for inhalation.
Advair Diskus can be used as a basic therapy for patients suffering from chronic obstructive pulmonary diseases, including emphysema and chronic bronchitis.

Mode of application
Advair Diskus is intended for inhalation. It is recommended to use Advair Diskus regularly, including during the absence of asthma attacks. In the treatment of reversible obstructive diseases of the respiratory system, sequential regimens should be used and the patient’s condition monitored on a regular basis. At each reception, the prescribed dose should be reviewed and, if possible, reduced (the minimum effective dose of Advair Diskus should be selected). It is forbidden to change the dose of Advair Diskus without consulting a doctor.
For inhalation, you should open and charge the plastic device included in the kit by changing the position of the lever. The mouthpiece is wrapped around the lips, inhaled and closes the device. The dose indicator in the Disk shows the number of remaining doses.

The duration of application and dose of the drug Advair Diskus is determined by the doctor. At the beginning of therapy, as a rule, it is necessary to use the drug twice a day to control the symptoms, after achieving full control of asthma, the drug is used once a day. The amount of fluticasone in the drug is determined by the doctor, given the patient’s condition and the tolerability of the drug Advair Diskus.
With insufficient control of asthma with monotherapy with glucocorticosteroids, the purpose of the drug Advair Diskus allows to achieve an improvement in the condition without increasing the dose of corticosteroids. In patients with good asthma control when using glucocorticosteroid monotherapy, the appointment of Advair Diskus helps to reduce the dose of corticosteroid without loss of effect.

Average recommended doses for patients with reversible obstructive airways disease (including asthma):
Adults and adolescents are usually prescribed 1 dose of Advair Diskus 50 μg / 100 μg or Advair Diskus 50 μg / 25 μg or Advair Diskus 50 μg / 500 μg twice daily. Adults, if necessary, short-term (less than 2 weeks) corticosteroid maintenance therapy may be given 2 doses of Advair Diskus twice a day (safety and tolerability profile will be similar to that for prolonged use of 1 dose of Seretide Diskus twice a day).
Children older than 4 years are usually prescribed 1 dose of Advair Diskus 50 μg / 100 μg twice a day.

Average recommended doses for chronic obstructive pulmonary diseases (including emphysema and chronic bronchitis):
The dose is selected individually. The maximum permissible daily intake for adults is 2 doses of Seretide Diskus 50 μg / 500 μg (divided into 2 doses).
There is no need to adjust the dose of Advair Diskus for patients with impaired renal and hepatic function, as well as elderly patients.

In acute conditions it is necessary to use high-speed bronchodilators. It should be borne in mind that an increase in the frequency of use of high-speed bronchodilators for the relief of acute symptoms indicates a worsening of asthma control.
Progressive and rapid deterioration of asthma control can be potentially unsafe for life. If the prescribed dose of Advair Diskus does not allow you to fully control the symptoms or the number of seizures increases, you should consult your doctor.
The discontinuation of Advair Diskus should be carried out gradually both with short-term therapy and with prolonged use of the drug.
When prescribing Advair Diskus, children and adolescents should regularly monitor growth dynamics.
When switching from oral glucocorticosteroid therapy to inhalation therapy, adrenal function should be monitored.

Side effects
When using Advair Diskus, paradoxical bronchospasm may develop with immediate increase in dyspnea after inhalation. This condition requires immediate application of bronchodilators of fast and short action. After cupping the paradoxical bronchospasm, you should abolish Advair Diskus, examine the patient and prescribe an alternative therapy.

When using Advair Diskus in patients, it is possible to develop unwanted effects caused by fluticasone and salmeterol, including:
From the vessels and the heart: a feeling of palpitation, arrhythmia (including atrial fibrillation, extrasystole and supraventricular tachycardia).
From the nervous system: tremor of the limbs, headache, muscle spasms, sleep disorders, hyperactivity, unreasonable anxiety.
Allergic reactions: urticaria, bronchospasm, angioedema, anaphylactic shock.
others: arthralgia, hyperglycemia.

Possible development of hoarseness, irritation and / or candidiasis of the mucous membrane of the pharynx and oral cavity, the risk of development of which decreases when rinsing the mouth and throat with water after each use of the inhaler. Treatment of symptomatic candidiasis is carried out by local means, without stopping the use of the drug Advair Diskus.
With prolonged use of high doses of Advair Diskus in patients, it is possible to develop systemic effects of fluticasone. In particular, it is impossible to exclude the development of Cushing’s syndrome, Cushingoid signs, growth retardation in children, as well as cataracts, glaucoma and bone mineralization disorders.

Contraindications
Advair Diskus is not prescribed to patients with a history of hypersensitivity reactions to fluticasone, salmeterol or an additional component of the drug.
Advair Diskus is not used for relief of acute symptoms, which require the use of high-speed bronchodilators.
Advair Diskus should be administered with caution to patients suffering from latent and active pulmonary tuberculosis, thyrotoxicosis and diabetes mellitus.

Advair Diskus
Data on the safety of the use of Advair Diskus during breastfeeding and pregnancy are not enough. Presumably, given the low systemic absorption of the active ingredients, when applying therapeutic doses of the drug, Advair Diskus, one should not expect undesired effects on the fetus and the newborn.
During pregnancy and lactation, the appointment of Advair Diskus is possible only by the doctor’s decision after a thorough assessment of the risk-benefit ratio. During pregnancy and lactation, it is recommended that minimal effective doses of Advair Diskus be used for a short period.

Drug Interactions
Advair Diskus should be used with caution combined with beta2-adrenoblockers (simultaneous use of these drugs is allowed only if there are serious indications).
Ritonavir, when combined, increases plasma concentrations and the risk of systemic effects of fluticasone. Simultaneous use of Seretide Diskus with ritonavir is allowed only if the expected benefit exceeds the undesirable systemic effect of corticosteroids.
Caution should be exercised when prescribing Advair Diskus concurrently with erythromycin, ketoconazole and other inhibitors of the cytochrome P450 3A4 system, as these drugs may increase the systemic effect of fluticasone.

Overdose
When using Advair Diskus in doses exceeding recommended, it is possible to develop an overdose of salmeterol or fluticasone.
When overdosage of salmeterol in patients, there is a development of headache, limb tremor and heart rhythm disturbances (in particular, tachycardia).

In acute overdose of fluticasone in patients, a temporary oppression of the hypothalamic-pituitary-adrenal system is possible, which itself passes for several days. With a chronic overdose of fluticasone in patients, it is possible to develop a pronounced suppression of the functions of the adrenal glands. There are data on single cases of development of acute adrenal crisis in chronic overdose of fluticasone. Acute adrenal crisis was noted mainly in children who received high doses of fluticasone for a long time. In this case, patients may develop hypoglycemia with a violation of consciousness and convulsions. It should be borne in mind that to provoke an acute adrenal crisis may be traumas, infectious diseases, surgical interventions and a sharp decrease in the dose of fluticasone.

When developing signs of an overdose of salmeterol, cardioselective beta2-adrenergic blockers are prescribed (it should be taken into account that patients with bronchospasm in the anamnesis are prescribed with beta2-adrenoblockers with caution). If, in connection with an overdose of salmeterol, the withdrawal of Advair Diskus should be prescribed an alternative drug for the treatment of the underlying disease.
To prevent the development of chronic overdose of fluticasone, the patient should be monitored and the dose of Advair Diskus reduced to the minimum effective.

Form of issue
Dosage powder for inhalation Advair Diskus for 60 doses in a blister pack of foil with evenly spaced cells, each of which contains 1 dose. In the cardboard bundle, a plastic device for inhalations with 1 blister pack (60 doses) is inserted.

Storage conditions
The drug Advair Diskus should be stored and transported in the original packaging at a temperature of 15 to 20 degrees Celsius.
The shelf life of the drug Seretid Diskus, if stored, is 1.5 years.

Composition
1 dose of Advair Diskus 50 μg / 100 μg contains:
Salmeterol (in the form of salmeterol xinafoate) – 50 mcg;
Micronized fluticasone propionate – 100 mcg;
Additional Ingredients: lactose.

1 dose of Advair Diskus 50 μg / 250 μg contains:
Salmeterol (in the form of salmeterol xinafoate) – 50 mcg;
Micronized fluticasone propionate 250 μg;
Additional Ingredients: lactose.

1 dose of Advair Diskus 50 μg / 500 μg contains:
Salmeterol (in the form of salmeterol xinafoate) – 50 mcg;
Micronized fluticasone propionate – 500 mcg;
Additional Ingredients: lactose.

Attention!
Description of the drug “Advair Diskus” on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult a doctor and read the annotation approved by the manufacturer.
Information about the drug is provided solely for informational purposes and should not be used as a guide to self-treatment. only the doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

Buy Advair Diskus (Adoair) online.

21.01.2015 | | Asthma

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Prednisone 5MG, 10MG, 20MG, 40MG.

Analog.

Other names for this medication:
Apo-prednisone, Cordrol, Cortancyl, Decortin, Decortisyl, Deltra, Diadreson, Hostacortin, Marsone, Meticorten, Nisone, Norapred, Nosipren, Orasone, Panasol-s, Paracort, Pred-g, Prednibid, Prednicen-m, Prednicot, Predniment, Prednisoloni, Prednisona, Prednisonum, Sterapred, Ultracorten, Winpred.

Prednisone: instruction for receiving, analogues, price, reviews
Prednisone is an anti-inflammatory drug of the group of corticosteroids, which are analogues of the natural biological hormone of the adrenal cortex – cortisol.

Pharmacological interdiction
Glucocorticotropic disease. The drugs, which are used in the case of rheumatoid apteritis, spondylitis, rheumatism of inferior genesis, an apte, a traumatic shock, infectious diseases.

Pharmacological system
Anti-inflammatory, glucocorticoid and anti-inflammatory agent. Stabilizes the state of the cell membranes, inhibits the production of prostaglandins, which are indicative of the appearance of the bulbous syndrome in the case of opol-propellent vehicles.
Reduces the permeability of capillaries, anti-inflammatory agents are reduced by reducing the processing of specific antibodies, the antiprotochic agents are mediated by a cocodifying effect and by the stimulation of the work of the cep-caustic sys- tem. Bystro vsasyvayutsya pepopalnomu ppeeme, maksimmalnye kontsentratsii v krovi dostigayutcya cpustya dva chaca. Tpanfspopiruetcya in the song, deduced by the buds.
It shows effects on lipid, angular and iron metabolism. It will result in cumulation of glycogen glycogen in the liver and an increase in the level of glucose in the blood. The agent helps to keep the water and natrium in the organism, to stimulate the work of the cep-cadic system and to increase the tonus of the ape, to restore the muscle to the contraction. The unique CIC produces a stimulus, acts as a protic and immunodeficient action. It increases the acidity of the gastric juice and the cessation of the vesicle.

Indications for use
In the practice of the treatment of diseases of the opioid motor system and the musculature, it is used in rheumatism, rheumatoid apoptitis, apoptia, celepodermia, and demotomyositis.
It is used in the treatment of allergic diseases, adductor infections, when the functions of the adrenal gland function are absent in the acute form, the anterior spine and hepatitis, the penicle, the hypoglycemia.
It is used in the therapy of lipid infarction, agranulocytosis, leukemia of any etiology, lymphogranematosis, purpura of thrombocytopenic, hemolytic anemia.
B kotteva kompleknoy tepapii in infektsionnomu mononukleeoze, pankkpeatit e ostpoy pom pami, pemphlet, itch neevyatshennoy etiologii, eczema, remmatit, pcopiza, ceptopeinom dammitit, kpacnoy volchanka, eritpodermii. It is used as a prophylactic substance in the case of hock infections.

Transactions
The proprietor of a product in case of a sensitive hypersensitivity to the existing substance or any other component in the body. He does not suffer from ulceration of the duodenum of the rectum and the throat, but only in the small phase. Heppemenim in otteeoopoze, Illinois-Massage, as well as in cases, if the patient cklonen to thromboembolism.

Ppotivopokazano ppimenenie ppepapata VARIATIONS nedoctatochnocti pochechnoy functions tyazheloy fopme aptepialnoy gipeptenzii and gipeptonii, genepalizovannyx zapazheniyax gpibkom (mikoz in tom chicle, kandidoz) DURING vipucnoy infektsii in octpoy or xponicheckoy faze.
It is forbidden to take this drug as a method of vaccination, when active tuberculosis, symptomatic psichicacheki patologiya.

C ostopozhnctyu
It is necessary to observe the condition when the drug is used. Give birth to patients with any form of caspatode, and also for non-specific infectious diseases, in this case, if the staphylococcus is not present, stent.
The condition requires the use of drugs in patients with latent tuberculosis, as well as comfort, the first – the third type.

!!!The use of drugs should be done solely – it is imperative to take an active dose of the doc- tation medication without help!!!

How to accept
The official instruction on the use of drugs Prednisone indicates that dosylvania and the return of the regimen are established individually by the lactating physician in the presence of the severity of the columoric system and the invasive prac- tice.
Suppovyaschie dosizkovki should be appointed after the release of the desired tepepevticheskogo effekta. The pacchet of the supporting force depends on the specified positioning in the active mode – the supporting force must be three times smaller than the one in the active mode.
At the lack of efficiency and in the solution of the lucid dentistry, the initial dosage can be 0.1 g, sup- pressive-0.015 g., While reducing the patient’s concentration of the neopodoma.
A search for the use of a detonator in a hotel paccounts from the body of the body. Paccitannoe a large number of drugs should be allocated for five times.
Single-dose mosaic dosage – not more than 15 mg, cotochnaya – not more than 100 mg. When the outbreak of unhealthy situations, life-threatening conditions, and also when there are shocking things, it is possible to introduce large amounts of equipment under the eye of a doctor.

Side Effects
Lechenie pepperatom can cause such unhealthy effects, such as low resistance to infectious and viral diseases, development of hyperemia, as well as inflammation before the middle child.
Bozmozhnye pobochnye effekty takie, kak nekpozipovanie koctnoy tkani, povyshenie kiclotnocti zheludka and HOW cledctvie, bolevoy cindpom, gipokaliemiya, zadepzhka and water at natpiya in opganizme c otechnoctyu FACE and konechnoctey in pezultate.
It is possible to observe the development of the Ischenka-Cushing syndrome, the increase in the volume of other active objects, the katapakt of the stereotype, which is hidden by the eye, the inapplicability of the cycle of ideas in women.
Co of the system of the central nervous system is also marked by such an irrelevant nature of the reception of the Princess, as if the sleep mode was switched off, the girl in bed, slept in the muscles, the pace of the hand.

When the rotation of the laser is switched off, the Prednisone is possible to develop the Syndrome, which is linked to the reduction of the function of the bag of opacifiers and their assaults.
Avoid the side effects and minimize the likelihood of their manifestations may be hard, pinched individually individual doses.

18.01.2015 | | Bestsellers, Male health, Women's Health

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Analog.

Antibiotic “Amoxil”: instructions for use, testimonials.

Active Ingredient: Amoxicillin.

Other names for this medication:
Acimox, Alfamox, Almodan, Aloxyn, Amix, Amoclen, Amoksicilin, Amopen, Amoram, Amox, Amoxi, Amoxicilina, Amoxicillinum, Amoxiline, Amoxisol, Amoxivet, Amoxypen, Amurol, Apo-amoxi, Bimoxan, Bristamox, Cipmox, Clamoxyl, Flemoxin, Flemoxon, Galenamox, Gimalxina, Hidramox, Hydramox, Larotid, Lupimox, Moxa, Moxicillin, Novamoxin, Nu-amoxi, Ospamox, Penamox, Penimox, Polymox, Raylina, Reloxyl, Rimoxallin, Robamox, Servamox, Sintedix, Solciclina, Stacillin, Sumox, Tolodina, Utimox, Velamox, Wymox, Zimox.

Pharmacology and pharmacokinetics
The main active substance of “Amoxil” is amoxicillin trihydrate. As auxiliary components, calcium stearate, potato starch and low molecular weight medical polyvinylpyrrolidone act. The main component, amoxicillin, is a broad-spectrum antibiotic that is part of the aminopenicillin group.
The substance is characterized by a bactericidal mechanism of action, which is an active suppression of the synthesis of the cell wall of bacteria sensitive to amoxicillin. In the sphere of influence of amoxicillin, there are such well-known gram-positive bacteria as staphylococcus and streptococcus.
The drug is active against a number of gram-negative and anaerobic microorganisms. In tandem with metronidazole, it affects bacteria that promote the development of peptic ulcer in the stomach and duodenum.

Getting inside the body, the antibiotic “Amoxil“, the instruction of which describes in detail all the information about the drug, is actively absorbed and after 2 hours reaches the maximum concentration in the blood serum. Half-life from the body is 1.5 hours. The drug appears through the kidneys almost unchanged (60-70%).

Main Customers
Since “Amoxil” has a wide sphere of influence, the patients taking the drug are people with a variety of diseases. Tablets “Amoxil” instruction recommends that patients suffering from respiratory tract infections: upper (tonsillitis, sinusitis, otitis media) and lower (pneumonia, bronchitis). It is also effective in the treatment of diseases of the bile duct and gastrointestinal tract.

Diseases of the urinary system are also amenable to “Amoxil“. Here we can talk about pyelonephritis, cystitis, asymptomatic bacteriuria in pregnant women. In addition, medical experts prescribe medication in the treatment of acute stages of uncomplicated gonorrhea, infections of the skin and soft tissues.

In addition, its combined (together with other drugs) application is possible and quite effective. “Amoxil” in tandem with clarithromycin or metronidazole is used for therapeutic therapy in diseases of the digestive system, provoked by the bacteria Helicobacter pylori (chronic forms of gastritis, stomach and duodenal ulcers).

Who is not recommended to take “Amoxil”?
Drug medication is contraindicated for people who are hypersensitive to the main active ingredient, auxiliary components, groups of penicillins and cephalosporins. Do not take this medication with mononucleosis and lymphocytic leukemia.
The joint appointment of “Amoxil” with metronidazole is unacceptable for diseases of the nervous system, deviations in the work of the hematopoiesis system. In the same tandem, it is not possible to prescribe a drug to patients younger than 18 years of age suffering from gastrointestinal diseases that are accompanied by prolonged vomiting or diarrhea.

Also, “Amoxil“, the instruction for the application of which describes in detail the contraindications to taking the drug, is forbidden to admit patients suffering from severe pathologies and abnormalities in the functioning of the liver. It is inadmissible to use alcohol during the combined treatment course.

Dosage regimens
Drug medication is manufactured by manufacturers in tablets with a dosage of 250, 500 and 625 mg. “Amoxil” is prescribed inside regardless of food intake. Dosage and treatment regimen is selected by the doctor taking into account the disease and the severity of the patient’s condition. For adults and children over 10 years of age (with a body weight of at least 40 kg), a single dose should be from 250 to 500 mg. In especially severe conditions, up to 1 gram of the drug “Amoxil” is prescribed.

Regardless of the patient’s age, the interval between doses should be at least 8 hours. In people with abnormalities in kidney function, the interval between doses should be increased to 12 hours. For individuals suffering from anuria, the daily norm of “Amoxil” can not exceed 2 grams.

In what cases is the drug “Amoxil-625″ prescribed? The instructions for use, in addition to all the above indications, recommend the use of this drug to suppress dental infections (including the treatment of dentoalveolar abscess), as well as joint and bone infections (including osteomyelitis). Effective medicament in this dosage for septic abortions, postpartum and intra-abdominal sepsis, burns, abscesses and wound infections.

Features of the application of “Amoxil”
In the process of treatment with medication (especially in high doses), experts recommend maintaining adequate diuresis. To avoid the development of crystalluria, it is necessary to take a sufficient amount of liquid.
Long-term use of “Amoxil” or repeated treatment with the same drug after a short period of time can give an impetus to the development of superinfections and to accelerate the growth of a stable microflora. Regardless of the dosage (250 mg or “Amoxil” 500), the instruction manual recommends that children maintain oral hygiene, since the main active ingredient is able to change the color of the tooth enamel.
Patients whose professional activities are associated with performing works that require high concentration of attention, “Amoxil” should be administered with caution, since side effects from the nervous system are possible.

During lactation it is undesirable to take this medicine, as it is excreted in breast milk, which can lead to sensitization of the baby (increased sensitivity to the active ingredient, the possibility of allergic reactions).

Any dosage of the drug, even Amoxil 250, is not recommended for women taking estrogen-containing contraceptives, since amoxicillin reduces their effectiveness. Slowed down the process of removing the drug through the kidneys, if in conjunction with “Amoxil” the patient takes indomethacin, acetylsallicyl acid (aspirin), sulfinpyrazone, oxyphenbutazone, phenylbutazone.

Exceeding the permissible dose
Symptoms of excess of a single dosage of medication are: nausea, vomiting, diarrhea, deviation from the norm of water electrolyte balance. To eliminate the consequences, gastric lavage is performed, the use of absorbent drugs (in particular activated charcoal), saline laxatives is prescribed, measures are taken to correct the water-electrolyte balance. In especially severe cases, a hemodialysis procedure may be required (purification of blood outside the kidneys).

Possible side effects
What side effects does the antibiotic “Amoxil” have? Instructions for use describe possible problems from various body systems.
The gastrointestinal tract can respond to the reception of “Amoxil” with nausea, vomiting, diarrhea. In more severe cases, it is possible to develop hemorrhagic or pseudomembranous colitis, candidiasis of the intestine. From the side of the urinary system, interstitial nephritis is often observed. Manifestations of the same disease can be expected from the hemopoietic system. Also sometimes thrombocytopenia, leukopenia, hemolytic anemia, crystalluria develops. A negative reaction to “Amoxil” from the side of the nervous system can be expressed in the appearance of convulsions, dizziness and the state of hyperactivity.
Sometimes there are all kinds of allergic reactions (rash, itching, hives, conjunctivitis, allergic vasculitis, angioedema).

What else is dangerous, “Amoxil”? Instruction, patient reviews and numerous studies confirm that the action of the drug can trigger the development of anaphylaxis, multiforme erythema, candidiasis of the mucous membranes and skin, cholestatic jaundice, hepatitis, Stevens-Johnson syndrome (malignant erythema).

“Amoxil” and angina
Angina in the people is called the infectious process, which manifests itself in the inflammation of the components of the lymphatic pharyngeal ring. Most often, tonsils are involved in the process. Inflammation is caused by streptococci or staphylococci. In most cases, to combat this bacterial disease, medical professionals prefer to use antibiotics penicillin group. One of these drugs is “Amoxil“.
Tablets instructions for use recommend appointing regardless of food intake. In this case, they should be swallowed whole and washed down with water. Usually the drug is taken at intervals of not less than 8 hours. However, the treatment regimen and dosage can be selected individually by the attending physician depending on the severity of the patient’s condition.
Pediatricians usually receive pediatricians for treatment of “Amoxil” 250. The instruction describes dosage regimens depending on the age and weight of the child. Babies under 2 years are usually prescribed a daily rate equal to 30 mg of the drug per kilogram of weight. The total dose should be divided into 3 doses. Children of the age group from 2 to 5 years once a day prescribed 125 mg of medicament.
Starting from the age of 5 and up to 10 years, a single daily intake is 250 mg. From 12 years old, one tablet (625 mg) is prescribed for adolescents from the age of 12 for the treatment of angina. The interval between doses is 12 hours.

To treat bacterial sore throat in adult patients, therapists prescribe “Amoxil” 500. The instructions for use describe the treatment regimen in the form of a single dose of 500 mg. In the case of a severe process, the doctor may prescribe a single dose of the drug to 1 gram. The maximum daily dose for angina should not exceed 6 grams. “Amoxil” at a dosage of 625 mg is often prescribed in the treatment of tonsillitis.
Tablets are taken once with an interval of 12 hours. If a patient suffers chronic renal failure, he is prescribed a dose of 625 mg once a day for angina. Patients on hemodialysis after taking the procedure additionally take 1 tablet of the drug.

!!!In any case, the scheme of therapy with the drug “Amoxil” with angina should be selected by the treating doctor.!!!

Interaction of “Amoxil” with other drugs
As mentioned earlier, the use of Amkosil by women using oral contraceptives is undesirable, since the effectiveness of the latter is reduced. In addition, the development of bleeding is possible. If the patient suffers from cardiovascular diseases (in particular, arrhythmia) and takes digoxin, simultaneous reception of “Amoxil” will strengthen it (digoxin) absorption.
With the simultaneous administration of drugs that have a bacteriostatic effect (macrolides, tetracyclines, chloramphenicol) and “Amoxil” medication, the instructions for use inform the patients that the bactericidal action of amoxicillin, the main active ingredient in Amoxil, will be neutralized. If, for any reason, there was a need for an intensive diuresis (abundant drinking and simultaneous use of diuretics), the concentration of medication in the body will be lowered.
With the simultaneous administration of “Amoxil” and “Allopurinol” (prescribed for patients with elevated levels of uric acid in the blood), the frequency of allergic reactions from the skin can increase. Unsuitable joint administration of antacids (medications intended for the treatment of acid-dependent gastrointestinal diseases by neutralizing the hydrochloric acid of gastric juice) and the drug “Amoxil” (tablets) is not desirable.
Instruction for use informs that in this case the absorption of amoxicillin will be reduced. Carefully appointed a complex method of “Amoxil” and anticoagulants (substances and medications that depress the blood clotting system and prevent thrombosis). In this case, continuous monitoring of prothrombin time is necessary, since the probability of bleeding is quite high. Manifestations from the digestive system in the form of diarrhea reduce the absorption of drugs, as a result of which the action of “Amoxil” worsens.
The use of this antibiotic can reduce the content of estradiol (the most active female sex hormone – estrogen) in the urine of pregnant women.

In any case, no matter how simple the patient might feel his illness, self-medication is an unacceptably frivolous attitude to one’s own health. A drug that successfully cured a sore throat to a colleague at work can cause a lot of side effects in another patient, starting with a rash on the skin and ending with irreversible lesions of certain organs and systems that can cost you not only health but also life.
The modern pharmaceutical market is so complex and diverse that only a highly qualified medical specialist is able to understand all these scientific terms, doses and schemes, and to develop a course of treatment therapy individually for each individual patient, taking into account his state of health, while minimizing the risk of side effects .

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18.01.2015 | | Antibiotics, Male health, Women's Health

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Analog.

Clinical and pharmacological group
Antibiotic of the tetracycline group.

Pharmachologic effect
Semisynthetic tetracycline, bacteriostatic broad-spectrum antibiotic. Penetrating into the cell, acts on intracellularly located pathogens. Suppresses the synthesis of proteins in a microbial cell, disrupts the binding of the transport aminoacyl RNA to the 30S subunit of the ribosomal membrane.
Gram-positive microorganisms are highly sensitive to it: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus pneumoniae), Clostridium spp., Listeria spp .; Actinomyces israeli; and Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Klebsiella spp., Escherichia coli, Shigella spp., Enterobacter, Salmonella spp., Bordetella pertussis. Bacteroides spp., Treponema spp. (including strains resistant to other antibiotics, such as modern penicillins and cephalosporins). The most sensitive are Haemophilus influenzae (91-96%) and intracellular pathogens.
Doxycycline is active against most pathogens of dangerous infectious diseases: plague (Yersinia spp.), Tularemia (Francisella tularensis), anthrax (Bacillus anthracis), legionella (Legionella spp.), Brucella (Brucella spp.), Cholera vibrio (Vibrio cholera) , Rickettsia (Rickettsia spp.), glanders pathogens (Actinobacillus mallei), Chlamydia (psittacosis pathogens (Chlamydia psittaci), psittacosis (Rickettsiaformis psittacosi), trachoma (Chlamydia trachomatis ;, venereal granuloma (Calymmatobacterium granulomatis), malaria (Plasmodium falciparum), amoebic dysentery (Entamoeba histolytica).

It acts on most proteic strains, Pseudomonas aeruginosa and fungi.
To a lesser extent than other antibiotics of the tetracycline, it oppresses the intestinal flora, differs from them by a more complete absorption and longer duration of action. By the degree of antibacterial activity, doxycycline is superior to natural tetracyclines. In contrast to tetracycline and oxytetracycline, it has higher therapeutic efficacy, which is manifested by treatment in 10 times smaller doses, and a longer action. There is cross-resistance to other tetracyclines, as well as to penicillins.

Pharmacokinetics
Absorption is fast and high (about 100%). The intake of food has no significant effect on the degree of absorption. Has a high degree of solubility in lipids and a low affinity for the binding of calcium ions (Ca2 +). After oral administration of 200 mg the time to reach the maximum concentration in blood plasma is 2.5 hours, the maximum concentration in the blood plasma is 2.5 μg / ml, after 24 hours after the intake – 1.25 μg / ml.
The connection with plasma proteins is 80-93%. It penetrates well into organs and tissues; 30-45 minutes after ingestion is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissues, pleural and ascitic fluids, bile, synovial exudate, exudate of maxillary sinuses and frontal sinuses, in fluid gingival sulci. Poor penetration into the cerebrospinal fluid (10-20% of the plasma level). Penetrates through the placental barrier, is determined in human milk. The volume of distribution is 0.7 l / kg.
Metabolised in the liver 30-60%. The half-life is 10-16 hours (basically 12-14 hours, on the average – 16.3 hours). With repeated administration, the drug can accumulate. It accumulates in the reticulo-endothelial system and bone tissue. In bones and teeth, it forms insoluble complexes with calcium ions (Ca2 +). It is excreted with bile, where it is found in high concentration. It is subjected to intestinal-hepatic recirculation, is excreted by the intestine (20-60%); 40% of the dose is given by the kidneys for 72 hours (of which 20-50% is unchanged), in severe chronic renal failure, only 1-5%.
In patients❛ with impaired renal function or azotemia, gastrointestinal secretion is an important way of excretion.

Indications❛
⊳Infectious-inflammatory❛ diseases caused by sensitive microorganisms: respiratory tract infections (pharyngitis, acute and chronic bronchitis, tracheitis, bronchopneumonia, lobar pneumonia, lung abscess, pleural empyema);

⊳infections❛ of the ENT organs (otitis media, tonsillitis, sinusitis, etc.);

⊳infections❛ of the genitourinary system (cystitis, pyelonephritis, prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, endometritis, endocervicitis, acute orchypididitis, gonorrhea);

⊳infections❛ of the biliary tract and gastrointestinal tract (cholecystitis, cholangitis, gastroenterocolitis, bacterial dysentery, traveler’s diarrhea);

⊳infections❛ of the skin and soft tissues (phlegmon, abscess, furunculosis, panaritium, infected burns, wounds, etc.);

⊳infectious❛ diseases of the eyes, syphilis, yawsinosis, legionellosis, rickettsiosis, chlamydia of various localizations (including prostatitis and proctitis), fever Koo, spotted fever of❛ the Rocky❛ Mountains, typhus (including mucous, tick-borne, recurrent) , Lyme disease (I v. – erythema migrans), bacillary and amoebic dysentery, tularemia, cholera, actinomycosis, malaria;

⊳in the combination❛ therapy – leptospirosis, trachoma, psittacosis, ornithosis, granulocyte erlichiosis;

⊳whooping❛ cough, brucellosis, osteomyelitis;

⊳sepsis, subacute septic❛ endocarditis, peritonitis;

⊳prevention of❛ postoperative purulent complications;

⊳malaria caused by Plasmodium❛ falciparum, during short trips (less than 4 months) in a territory where strains resistant to❛ chloroquine and / or pyrimethamine sulfadoxine are common;

As a preparation of the “first” series, patients under 65 years of age are exacerbated with exacerbation of chronic bronchitis (including bronchial asthma) without concomitant diseases (these exacerbations are often caused by Haemophilus influenzae). Effective with exacerbation of bronchopulmonary infection (usually staphylococcal etiology) in patients with cystic fibrosis, chlamydial arthritis, granulocyte erlichiosis. In elderly patients it is used to treat acute prostatitis and urinary infection caused by Escherichia coli.

Contraindications
⇨hypersensitivity to doxycycline, drug components, other tetracyclines;
⇨deficiency of lactase;
⇨Lactose intolerance;
⇨glucose-galactose malabsorption;
⇨porphyria;
⇨Severe hepatic impairment;
⇨Lakopenia;
⇨Children’s age (up to 12 years – the possibility of formation of insoluble complexes with calcium ions (Ca2 +) with deposition in the bone skeleton, enamel and dentin teeth);
⇨Children aged after 12 years with a body weight of up to 45 kg.

Dosage
Inside, in adults and children over 12 years with a body weight of more than 45 kg, the average daily dose is 200 mg on the first day (divided into 2 divided doses – 100 mg twice a day), then 100 mg / day.
In chronic infections of the urinary system – 200 mg / day throughout the period of therapy.
In the treatment of gonorrhea, one of the following regimens is prescribed: acute uncomplicated urethritis – a course dose of 500 mg (1 reception – 300 mg, subsequent 2 – 100 mg at 6-hour intervals) or 100 mg / day until complete cure (in women) or 100 mg 2 times a day for 7 days (in men); with complicated forms of gonorrhea, the course dose is 800-900 mg, which is divided into 6-7 receptions (300 mg – 1 reception, then at an interval of 6 hours for 5-6 follow-up).
In the treatment of syphilis – 300 mg / day for at least 10 days.
In uncomplicated infections of the urethra, cervix and rectum caused by Chlamydia trachomatis, 100 mg are prescribed twice a day for at least 7 days.
Infections of male genital organs – 100 mg twice a day for 4 weeks. Treatment of malaria resistant to chloroquine – 200 mg / day for 7 days (in combination with shizontocidal drugs – quinine); malaria prophylaxis -100 mg once a day 1-2 days before the trip, then daily during the trip and for 4 weeks after return;
Diarrhea “travelers” (prevention) – 200 mg on the first day of the trip (for 1 dose or 100 mg twice a day), 100 mg once a day during the entire stay in the region (no more than 3 weeks).
Treatment of leptospirosis – 100 mg orally 2 times a day for 7 days; prophylaxis of leptospirosis – 200 mg once a week during a stay in a dysfunctional area and 200 mg at the end of the trip.
Prevention of infections after medical abortion – 100 mg for 1 hour before abortion and 200 mg – 30 minutes after.
With acne – 100 mg / day, the course – 6-12 weeks.
Maximum daily doses for adults – up to 300 mg / day or 600 mg / day for 5 days with severe gonococcal infections.
In the presence of severe hepatic insufficiency, a decrease in the daily dose of doxycycline is required, since in this case a gradual accumulation of it in the body takes place (the risk of hepatotoxic action).

Side effects
❂From the side of the nervous system: a benign increase in intracranial pressure (decreased appetite, vomiting, headache, edema of the optic nerve disc), toxic effects on the central nervous system (dizziness or instability),
❂Metabolic disorders: anorexia.
From the organs of hearing and the vestibular apparatus: ringing in the ears.
❂From the side of vision: blurred vision, scotoma and diplopia as a result of increased intracranial pressure.
❂From the digestive system: nausea, constipation or diarrhea, abdominal pain, glossitis, dysphagia, esophagitis (including erosive), gastritis, ulceration of the stomach and duodenum, pseudomembranous colitis, enterocolitis (due to the proliferation of resistant Staphylococcus strains ).
❂Allergic reactions: maculopapular rash, skin itching, skin hyperemia, angioedema, anaphylactoid reactions, drug lupus erythematosus, erythematous rash, exfoliative dermatitis, urticaria, anaphylaxis, anaphylactic shock, anaphylactoid reactions, Stevens-Johnson syndrome.
❂From the cardiovascular system: pericarditis, lowering blood pressure, tachycardia, erythema multiforme.
❂From the hemopoiesis: hemolytic anemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, a decrease in the prothrombin index.
❂On the part of the hepatobiliary system: a violation of the liver, increased levels of hepatic transaminases, autoimmune hepatitis, cholestasis.
❂Musculoskeletal: arthralgia, myalgia.
❂Impaired renal and urinary tract function: Increased level of residual urea nitrogen.
❂Other: photosensitization, superinfection; stable change in the color of tooth enamel, inflammation in the anogenital zone. Candidiasis (vaginitis, glossitis, stomatitis, proctitis), dysbacteriosis, a syndrome similar to serum sickness, toxic epidermal necrolysis.

Overdose
❃Symptoms: with the introduction of high doses, especially in patients with impaired liver function, neurotoxic ❃Reactions may appear: dizziness, nausea, vomiting, convulsions, impaired consciousness due to increased intracranial pressure.
❃Treatment: drug withdrawal, gastric lavage with activated charcoal, symptomatic therapy, inside appoint antacids and magnesium sulfate to prevent the absorption of doxycycline. There is no specific antidote. Hemodialysis and peritoneal dialysis are ineffective.

Drug Interactions
Absorption is reduced by antacids containing salts of aluminum (Al3 +), calcium (Ca2 +) and magnesium (Mg2 +), iron preparations (Fe), sodium hydrogen carbonate, laxatives containing magnesium salts (Mg2 +), colestyramine and colestipol, therefore their use should be divided an interval of 3 hours.
In connection with the suppression of the intestinal microflora reduces the prothrombin index, which requires correction of the dose of indirect anticoagulants.
When combined with bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins), the effectiveness of the latter is reduced. Reduces the reliability of contraception and increases the frequency of bleeding “breakthrough” against the background of taking estrogen-containing oral contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the plasma.
With simultaneous use with methoxyflurane, it is possible to develop acute renal failure, up to a lethal outcome.
Simultaneous use of retinol helps increase intracranial pressure.

Special instructions
To prevent locally irritating effect (esophagitis, gastritis, ulceration of the mucous membrane of the gastrointestinal tract) it is recommended to take in the daytime hours with a lot of liquid, food. In connection with the possible development of photosensitization, it is necessary to limit the insolation during treatment and for 4-5 days after it. With prolonged use, periodic monitoring of liver function, hematopoiesis is necessary. May mask the manifestations of syphilis, in connection with which, with the possibility of a mixed infection, a monthly serological analysis is necessary for 4 months. All tetracyclines form stable complexes with calcium ions (Ca2 +) in any bone-forming tissue. In this regard, reception during the development of teeth can cause long-term staining of teeth in yellow-gray-brown color, as well as hypoplasia of the enamel. Perhaps a false increase in the level of catecholamines in urine when determined by the fluorescent method. In the study of the thyroid biopsy in patients who have been receiving doxycycline for a long time, it is possible to dark brown staining of the tissue in micropreparations without disturbing its function.
In the experiment, it has been established that doxycycline can exert a toxic effect on the development of the fetus (delay in the development of the skeleton) – blocks metalloproteases (enzymes that catalyze the degradation of collagen and proteoglycans) in the cartilage, leading to a reduction in lesions in deforming osteoarthritis. When the dose is increased above 4 g, the pharmacokinetics of doxycycline does not depend on the dose and the concentration in the blood does not increase.
When using the drug, both on the background of taking and 2-3 weeks after stopping treatment, it is possible to develop diarrhea caused by Clostridium difficile. In light cases, it is sufficient to cancel treatment and use ion-exchange resins (colestyramine, colestipol), in severe cases, compensation for loss of fluid, electrolytes and protein, the appointment of vancomycin, bacitracin or metronidazole. Do not use drugs that inhibit the intestinal motility.
Impact on the ability to drive vehicles and manage mechanisms
Patients should refrain from all activities requiring increased attention, rapid mental and motor.

Pregnancy and lactemia
The use of the drug during pregnancy is contraindicated, because, penetrating the placenta, the drug can disrupt the normal development of the teeth, inhibit the growth of the bones of the fetal skeleton, and also cause fatty liver infiltration.
During the lactation period, the use of doxycycline is contraindicated. In case of need of application of a preparation, for the period of treatment feeding by a breast should be stopped.

Application in childhood
Contraindicated for children under 12 years of age (the possibility of formation of insoluble complexes with calcium ions (Ca2 +) with deposition in the bone skeleton, enamel and dentin of the teeth); and children aged after 12 years with a body weight of up to 45 kg.
Application is possible in children older than 12 years with a body weight of more than 45 kg according to the dosing regimen.

With violations of liver function
Contraindicated in severe hepatic insufficiency. In the presence of severe hepatic insufficiency, a decrease in the daily dose of doxycycline is required, since in this case a gradual accumulation of it in the body takes place (the risk of hepatotoxic action).

Terms and conditions of storage
In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life – 4 years.

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18.01.2015 | | Bestsellers, Male health, Women's Health

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