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Analog.

Clinical and pharmacological group
Antibiotic of the tetracycline group.

Pharmachologic effect
Semisynthetic tetracycline, bacteriostatic broad-spectrum antibiotic. Penetrating into the cell, acts on intracellularly located pathogens. Suppresses the synthesis of proteins in a microbial cell, disrupts the binding of the transport aminoacyl RNA to the 30S subunit of the ribosomal membrane.
Gram-positive microorganisms are highly sensitive to it: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus pneumoniae), Clostridium spp., Listeria spp .; Actinomyces israeli; and Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Klebsiella spp., Escherichia coli, Shigella spp., Enterobacter, Salmonella spp., Bordetella pertussis. Bacteroides spp., Treponema spp. (including strains resistant to other antibiotics, such as modern penicillins and cephalosporins). The most sensitive are Haemophilus influenzae (91-96%) and intracellular pathogens.
Doxycycline is active against most pathogens of dangerous infectious diseases: plague (Yersinia spp.), Tularemia (Francisella tularensis), anthrax (Bacillus anthracis), legionella (Legionella spp.), Brucella (Brucella spp.), Cholera vibrio (Vibrio cholera) , Rickettsia (Rickettsia spp.), glanders pathogens (Actinobacillus mallei), Chlamydia (psittacosis pathogens (Chlamydia psittaci), psittacosis (Rickettsiaformis psittacosi), trachoma (Chlamydia trachomatis ;, venereal granuloma (Calymmatobacterium granulomatis), malaria (Plasmodium falciparum), amoebic dysentery (Entamoeba histolytica).

It acts on most proteic strains, Pseudomonas aeruginosa and fungi.
To a lesser extent than other antibiotics of the tetracycline, it oppresses the intestinal flora, differs from them by a more complete absorption and longer duration of action. By the degree of antibacterial activity, doxycycline is superior to natural tetracyclines. In contrast to tetracycline and oxytetracycline, it has higher therapeutic efficacy, which is manifested by treatment in 10 times smaller doses, and a longer action. There is cross-resistance to other tetracyclines, as well as to penicillins.

Pharmacokinetics
Absorption is fast and high (about 100%). The intake of food has no significant effect on the degree of absorption. Has a high degree of solubility in lipids and a low affinity for the binding of calcium ions (Ca2 +). After oral administration of 200 mg the time to reach the maximum concentration in blood plasma is 2.5 hours, the maximum concentration in the blood plasma is 2.5 μg / ml, after 24 hours after the intake – 1.25 μg / ml.
The connection with plasma proteins is 80-93%. It penetrates well into organs and tissues; 30-45 minutes after ingestion is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissues, pleural and ascitic fluids, bile, synovial exudate, exudate of maxillary sinuses and frontal sinuses, in fluid gingival sulci. Poor penetration into the cerebrospinal fluid (10-20% of the plasma level). Penetrates through the placental barrier, is determined in human milk. The volume of distribution is 0.7 l / kg.
Metabolised in the liver 30-60%. The half-life is 10-16 hours (basically 12-14 hours, on the average – 16.3 hours). With repeated administration, the drug can accumulate. It accumulates in the reticulo-endothelial system and bone tissue. In bones and teeth, it forms insoluble complexes with calcium ions (Ca2 +). It is excreted with bile, where it is found in high concentration. It is subjected to intestinal-hepatic recirculation, is excreted by the intestine (20-60%); 40% of the dose is given by the kidneys for 72 hours (of which 20-50% is unchanged), in severe chronic renal failure, only 1-5%.
In patients❛ with impaired renal function or azotemia, gastrointestinal secretion is an important way of excretion.

Indications❛
⊳Infectious-inflammatory❛ diseases caused by sensitive microorganisms: respiratory tract infections (pharyngitis, acute and chronic bronchitis, tracheitis, bronchopneumonia, lobar pneumonia, lung abscess, pleural empyema);

⊳infections❛ of the ENT organs (otitis media, tonsillitis, sinusitis, etc.);

⊳infections❛ of the genitourinary system (cystitis, pyelonephritis, prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, endometritis, endocervicitis, acute orchypididitis, gonorrhea);

⊳infections❛ of the biliary tract and gastrointestinal tract (cholecystitis, cholangitis, gastroenterocolitis, bacterial dysentery, traveler’s diarrhea);

⊳infections❛ of the skin and soft tissues (phlegmon, abscess, furunculosis, panaritium, infected burns, wounds, etc.);

⊳infectious❛ diseases of the eyes, syphilis, yawsinosis, legionellosis, rickettsiosis, chlamydia of various localizations (including prostatitis and proctitis), fever Koo, spotted fever of❛ the Rocky❛ Mountains, typhus (including mucous, tick-borne, recurrent) , Lyme disease (I v. – erythema migrans), bacillary and amoebic dysentery, tularemia, cholera, actinomycosis, malaria;

⊳in the combination❛ therapy – leptospirosis, trachoma, psittacosis, ornithosis, granulocyte erlichiosis;

⊳whooping❛ cough, brucellosis, osteomyelitis;

⊳sepsis, subacute septic❛ endocarditis, peritonitis;

⊳prevention of❛ postoperative purulent complications;

⊳malaria caused by Plasmodium❛ falciparum, during short trips (less than 4 months) in a territory where strains resistant to❛ chloroquine and / or pyrimethamine sulfadoxine are common;

As a preparation of the “first” series, patients under 65 years of age are exacerbated with exacerbation of chronic bronchitis (including bronchial asthma) without concomitant diseases (these exacerbations are often caused by Haemophilus influenzae). Effective with exacerbation of bronchopulmonary infection (usually staphylococcal etiology) in patients with cystic fibrosis, chlamydial arthritis, granulocyte erlichiosis. In elderly patients it is used to treat acute prostatitis and urinary infection caused by Escherichia coli.

Contraindications
⇨hypersensitivity to doxycycline, drug components, other tetracyclines;
⇨deficiency of lactase;
⇨Lactose intolerance;
⇨glucose-galactose malabsorption;
⇨porphyria;
⇨Severe hepatic impairment;
⇨Lakopenia;
⇨Children’s age (up to 12 years – the possibility of formation of insoluble complexes with calcium ions (Ca2 +) with deposition in the bone skeleton, enamel and dentin teeth);
⇨Children aged after 12 years with a body weight of up to 45 kg.

Dosage
Inside, in adults and children over 12 years with a body weight of more than 45 kg, the average daily dose is 200 mg on the first day (divided into 2 divided doses – 100 mg twice a day), then 100 mg / day.
In chronic infections of the urinary system – 200 mg / day throughout the period of therapy.
In the treatment of gonorrhea, one of the following regimens is prescribed: acute uncomplicated urethritis – a course dose of 500 mg (1 reception – 300 mg, subsequent 2 – 100 mg at 6-hour intervals) or 100 mg / day until complete cure (in women) or 100 mg 2 times a day for 7 days (in men); with complicated forms of gonorrhea, the course dose is 800-900 mg, which is divided into 6-7 receptions (300 mg – 1 reception, then at an interval of 6 hours for 5-6 follow-up).
In the treatment of syphilis – 300 mg / day for at least 10 days.
In uncomplicated infections of the urethra, cervix and rectum caused by Chlamydia trachomatis, 100 mg are prescribed twice a day for at least 7 days.
Infections of male genital organs – 100 mg twice a day for 4 weeks. Treatment of malaria resistant to chloroquine – 200 mg / day for 7 days (in combination with shizontocidal drugs – quinine); malaria prophylaxis -100 mg once a day 1-2 days before the trip, then daily during the trip and for 4 weeks after return;
Diarrhea “travelers” (prevention) – 200 mg on the first day of the trip (for 1 dose or 100 mg twice a day), 100 mg once a day during the entire stay in the region (no more than 3 weeks).
Treatment of leptospirosis – 100 mg orally 2 times a day for 7 days; prophylaxis of leptospirosis – 200 mg once a week during a stay in a dysfunctional area and 200 mg at the end of the trip.
Prevention of infections after medical abortion – 100 mg for 1 hour before abortion and 200 mg – 30 minutes after.
With acne – 100 mg / day, the course – 6-12 weeks.
Maximum daily doses for adults – up to 300 mg / day or 600 mg / day for 5 days with severe gonococcal infections.
In the presence of severe hepatic insufficiency, a decrease in the daily dose of doxycycline is required, since in this case a gradual accumulation of it in the body takes place (the risk of hepatotoxic action).

Side effects
❂From the side of the nervous system: a benign increase in intracranial pressure (decreased appetite, vomiting, headache, edema of the optic nerve disc), toxic effects on the central nervous system (dizziness or instability),
❂Metabolic disorders: anorexia.
From the organs of hearing and the vestibular apparatus: ringing in the ears.
❂From the side of vision: blurred vision, scotoma and diplopia as a result of increased intracranial pressure.
❂From the digestive system: nausea, constipation or diarrhea, abdominal pain, glossitis, dysphagia, esophagitis (including erosive), gastritis, ulceration of the stomach and duodenum, pseudomembranous colitis, enterocolitis (due to the proliferation of resistant Staphylococcus strains ).
❂Allergic reactions: maculopapular rash, skin itching, skin hyperemia, angioedema, anaphylactoid reactions, drug lupus erythematosus, erythematous rash, exfoliative dermatitis, urticaria, anaphylaxis, anaphylactic shock, anaphylactoid reactions, Stevens-Johnson syndrome.
❂From the cardiovascular system: pericarditis, lowering blood pressure, tachycardia, erythema multiforme.
❂From the hemopoiesis: hemolytic anemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, a decrease in the prothrombin index.
❂On the part of the hepatobiliary system: a violation of the liver, increased levels of hepatic transaminases, autoimmune hepatitis, cholestasis.
❂Musculoskeletal: arthralgia, myalgia.
❂Impaired renal and urinary tract function: Increased level of residual urea nitrogen.
❂Other: photosensitization, superinfection; stable change in the color of tooth enamel, inflammation in the anogenital zone. Candidiasis (vaginitis, glossitis, stomatitis, proctitis), dysbacteriosis, a syndrome similar to serum sickness, toxic epidermal necrolysis.

Overdose
❃Symptoms: with the introduction of high doses, especially in patients with impaired liver function, neurotoxic ❃Reactions may appear: dizziness, nausea, vomiting, convulsions, impaired consciousness due to increased intracranial pressure.
❃Treatment: drug withdrawal, gastric lavage with activated charcoal, symptomatic therapy, inside appoint antacids and magnesium sulfate to prevent the absorption of doxycycline. There is no specific antidote. Hemodialysis and peritoneal dialysis are ineffective.

Drug Interactions
Absorption is reduced by antacids containing salts of aluminum (Al3 +), calcium (Ca2 +) and magnesium (Mg2 +), iron preparations (Fe), sodium hydrogen carbonate, laxatives containing magnesium salts (Mg2 +), colestyramine and colestipol, therefore their use should be divided an interval of 3 hours.
In connection with the suppression of the intestinal microflora reduces the prothrombin index, which requires correction of the dose of indirect anticoagulants.
When combined with bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins), the effectiveness of the latter is reduced. Reduces the reliability of contraception and increases the frequency of bleeding “breakthrough” against the background of taking estrogen-containing oral contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the plasma.
With simultaneous use with methoxyflurane, it is possible to develop acute renal failure, up to a lethal outcome.
Simultaneous use of retinol helps increase intracranial pressure.

Special instructions
To prevent locally irritating effect (esophagitis, gastritis, ulceration of the mucous membrane of the gastrointestinal tract) it is recommended to take in the daytime hours with a lot of liquid, food. In connection with the possible development of photosensitization, it is necessary to limit the insolation during treatment and for 4-5 days after it. With prolonged use, periodic monitoring of liver function, hematopoiesis is necessary. May mask the manifestations of syphilis, in connection with which, with the possibility of a mixed infection, a monthly serological analysis is necessary for 4 months. All tetracyclines form stable complexes with calcium ions (Ca2 +) in any bone-forming tissue. In this regard, reception during the development of teeth can cause long-term staining of teeth in yellow-gray-brown color, as well as hypoplasia of the enamel. Perhaps a false increase in the level of catecholamines in urine when determined by the fluorescent method. In the study of the thyroid biopsy in patients who have been receiving doxycycline for a long time, it is possible to dark brown staining of the tissue in micropreparations without disturbing its function.
In the experiment, it has been established that doxycycline can exert a toxic effect on the development of the fetus (delay in the development of the skeleton) – blocks metalloproteases (enzymes that catalyze the degradation of collagen and proteoglycans) in the cartilage, leading to a reduction in lesions in deforming osteoarthritis. When the dose is increased above 4 g, the pharmacokinetics of doxycycline does not depend on the dose and the concentration in the blood does not increase.
When using the drug, both on the background of taking and 2-3 weeks after stopping treatment, it is possible to develop diarrhea caused by Clostridium difficile. In light cases, it is sufficient to cancel treatment and use ion-exchange resins (colestyramine, colestipol), in severe cases, compensation for loss of fluid, electrolytes and protein, the appointment of vancomycin, bacitracin or metronidazole. Do not use drugs that inhibit the intestinal motility.
Impact on the ability to drive vehicles and manage mechanisms
Patients should refrain from all activities requiring increased attention, rapid mental and motor.

Pregnancy and lactemia
The use of the drug during pregnancy is contraindicated, because, penetrating the placenta, the drug can disrupt the normal development of the teeth, inhibit the growth of the bones of the fetal skeleton, and also cause fatty liver infiltration.
During the lactation period, the use of doxycycline is contraindicated. In case of need of application of a preparation, for the period of treatment feeding by a breast should be stopped.

Application in childhood
Contraindicated for children under 12 years of age (the possibility of formation of insoluble complexes with calcium ions (Ca2 +) with deposition in the bone skeleton, enamel and dentin of the teeth); and children aged after 12 years with a body weight of up to 45 kg.
Application is possible in children older than 12 years with a body weight of more than 45 kg according to the dosing regimen.

With violations of liver function
Contraindicated in severe hepatic insufficiency. In the presence of severe hepatic insufficiency, a decrease in the daily dose of doxycycline is required, since in this case a gradual accumulation of it in the body takes place (the risk of hepatotoxic action).

Terms and conditions of storage
In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life – 4 years.

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Analog.

Active Ingredient: Propranolol.

Other names for this medication:
N-propranolol.

Pharmacological action of the drug
Hypotensive, antianginal, antiarrhythmic, uterotonizing.
Blocks beta1 and beta2-adrenergic receptors, has a membrane-stabilizing effect. It reduces the heart rate, reduces the force of the heart and the need for myocardium in oxygen. Reduces cardiac output, renin secretion, arterial pressure, renal blood flow and glomerular filtration rate. After taking a single dose, the hypotensive effect lasts for 20-24 hours. With prolonged use reduces venous return, has a cardioprotective effect.
In patients with moderate form of hypertension – reduces the likelihood of developing IHD and cerebral strokes. With IHD reduces the frequency of seizures, increases the tolerance of physical exertion, reduces the need for nitroglycerin. It is most effective in patients of young age (under 40 years) with hyperdynamic type of circulation and with increased content of renin.
Increases the tone of the bronchi and contractility of the uterus (reduces bleeding during labor and in the postoperative period), increases secretory and motor activity of the gastrointestinal tract. It inhibits platelet aggregation and activates fibrinolysis. Inhibits lipolysis in adipose tissue, preventing the increase in the level of free fatty acids (the concentration of triglycerides in the plasma and the coefficient of atherogenity increase.)
Suppresses glycogenolysis, secretion of glucagon and insulin, the conversion of thyroxine to triiodothyronine .It reduces intraocular pressure, reduces the secretion of watery moisture. and almost completely absorbed from the digestive tract.It is almost completely associated with plasma proteins.Conducts in lung tissue, brain, kidneys, heart, passes through the parade succinic barrier, enters the breast milk. Excreted kidneys as metabolites.

Indications for prescription
Arterial hypertension, angina pectoris, sinus tachycardia (including hyperthyroidism), supraventricular tachycardia, tachysystolic atrial fibrillation, supraventricular and ventricular extrasystole, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, sympathoadrenal crisis in patients with diencephalic syndrome, neurocirculatory dystonia, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prophylaxis), ancillary treatment and pheochromocytoma (only in association with alpha-blockers), thyrotoxicosis (including preoperative) thyrotoxic crisis, primary uterine inertia, menopausal vasomotor symptoms of withdrawal syndrome; treatment of akathisia caused by neuroleptics.

Contraindications
Hypersensitivity, AV blockade of II-III degree, sinoatrial block, bradycardia (less than 55 bpm), sinus node weakness syndrome, arterial hypotension, acute and severe chronic heart failure, Prinzmetal angina, cardiogenic shock, obliterating vascular diseases, bronchial asthma.
For the duration of treatment, breastfeeding should be discontinued.

➡Restrictions on the use:
☞Chronic bronchitis,
☞emphysema,
☞diabetes mellitus,
☞hypoglycemia,
☞acidosis,
☞impaired liver and kidney function,
☞psoriasis,
☞spastic colitis,
☞myasthenia gravis,
☞elderly age.

Side effects of the drug
➡From the cardiovascular system and blood (hematopoiesis, hemostasis):
☛bradycardia,
☛heart failure,
☛AV blockade,
☛hypotension,
☛violation of peripheral circulation,
☛thrombocytopenic purpura,
☛leukopenia,
☛agranulocytosis.

Interactions
Strengthens (mutually) the negative influence of verapamil and diltiazem on the myocardium, prolongs the action of nondepolarizing muscle relaxants, inhibits the excretion of lidocaine. Weaken the hypotensive effect of NSAIDs, glucocorticoids, estrogens, cocaine; strengthen – nitrates and other antihypertensive drugs. Heparin, antacids lower the level in the plasma; cimetidine and phenothiazines – increase. It is not recommended simultaneous administration with MAO inhibitors. Slows the metabolism of theophylline and increases its concentration in the blood plasma.

Method of application
Inside, squeezed with liquid or semi-liquid food (water, juice, apple puree, pudding), adults: with arterial hypertension – the initial dose – 80 mg twice a day, maintaining a dose of 160-320 mg. Prolonged forms: 80 mg once a day, if necessary up to 120-160 mg once, under the control of blood pressure. At arrhythmias – 10-30 mg 3-4 times a day, with subaortal stenosis – 20-40 mg 3-4 times a day.
With portal hypertension, angina, migraine, excitation, tremor, the initial dose of 40 mg 2-3 times a day, supporting – 160, 120-240, 80-160, 80-120, 80-160 mg / day, respectively. When pheochromocytoma – 30-60 mg / day for 3 days (before surgery). With myocardial infarction – from 5 to 21 days after a heart attack 40 mg 4 times a day for 2-3 days, then – 80 mg 2 times a day.
For the stimulation of labor – 20 mg every 30 minutes 4-6 times (80-120 mg / day), for the prevention of postpartum bleeding – 20 mg 3 times a day for 3-5 days. Children: Inside, the initial dose: 0.5-1 mg / kg / day, supporting – 2-4 mg / kg / day in 2 divided doses.

An overdose of a medicine
➡Symptoms:
➲dizziness,
➲bradycardia,
➲arrhythmia,
➲heart failure,
➲hypotension,
➲collapse,
➲difficulty breathing,
➲acrocyanosis,
➲convulsions.

➡Treatment: gastric lavage and the appointment of adsorptive agents, symptomatic therapy: atropine, beta-adrenomimetiki (isoprenaline, isadrin), sedatives (diazepam, lorazepam), cardiotonic (dobutamine, dopamine, epinephrine) drugs, vasopressor drugs, glucagon, etc .; it is possible to carry out transvenous stimulation.
Hemodialysis is ineffective.

Other recommendations
Treatment should be carried out under the supervision of a doctor. Reduces compensatory cardiovascular reactions in response to the use of general anesthetics. Intravenous introduction to children is not recommended. In elderly patients, the risk of CNS side effects is increased. When a violation of the liver is recommended to reduce doses. Can mask symptoms of hypoglycemia (tachycardia) in diabetic patients taking insulin and other hypoglycemic drugs. For the duration of treatment, it is recommended to exclude the use of alcoholic beverages. With caution apply during work drivers of vehicles and people whose profession is associated with increased concentration of attention. Stop the treatment gradually, for about 2 weeks. During the treatment, it is possible to change the test results when carrying out laboratory tests (increased levels of urea, transaminases, phosphatases, LDH).

Storage method
List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

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Product descriptionSafety INDICATIONS Fluoxetine is used for treating premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve mood.

Pharmachologic effect
Antidepressant group of selective serotonin reuptake inhibitors. Timoanalepticheskim and has a stimulating effect.
Selectively blocking reverse neuronal uptake of serotonin (5 HT) neurotransmission in the neurons of the central nervous system. Inhibition of reuptake of serotonin leads to increasing the concentration of the neurotransmitter in the synaptic cleft, and amplifies its effect on ppolongiruet postsinapticheskie petseptopnyeuchastki. By increasing serotonergic transmission, the mechanism of the negative membrane due fluoxetine inhibits neurotransmitter exchange. With prolonged use of fluoxetine inhibits the activity of 5-HT1 receptors. It has little effect on the reuptake of norepinephrine and dopamine.It has no direct effect on serotonin, m-cholinergic, histamine H1, and adrenergic receptors alpha. Unlike most antidepressants cause a decrease in postsynaptic activity of beta-adrenergic receptors.Effective with endogenous depression and obsessive-compulsive disorders. Has anorectic action can cause weight loss. It does not cause orthostatic hypotension, sedation, nekardiotoksichen. Persistent clinical effect occurs within 1-2 weeks of treatment.

Pharmacokinetics
When administered drug is well absorbed from the gastrointestinal tract (up to 95% of the dose), the use of food slows the absorption of fluoxetine significantly. Cmax plasma levels are reached in 6-8 hours. The bioavailability after oral administration of fluoxetine is greater than 60%. The drug was well accumulates in the tissues, readily crosses the blood-brain barrier, binding to plasma proteins is 90%.It is metabolized in the liver by demethylation to the active metabolite nor fluoxetine and several unidentified metabolites. Excreted by the kidneys as metabolites (80%) and bowel (15%), mainly in the form of glucuronides. T1 / 2 fluoxetine after reaching equilibrium concentration in plasma is about 4-6 days. T1 / 2 of the active metabolite, nor fluoxetine with single dose and after reaching equilibrium concentration in the plasma is from 4 to 16 days. In patients with hepatic failure half-life of fluoxetine and norfluoxetine is prolonged.

Dosage
The drug is taken orally, at any time, regardless of the meal.
doldrums The initial dose is 20 mg 1 time / day in the first half of the day, regardless of meals. If necessary, the dose may be increased to 40-60 mg / day, divided into 2-3 doses (20mg / day weekly). The maximum daily dose – 80 mg 2-3 reception.The recommended dose is 20-60 mg / day.

Friend Interaktions
You can not use the drug simultaneously with MAO inhibitors, including antidepressants – MAO inhibitors; furazolidone, procarbazine, selegiline, and tryptophan (a precursor of serotonin), as may develop serotonin syndrome, which manifests itself in confusion, hypomania, agitation, convulsions, dysarthria, hypertensive crisis, chills, tremors, nausea, vomiting, diarrhea.

Conditions and terms
In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children. Shelf life – 3 years.

Indications.
– Depression of various origins;
– Obsessive-compulsive disorder;
– Bulimic neurosis.

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– gout.

Your doctor is entitled either to change your treatment including dose adjustments and administration frequency or even to prohibit you from taking Lasix if you have any of the above mentioned conditions.
Lasix is not to be used when urination is impossible for some medical or other reasons.
If you have lately had an MRI or any other kind of a scan, you should tell your doctor about that.

Can Pregnant Women Take Lasix?

If you are planning to become pregnant or already pregnant, you should think twice before you buy furosemide online. Lasix belongs to pregnancy category C introduced by FDA. What does this mean? Scientific studies have not yet confirmed or refuted possible harm Lasix may do to an unborn baby.
You should also be careful if you are breast-feeding. Furosemide is reported to be capable of passing into mother’s milk, which may lead to bad health risks and consequences for a nursing baby. A breast feeding woman may also be faced with the risk of milk production slowdown in connection with furosemide.
In any case, you should listen to nobody but your doctor speaking to the point.

How to Take Lasix in a Proper Way?

The medicine is to be taken strictly according to your doctor’s prescription or recommendations. You should agree with the medical specialist on your dosage and frequency of medicine administration. Moreover, your doctor has the right to change your course of treatment in any direction if he finds this appropriate.
You may need to purchase some special pieces of medical equipment such as a medicine cup (a dose-measuring spoon) to measure your doses with. You can find one at the nearest pharmacy. It is strongly recommended that you don’t use a conventional table spoon for this purpose.
Since Lasix will make you urinate oftener, this may be fraught with the complete loss of fluid that means great harm to the body. You should add special potassium supplements and a daily needed amount of salt to your diet to avoid such a sort of problems. However, this all should be done by your doctor’s permission.
During the treatment you should see your doctor for regular blood tests.

What Are Lasix Possible Side Effects?

The following symptoms of an allergic reaction should serve you as a signal to stop your Lasix treatment at once:
– swelling;
– hives;
– difficulty breathing.

You should also cease your treatment if you have any of the following side effects:
– hearing loss and other hearing problems;
– low potassium or calcium;
– weight loss;
– pain (in the upper part of stomach, in chest);
– headache;
– abnormal skin reactions (pale skin, skin pain, etc.).

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What should a woman do when she is unable to become pregnant? Unfortunately, many women ask themselves such a question hoping that in 9 months they will admire their precious pieces of life holding them in their hands. Since there is a question, there should also be an answer.
Clomid (active substance – clomiphene) is a fertility medicine that contributes to ovulation in women by causing the pituitary gland to produce needed hormones. Female patients with polycystic ovary syndrome also buy Clomid to become able to ovulate. Polycystic ovary syndrome makes it impossible for a woman to have ovulation in a natural way.

What Should Your First Steps Be?

If you are planning to order Clomid without prescription, you should be aware of possible risks for your health. A certain medication can impose specific restrictions for a certain patient. Your future Clomid treatment will require explanation from a highly qualified medical specialist so that you will be able to avoid Clomid-related risks.
First of all, before you purchase Generic clomiphene without prescription, your doctor should clarify if you can take Clomid without any fears of health consequences.

You can’t if you have any of the following illnesses or conditions:
– an allergy to clomiphene;
– an ovarian cyst (that has nothing to do with polycystic ovary syndrome);
– abnormal vaginal bleeding;
– pituitary gland tumor;
– the history of liver conditions or current liver problems;
– an uncontrolled illness of your adrenal or thyroid gland;
– pregnancy.

Your doctor should also know whether you have uterine fibroids or endometriosis.
Before you buy clomiphene online and use your first dose, you should be sure that you are not pregnant.

Other questions you should discuss with your doctor are:
– if clomiphene is able to pass into milk;
– if you may face the risk of milk release slowdown (your doctor should know that you have a nursing baby);
– if you may face the risk of an ovarian tumor in connection with Clomid used for more than three treatment cycles;
– if you may have the chance of giving birth to twins or triplets;
– any other questions concerning instructions – your individual dosing or frequency.

What Are Common Clomid Instructions?

During the treatment you as a patient should follow a few simple rules:
Always abide by your doctor’s directions.
Never adjust your dosing or medicine administration frequency by yourself.
Have your health checked by the medical specialist on a regular basis within the treatment course. (Your doctor will carry out a few medical tests to make sure that you don’t have any harmful effects of treatment).
Begin taking the medicine on the fifth day of your menstrual period. The treatment course should last for 5 days.
Before embarking on another treatment cycle, have your pelvis carefully examined by your doctor.
Have sexual intercourse regularly during ovulation.
Never take Clomid for longer than 3 treatment cycles.
Each item mentioned above should be discussed with your doctor.

What Should You Avoid While Taking Clomid?

Clomiphene may affect certain brain cells for a while after you have taken a dose. This may result in vision changes – blurred vision. So, you shouldn’t then be engaged in activities that require that you see distinctly and clearly. Driving a car may be dangerous at this time. Vision changes are not dangerous, they disappear as time goes by, and can be regarded as a mild side effect.

What Are Clomid Side Effects?

You should seek emergency medical attention if you have:
– an allergic reaction to the active substance (swelling, hives, difficulty breathing);
– ovarian hyperstimulation syndrome (nausea, diarrhea, vomiting, difficulty in breathing, stomachache, bloating, abnormal heart rate, urinating problems);
– severe vision problems (light flashes, hypersensitivity to light);
– pain or pressure in pelvis area;
– severe vaginal bleeding.

The following side effects are common and less serious so that in the majority of cases they do not require medical attention:
– headache;
– stomach discomfort (mild);
– hot flashes;
– bleeding or spotting.

These are not complete lists of side effects Clomid may cause. Ask your doctor for more details.

Where to Buy Clomid?

If you are interested to know where to buy clomiphene, you will be likely to be pleased to hear that you can buy cheap clomiphene online at a very affordable price Clomid is well known for.
It won’t take you long to make an order online. To buy medicines on the Internet is very convenient and time-saving. Moreover, you’ll save much money if you do shopping online. You will be pleasantly surprised at the price clomiphene has.
Give up all the sad thoughts about the future of your family and buy Clomid online right now! You will soon see the effect running about the house!
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