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Active Ingredient: Tadalafil
Forzest is an oral drug, used for treating male impotence, also known as men’s erectile dysfunction.
INDICATIONS
Forzest (Tadalafil) is an effective treatment for men’s erectile dysfunction.
INSTRUCTIONS
Forzest tablets must be taken orally. Take Forzest about one hour before you plan to have sex. Beginning in about 30 minutes and lasts for up to 36 hours, Forzest can help you get an erection if you are sexually excited. If you take Forzest after a high-fat meal, the medicine may take a little longer to start working.
If you miss a dose of Forzest, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
DOSAGE
Use exactly as prescribed by your Health Provider.
STORAGEStore Forzest below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Forzest out of the reach of children and away from pets.This drug is supposed to be taken only at a need, and the dosage may be higher. Don’t you ever take more of preparation than is defined, as a result there may happen severe side effects. If you are curing with it, use this drug approximately 30 minutes before you will sexual experience; or use as ordered by your physician. This medicals influence of sexual possibility is supposed to continue up to 36 hours. Consequently, there is no need to take it more than once per day. If you take it properly each day, you may try sexual activity at any suitable time between your doses. You should not take more than one potion each day. Try not to eat grapefruit or drink its juice when are curing with this drug, except your physician insists it. Grapefruit juice can be a cause of enlargement of definite medications in your bloodstream.The impact of this medication stays for 24-36 hours which is a sufficient time to take opportunity of a satisfied sexual intercourse. His tablet makes the stream of blood in the penis smooth, consequently giving an erection. Erectile dysfunction is an outcome of the blocked blood flow to the male organ. The blockage here is the Pde5 which stops the erections enhancer chemical cGMP from entering the penis. Since, Forzest is available easily ad at an affordable price, it also helps a man gain back his lost manhood. This magic pill shows quick and long lasting results. It starts working on a man within 20 minutes and its effect lasts for about 24-36 hours. On consumption of Forzest pill, the blood vessels in the penile region broadens up to enable easy blood flow. The cGMP chemical gets released in the penile region again thus giving men stronger erections. Forzest is can be easily available online.
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Other names for this medication: Clobetasol
Temovate cream is used to reduce itching, redness, and swelling associated with many skin conditions.

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Store Temovate cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not use near an open flame. Keep Temovate cream out of the reach of children and away from pets.
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Avanafil – innovation among agents for the treatment of erectile dysfunction
Even faster effect, and even fewer side effects
Avana-100 – the very generic “young” for the treatment of impotence Stendra. The drug is actually able to “outdo” all brand tablet for the treatment of impotence.

Avanafil – the quick cure of all: it takes effect within 15 minutes after the decision. Other advantages Avana-100 is its power (one tablet of 100 mg Avanafil does not lose its effectiveness even in severe forms of impotence) and the almost complete absence of side effects (principally new technologies have allowed drug makers to reduce the level of such effects to 1%). Time of the drug – 6 hours.

What is Avana 100 mg?
Avana 100 mg – a drug for the latest generation of an erection. He developed a small company Vivus Inc, which is headquartered in Mountain View (Calif., USA). The drug has been declared as the first tool that can completely restore control over an erection within 15 minutes. Following approval in April 2012 FDA Avanafil went on sale under the trade names Spedra (in Europe) and Stendra (in the US). It has established itself as a safe and reliable fast-acting drug. Widespread prevented just too high a price.

The well-known pharmaceutical company in our Sunrise Remedies decided to make medicine more affordable. Scientists from this company created a generic drug Stendra, which is a complete analog of the “original”. From the American Indian Avanafil it differs only in a very low price. All other characteristics of the drug Stendra (generic) are similar. Thanks to the efforts of “Sunrise” men in the world had the opportunity to take advantage of high-quality medicines at a reasonable price.

What is better – or Stendra Avana?
As we have said, Stendra – US drug developed by Vivus. Avana – Indian counterpart. Essentially, the drug is one manufactured by different manufacturers. Avana-100 (Stand) gained more widespread due to the lower price. The efficiency and speed are the same as the “original” preparation. It is no wonder that most men prefer to Avana. Reviews confirm the high popularity of the drug.

Avana (generic): principle of action
The most high-speed drug for erectile considered generic Stendra. Guide says that it belongs to the group of PDE-5 inhibitors. Like other active substances from this category Avanafil inhibits specific enzyme phosphodiesterase (type 5). Healthy men PDE5 need to go to the quiet state after sex. If you have sexual dysfunction, an enzyme found in the blood constant.

To enhance erection quality needed to increase blood flow to the penis and relax the smooth muscles of the corpora cavernosa. This “engaged” cyclic guanosine monophosphate. The level of cGMP is constantly decreasing the enzyme PDE-5. Before scientists were challenged to create a drug that blocks the action of phosphodiesterase. As a result, the drug was invented Avana (generic). Responses indicate that high efficiency of the tool has a unique degree of security.

How long does the effect of 100 mg pills Avana?
Searching for a cure, which in a few minutes to restore an erection? Try generic Avana. Reviews about this drug is always only positive. It is rapidly absorbed and becomes effective immediately. The effect of the reception Avanafil in 75% of cases after 15 minutes. Avanafil concentration in the blood reaches a maximum at 1-1.5 h. The validity period of 5-6 hours.

Medicine Avana-100, which can be bought on this page are completely eliminated from the body in the form of neutral metabolites. It is metabolized in the liver (isozyme CYP3A4) and is excreted in the feces. Via the kidneys displayed no more than 12-15% of active ingredient.

Generic Stendra: indications for use
One of the newest drugs to improve erections – generic Stendra. Reviews show that Avanafil starts to act faster than other drugs. It is used to treat erectile dysfunction. It is a special condition of the body, in which a man is not able to achieve an erection. There are also cases when the excitement of the reproductive system occurs, but the penis does not reach the desired hardness. Erectile dysfunction is also called impotence. Previously, it was considered an incurable disease. Today it is easy to cope Avanafil. Reviews of generic Stendra indicate that the drug is like a lot of men.

Can I take Avana100 women?
Many people wonder if the solution to raise the female libido Avana-100. Reviews of some women talking about the effectiveness of drugs in this direction. In particular, women often say that after taking Avanafil significantly enhanced sexual desire and orgasm becomes stronger. But special research studied the effects of the drug on women, was conducted. It is unknown how Avanafil affects lactating and pregnant women. Therefore, at this time Avana-100 is indicated for use only men who have reached 18 years of age.

Generic Avana: how to use
High speed and efficiency has generic Avana 100. Buy at the lowest price you can online pharmacy “ShopStoyal”. We always have the most advantageous offers for regular customers and new customers. Dosing of the drug:

Take Avana 100 mg 15 minutes before anticipated sexual intimacy.
minimum dose – ½ tablet.
The recommended dose – 1 tablet.
During the reception, you can use alcohol (in small amounts), and fatty foods.
Reviews Generic Stendra show that abundant and fatty food on Avanafila performance is not affected.

Avana100: Dosage
For preparation Avana-100 daily dose should not exceed 200 mg of active ingredient (two tablets). Doctors recommend at the initial stages of erectile dysfunction limited to 50 mg (half tablet). Only if the effect will not be possible to pass on the whole tablet Avana. The drug has a high degree of safety and almost never cause side effects. However, when exceeding the maximum daily dose (200 mg) adverse reactions are not only more frequent, but also increase.

Stendra (Avana): CONTRAINDICATIONS
Before you buy Avana 100 mg, check the list of contraindications. The drug is banned for use to people who have sexual activity can lead to a heart attack or fainting.

There are also diseases in which you need to carefully take the drug Avana-100. Instruction is one of them:

stomach ulcer or bowel;
stroke or myocardial infarction;
uncontrolled high or low blood pressure;
Penis deformation (fibrosis, injury, Peyronie’s disease, etc.);
ischemic optic neuropathy;
multiple myeloma.
Note that one of the safest drug is generic Stendra. Customer reviews show that it can still create a situation ugrozhayuschuie health when combined with other drugs.

Therefore it is impossible to combine the technique with Avanafil:

medications containing nitrates;
inhibitors of CYP3A4;
medicines for high blood pressure;
alpha-blockers;
antihypertensive agents.
We have tried to collect as much information about the drug generic Avana. Price, location, reviews, the principle of action – on this page there are all the necessary information. However, over the reception Avanafila must always consult a doctor.

Avana 100mg: Compatibility with alcohol
The manufacturer allows the use of small doses of alcoholic beverages while taking pills generic Avana 100. Responses indicate that a moderate amount of ethanol does not interact with the drug. But do not abuse alcohol. Alcohol promotes vasodilation. Avanafil has the same effect. As a result, blood pressure (especially in people with hypotension) may drop dangerously. In addition, the combination with alcohol drink Stendry can cause more severe side effects.

Generic Stendra: side effects
Before you buy generic Stendra Avana, check the list of possible side effects. As is known, Avanafil has an unprecedented level of security.

However, in rare cases (mainly in non-compliance with instructions) can occur:

runny nose;
headache;
back pain or lower back;
a sore throat.
Reviews of generics Avana say that these reactions are temporary. They completely disappear within 2-4 hours.

Where to buy original Avana-100 on favorable terms?
This page contains all the information about Avana-100 preparation (instructions, reviews and other useful information). Buy it on the most favorable terms possible in our online pharmacy. We specialize in high-quality, proven generics. We have the lowest prices and the most fast delivery to any region. For the convenience of customers, we offer several options for the checkout:

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expert Opinion

When friends said they were abruptly tablets of Viagra, I did not believe. But I decided to try. For samples I ordered a package and went to the party to which I have just been invited. Avana is not afraid of wine and fatty foods (in reasonable quantities).

After drinking alcohol, I became a little more daring and quickly swallowed the pill. In a conversation with a woman it took me just 15 minutes. Further developments remember how sweet dream. Such power I still had. The night flew by like a flash. Well, it was Saturday. Then I could at least get some sleep. Now upakovochka Avanafila is constantly in my pocket. Certainly come in handy).

 

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Active Ingredient: Sildenafil
Viagra Plus is a new formulation of world-known medication enhanced with the most active and reliable herbs that give you a new feeling of unlimited potency, over-whelming desire and incomparable endurance.

INDICATIONS

Viagra Plus is indicated for the treatment of erectile dysfunction in men. Viagra Plus is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.

INSTRUCTIONS

Use Viagra Plus as directed by your doctor.

  • Take Viagra Plus by mouth with or without food. Viagra Plus may not work as quickly if you take it with a high-fat meal.
  • Viagra Plus is usually taken about 15-30 minutes before sexual activity. The effect usually lasts up to 4 hours.
  • Viagra Plus can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.
  • Do not take more than the recommended dose or take it more often than once daily, or as directed by your doctor.
  • If you miss a dose of Viagra Plus and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor.

Ask your health care provider any questions you may have about how to use Viagra Plus.

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Store Viagra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viagra Plus out of the reach of children.

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Active Ingredient: Sildenafil. One pill of Viagra Plus x 400mg contains only 25 mg of Sildenafil.

Other Ingredients:

Ginseng has traditionally been used for fighting fatigue, providing immune support. Ginseng helps maintain stamina and energy levels and may enhance physical performance. Ginseng stimulates and increases endocrine activity in the body. It promotes an increase in metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng increases erections, sexual desire and successful intercourse more successfully in comparison with placebo.

L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness, increase of blood flow, L-Argine improves blood vessel function and stimulates the release of human growth hormone and prolactin.

Vitamin B-6 is an antioxidant nutrient that helps the body inhibit the formation of damaging free radicals. Excess homocysteine causes atherosclerosis (thickening and hardening of the artery walls) and an adequate supply of Vitamin B-6 will prevent the accumulation of this toxic metabolite. B-6 deficiency can weaken the heart muscle and raise serum cholesterol levels. Vitamin B-6 is very important for the metabolism of amino acids – most people should be taking some of this nutrient, this is why it activates L-Arginine in the most proper way.

Vitamin B-12 is necessary for the production of red blood cells and plays an important role in maintaining the health of nerve cells and in the formation of genetic material.

Folic Acid is an essential vitamin B that plays an important role in DNA and RNA synthesis, production of red blood cells, cardiovascular health, mood, mental functioning and maintenance of the nervous system. Adequate levels of folate help to maintain healthy levels of homocysteine, supporting cardiovascular health. The form of folate used in supplements is absorbed better than that found in foods.

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Vigra is the most well-known treatment for adult men with erectile dysfunction, sometimes known as impotence. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. Viagra is one of a class of drugs known as PDE-5 (Phosphodiesterase type 5) inhibitors. Viagra and the other PDE-5 inhibitors can help men with erectile dysfunction (male impotence) by enhancing the erectile response when a man is sexually stimulated.Sildenafil citrate is the generic version of the Viagra licensed since 2013 in the UK. Sildenafil is an effective, modern medicine used to treat erectile dysfunction (ED). When you take Sildenafil you may be able to:
You should take Viagra (Sildenafil) about one hour before you plan to have sex. Swallow the tablet whole with a glass of water. Viagra (Sildenafil) can be taken with or without food. However, you may find that Viagra (Sildenafil) takes longer to start working if you take it with a heavy meal. Viagra works by increasing the flow of blood to the penis which helps to obtain an erection hard enough for sex. Viagra has been clinically proven to help men with all degrees of erectile dysfunction. How does Viagra work?Viagra works by increasing the flow of blood to the penis which helps to obtain an erection hard enough for sex. Viagra has been clinically proven to help men with all degrees of erectile dysfunction. How long does it take for Viagra work? You should take Viagra about 1 hour before sexual activity. However, you may take it between 30 minutes to 4 hours before sexual activity if needed. Viagra can be taken with or without food. If you take Viagra ater eating a high fat meal, it may take a longer amount of time to take effect.Viagra is the most well known treatment for erectile dysfunction and it has been extensively studied in many clinical trials. It has been shown to be effective for 88% of men in improving their erections. If you are uncertain where to buy Viagra online and you are looking for safe, authentic Viagra that is manufactured by Pfizer Laboratories, I recommend AccessRx.com. They have been in business since 1998, are located in the USA in Tempe Arizona, and even offer overnight shipping. You can buy Viagra online without prescription in hand at AccessRx! These pharmacies have American doctors on staff to examine your medical records before they issue a prescription for Viagra. If you are a candidate for Viagra, your medication will be shipped straight to your door, overnight if necessary. How much does Viagra cost on these websites? They are all reasonably priced, but vary slightly from month to month. See the websites for their latest pricing before you buy Viagra online. Viagra 100mg x 10 pills =$423 | 20 pills =$813 | 30 pills = $1191 Genuine Viagra Only. No Generic Meds Sold at Apexrx.com Since 1999. Just like any other prescription medication Viagra should not be taken with other certain drugs, such as nitrates that people use for heart problems and chest pain. If you do, however, take a nitrate and Viagra at the same time – that can result in significant problems with blood pressure.
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INDICATIONS

Viagra is indicated for the treatment of erectile dysfunction in men. Viagra is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.

INSTRUCTIONS 

Use Viagra as directed by your doctor.

  • Take Viagra by mouth with or without food. Viagra may not work as quickly if you take it with a high-fat meal.
  • Viagra is usually taken about 1 hour before sexual activity; however, it may be taken anywhere from 4 hours to a half hour before sexual activity. Talk with your doctor about the best way to take Viagra.
  • Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.
  • Do not take more than the recommended dose or take it more often than once daily, or as directed by your doctor.
  • If you miss a dose of Viagra and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor.

DOSAGE

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Viagra may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

Ask your health care provider any questions you may have about how to use Viagra.

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Store Viagra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viagra out of the reach of children and away from pets.

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Inactive Ingredients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

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Clinico-pharmacological group
Drug for the treatment of benign prostatic hyperplasia. An inhibitor of 5α-reductase
Composition, structure and packing
Soft gelatin capsules, yellow, oblong, opaque, marked with the code * “GX CE2”.
1 caps. 500 mg dutas
Excipients: mono- and diglycerides of caprylic / capric acid – 349.5 mg BHT – 35 micrograms.
The composition of the capsule shell: gelatin – 144.8 mg, glycerol – 70.8 mg of titanium dioxide – 1.78 mg iron oxide yellow – 127 g, medium-chain triglycerides – qs, lecithin – qs, red ink for printing ** – qs
10 pieces. – Blisters (3) – packs cardboard.
10 pieces. – Blisters (9) – packs cardboard.
* Application code “GX CE2” in red ink used for printing in the manufacture of the finished dosage form production site Catalent France Beinheim SA (France); application code “GX CE2” gray with cold UV laser is used in the manufacture of the finished dosage form production site GlaxoSmithKline SA Rharmaceuticals (Poland).
** Red ink for printing used in the manufacture of the finished dosage form production site Catalent France Beinheim SA (France) and are not used in the manufacture of the finished dosage form production site GlaxoSmithKline SA Rharmaceuticals (Poland). The amount of ink in each capsule is less than 0.28 mg; materials remaining on the capsule are polyvinyl acetate phthalate, polyethylene glycol, propylene glycol, iron oxide red (E172, CI77491).

Pharmachologic effect
Drug for the treatment of benign prostatic hyperplasia. dutas – dual inhibitor of 5α-reductase. Inhibits the activity of 5α-reductase isozymes 1 and type 2, which is responsible for the conversion of testosterone to 5α-dihydrotestosterone (DHT). DHT is the primary androgen responsible for hyperplasia of glandular tissue of the prostate gland.
The maximum impact of dutas to reduce the concentration of DHT is dose dependent and is observed within 1-2 weeks after starting treatment. After 1 and 2 weeks dutas dose of 500 mg / day average dihydrotestosterone concentration in serum is reduced by 85% and 90%.

Pharmacokinetics
Suction
After a single dose of the drug in a dose of 500 mg of dutas serum Cmax is reached within 1-3 hours. The absolute bioavailability is about 60% relative to a 2-hour / infusion. The bioavailability of dutas is not dependent on food intake.
Distribution
Pharmacokinetic data obtained after single and multiple dutas, Vd indicates a large (300 to 500 liters). dutas has a high degree of binding to plasma proteins (> 99.5%).
When taken daily dutas concentration in serum reaches 65% of the steady-state level after 1 month and approximately 90% of that level in 3 months. Stationary dutas concentration in serum (Css), equal to about 40 ng / ml, achieved after 6 months of daily administration of 500 micrograms of the drug. Sperm as serum, dutas stationary concentrations also reached after 6 months. After 52 weeks of treatment, dutas concentrations in semen averaged 3.4 ng / ml (range 0.4 to 14 ng / ml). From the serum in the sperm gets approximately 11.5% of dutas.
Metabolism
In vitro dutas is metabolized by CYP3A2 isoenzyme to form two small monogidroksilirovannyh metabolites; however, it does not apply isoenzymes CYP2C9, CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2B6, CYP2C19 and CYP2D6. After reaching Css dutas, serum using mass spectrometric method exhibit unchanged dutas, 3 major metabolite (4′-gidroksidutasterid, 1,2-digidrodutasterid gidroksidutasterid and 6) and two small metabolite.
Withdrawal
In humans, dutas is extensively metabolized. After oral administration in a daily dose of dutas 500 mg to achieve Css from 1% to 15.4% (average 5.4%) of the dose is excreted through the intestines unchanged. The remaining part is excreted in the form of four major metabolites, constituting 39%, 21%, 7% and 7%, respectively, and 6 small metabolites (the share of each of which is less than 5%).
After a person has kidney excreted trace amounts of unchanged dutas (less than 0.1% of the dose).
When receiving therapeutic doses of dutas its final T1 / 2 of 3-5 weeks.
dutas is detected in serum (at concentrations greater than 0.1 ng / ml) up to 4-6 months after discontinuation.
Linearity / non-linearity
Pharmacokinetics dutas can be described as a process of first order absorption and elimination of the two parallel processes, a saturated (m. E. Depending on concentration) and one saturable (m. E. Does not depend on the concentration). At low concentrations in serum (less than 3 ng / ml) dutas rapidly excreted via elimination of two processes. After receiving a single dose of 5 mg or less, dutas is rapidly eliminated from the body and has a short half-life equal to 3-9 days.
At concentrations in serum above 3 ng / ml is slower clearance of dutas (0.35-0.58 l / h), primarily through the unsaturated linear process of elimination with the final T1 / 2 of 3-5 weeks. At therapeutic concentrations, against a background of daily intake of 500 micrograms prevails slower clearance of dutas; total clearance is linear and concentration-dependent character.
Older men
Pharmacokinetics and pharmacodynamics of dutas were studied in 36 healthy men aged 24 to 87 years after a single dose (5 mg) of the drug. Between the different age groups was not statistically significant differences in pharmacokinetic parameters such as AUC and Cmax. There were no statistically significant differences in the values of T1 / 2 of dutas men between the age groups 50-69 years and above 70 years, which includes the majority of men with benign prostatic hyperplasia.
Between different age groups had no significant differences in the degree of reducing the levels of DHT. These results demonstrate the absence of the need to reduce the dose of dutas in elderly patients.

Dosage
The drug can be taken regardless of meals.
The capsules should be swallowed whole, do not chew and do not open, because the contents of the capsule may cause irritation of the mucous membrane of the oropharynx.
Benign prostatic hyperplasia (BPH)
Adult males (including the elderly) The recommended dose of Avodart drug – 1 capsule (500 mg) 1 time / day. The capsules should be taken as a whole.
While improved during treatment with the drug comes pretty quickly, treatment should continue for at least 6 months in order to objectively evaluate the therapeutic effect.
For the treatment of BPH drug Avodart may be appointed as a monotherapy or in combination with alpha 1-blockers.
Special groups of patients
When receiving 500 mg / day via the kidneys excrete less than 0.1% of the dose, so there is no need to reduce the dose in patients with impaired renal function.
There is currently no data on the use of the drug Avodart in patients with impaired hepatic function. Because dutas is extensively metabolized and its half-life of 3-5 weeks, caution should be exercised in treating patients with drug Avodart impaired liver function.

Overdose
When assigning dutas to 40 mg / day once (up to 80 times higher than the therapeutic dose) for 7 days, significant side effects were noted. In clinical studies, patients within 6 months dutas received 5 mg daily, with no additional side-effects to those observed in patients receiving 500 mg of dutas, have been discovered.
dutas no specific antidote, so if you suspect an overdose quite symptomatic and supportive care.

Drug Interactions
In vitro dutas is metabolized by CYP3A4 isoenzyme cytochrome P450 enzyme system. In the presence of inhibitors of CYP3A4 dutas concentration in the blood can increase.
With simultaneous use of dutas with CYP3A4 inhibitors verapamil and diltiazem there is a decrease in clearance of dutas. However, amlodipine, another calcium channel blocker, does not reduce the ground clearance of dutas. The reduction in clearance of dutas and the subsequent increase in its concentration in the blood, while the use of this drug and CYP3A4 inhibitors is not significant due to the wide range of security boundaries dutas, so there is no need to reduce the dose.
In vitro dutas is not metabolized following cytochrome P450 isozymes person: CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2C9, CYP2C19 and CYP2D6.
dutas does not inhibit the enzyme in vitro system of human cytochrome P450 involved in the metabolism of drugs.
In vitro dutas does not displace warfarin, acenocoumarol, phenprocoumon, diazepam and phenytoin from their binding sites to plasma proteins, and these drugs are, in turn, do not displace dutas.
When conducting studies of the interaction of dutas with tamsulosin, terazosin, warfarin, digoxin and kolestiraminom a person of any clinically significant pharmacokinetic or pharmacodynamic interactions were observed.
In the application of dutas in conjunction with lipid-lowering drugs, ACE inhibitors, beta-blockers, calcium channel blockers, corticosteroids, diuretics, NSAIDs, inhibitors of phosphodiesterase type 5 and quinolone antibiotics any significant drug interactions were observed.

Pregnancy and lactation
Effects on fertility
Effect of dutas in a daily dose of 500 micrograms of sperm characteristics was studied in healthy volunteers aged 18-52 years. By 52 weeks of treatment the mean percent reduction in total sperm count, semen volume and sperm motor activity were 23%, 26% and 18% respectively compared to baseline. The concentration of spermatozoa and their morphological characteristics do not change.
After 24 weeks of observation of the average value of the percentage change in total sperm count in the group of dutas remained 23% lower compared to the baseline. The average value for all semen parameters at all time points remained within the normal range and did not meet the criteria for a clinically significant change (30%) at the 52 th week of treatment in two volunteers in a group of dutas total sperm count was reduced by more than 90% of Compared with baseline, with partial recovery at the 24 week follow-up.
Therefore, the clinical significance of the effect of dutas on the performance of individual sperm and fertility of the patient is unknown.
Pregnancy
dutas is contraindicated in women. dutas was not studied in women because Preclinical data suggest that inhibition of DHT levels can cause inhibition of the development of the external genitalia of the fetus.
Lactation
No data on the penetration of dutas passes into breast milk.

Side effects
Adverse events reported below are listed according to the anatomical and physiological classification and frequency of occurrence. The frequency of occurrence is defined as follows: very common (≥1 / 10), commonly (≥1 / 100 and <1/10), uncommon (≥1 / 1000 and <1/100), rarely (≥ 1/10 000 and < 1/1000), very rare (<1/10 000, including isolated cases). Frequency categories were formed on the basis of clinical studies and post-marketing drug surveillance.
The incidence of adverse events, formed the basis of post-marketing surveillance at
On the part of the immune system
Very rarely allergic reactions (including rash, pruritus, urticaria, localized edema) and angioedema
Skin and subcutaneous fat
Rarely, alopecia (hair loss mainly on the body), or hypertrichosis
Mental Disorders
Very rarely, depression
Reproductive system
Very rarely testicular pain, testicular swelling
The incidence of adverse events, formed on the basis of clinical trial data (adverse events related to the use of dutas monotherapy)
In the third phase, placebo-controlled trials with dutas compared with placebo, the researchers evaluated adverse events associated with taking dutas:
Adverse events of adverse events in the 1st year of application of adverse events in the 2nd year of application
Placebo
(n = 2158) dutas
(n = 2167) Placebo
(n = 1736) dutas
(n = 1744)
Erectile disfunktsiya2 3% 6% 1% 2%
Reduced libido2 2% 4% <1% <1%
Violation eyakulyatsii2 <1% 2% <1% <1%
Violations by zhelez1 infants <1% 1% <1% 1%
1 – including pain and breast enlargement.
2 – adverse effects from the reproductive system and mammary glands associated with the use of dutas (as monotherapy or in combination with tamsulosin). These adverse effects may persist after cessation of treatment and the effect of dutas on data retention adverse events is unknown.
Adverse events associated with the use of dutas in combination with tamsulosin
The following adverse events were reported in the study CombAT (comparison of dutas and tamsulosin 500 mg 400 mg 1 time / day as monotherapy or in combination for four years) and evaluated by researchers from the cumulative effect of ≥1%).
Adverse events of adverse events during the period of application of tamsulosin in combination with dutas
1st year 2nd year 3rd year 4th year
Kombinatsiya1 (n) (n = 1610) (n = 1428) (n = 1283) (n = 1200)
dutas (n = 1623) (n = 1464) (n = 1325) (n = 1200)
Tamsulosin (n = 1611) (n = 1468) (n = 1281) (n = 1112)
Erectile disfunktsiya3
A combination of 6% 2% <1% <1%
dutas 5% 2% <1% <1%
Tamsulosin 3% 1% <1% <1%
Reduced libido3
The combination of 5% <1% <1% 0%
dutas 4% 1% <1% 0%
Tamsulosin 2% <1% <1% <1%
Violation eyakulyatsii3
The combination of 9% 1% <1% <1%
dutas 1% <1% <1% <1%
Tamsulosin 3% <1% <1% <1%
Violations of the thoracic zhelez2
The combination of 2% <1% <1% <1%
dutas 2% 1% <1% <1%
Tamsulosin <1% <1% <1% 0%
Dizziness
The combination of 1% <1% <1% <1%
dutas <1% <1% <1% <1%
Tamsulosin 1% <1% <1% 0%
1 – = combination of dutas 500 mg 1 time / day + tamsulosin 400 mg 1 time / day;
2 – including pain and breast enlargement;
3 – adverse effects from the reproductive system and mammary glands associated with the use of dutas (as monotherapy or in combination with tamsulosin). These adverse effects may persist after cessation of treatment. Effect of dutas on data retention adverse events is unknown.

Conditions and terms
The drug should be stored out of reach of children at or above 30 ° C. Shelf life – 4 years.
Indications
– As monotherapy for the treatment and prevention of the progression of benign prostatic hyperplasia by reducing its size, relief of symptoms, improved urination, reduce the risk of acute urinary retention and the need for surgical intervention;
– As a combination therapy with alpha 1-blockers for the treatment and prevention of the progression of benign prostatic hyperplasia by reducing its size, alleviation of symptoms, improvement of urination, decrease the risk of acute urinary retention and the need for surgical intervention. Mainly I studied the combination of dutas and tamsulosin alpha1-blocker.
Contraindications
– Hypersensitivity to dutas, and other ingredients;
– Hypersensitivity to other inhibitors of 5α-reductase.
Avodart is contraindicated in women and children.
Precautions should be prescribed the drug for liver failure.

Special instructions
dutas is absorbed through the skin, so women and children should avoid contact with damaged capsules. In case of contact with damaged capsules should immediately rinse the appropriate site with soap and water.
Abnormal liver function
There is currently no data on the use of the drug Avodart in patients with impaired hepatic function. Because dutas is extensively metabolized and its half-life of 3-5 weeks, caution should be exercised in treating patients with drug Avodart impaired liver function.
Heart failure is the combined use of dutas and tamsulosin
The two 4-year clinical trials, the incidence of heart failure was higher in patients treated with the combination of dutas and alpha1-adrenergic blocker, primarily tamsulosin, than patients who had not received the combined treatment. In these two studies, the incidence of heart failure has remained low (≤ 1%) with some variability in between. But overall performance discrepancies frequency side effects of the cardiovascular system were noted. A causal relationship between treatment with dutas (alone or in combination with alpha1-blocker) and the development of heart failure has been established.
The impact on the identification of prostate-specific antigen (PSA) and prostate cancer (PCa)
Patients need to carry out a digital rectal examination, as well as use other methods of investigation of the prostate prior to treatment with dutas and repeat them periodically during treatment to rule out prostate cancer development.
Determination of the concentration of PSA in serum is an important component of screening aimed at identifying prostate cancer. After 6 months of therapy with dutas average serum PSA level is reduced by about 50%. Patients taking dutas should be defined a new basic PSA levels after 6 months of therapy. In the future, it is recommended to regularly monitor PSA levels.
The use of dutas did not affect the diagnostic value of PSA as a marker of prostate cancer. Any confirmed increase in PSA with respect to the least of its value in the treatment of dutas may indicate the development of prostate cancer (particularly prostate cancer with a high degree of differentiation by Gleason score) or nonadherence dutas should be carefully evaluated, even if the PSA levels remain within the normal range for this age group of patients not taking inhibitors of 5α-reductase.
Total PSA level returns to its original value within 6 months after discontinuation of dutas.
The ratio of free to total PSA remains constant even during therapy with dutas. If the determination of the percentage of free PSA fraction is further used to detect prostate cancer in men receiving dutas, correction of this magnitude is not required.
Effect of long-term use of dutas on the development of breast cancer in men
There were no long-term effect of dutas on the development of breast cancer in men.
Prostate cancer and high-grade tumors graduation
In the 4-year study (REDUCE) compared the use of placebo and dutas have 8231 volunteers aged 50 years to 75 years, with a negative biopsy in the presence of prostate cancer and a PSA level of 2.5 ng / ml to 10 ng / ml at the initial examination .
In the study, 6706 patients underwent a needle biopsy of the prostate gland and on the basis of the results determined by the degree of malignancy of prostate cancer Gleason. 1517 patients in the study were diagnosed with prostate cancer. In most cases, as in the dutas group and in the placebo group were diagnosed with well-differentiated prostate cancer (score Gleason 5-6). Differences in the number of prostate cancer cases with the assessment of 7-10 points Gleason in the dutas group and the placebo group were absent (p = 0.81).
4, it was observed more cases of breast cancer with the evaluation 8-10 Gleason dutas group (n = 29; 0.9%) compared with the placebo group (n = 19; 0.6%) (p = 0.15). When evaluating biopsy 1-2, the number of patients diagnosed with prostate cancer with an estimate 8-10 Gleason was comparable in groups dutas (n = 17; 0.5%) or placebo (n = 18; 0.5%). In assessing biopsy for 3-4 years it was diagnosed more cases of prostate cancer with the assessment of 8-10 points Gleason in the dutas group (n = 12; 0.5%) compared with the placebo group (n = 1, <0.1%) (p = 0.0035). The percentage of patients diagnosed with prostate cancer with an estimate 8-10 Gleason was stable during all time slots (the period of 1-2 years, and 3-4) in the group of dutas (0.5% in each period), while in placebo percentage of patients diagnosed with prostate cancer with 8-10 evaluation was lower for 3-4 years, 1-2 years than (<0.1% compared to 0.5% respectively).
In the 4-year study (CombAT) patients with BPH, in which prostate biopsy to all participants has not been determined protocol, and all diagnoses of prostate cancer based on a biopsy if indicated, with evaluation 8-10 prostate cancer Gleason was diagnosed in 8 patients (<0.5%) at dutas, 11 patients (<0.7%) with tamsulosin and 5 patients (<0.3%) in the combination therapy with tamsulosin and dutas.
A causal relationship between dutas and the development of prostate cancer a high degree of gradation is not established.
Men taking dutas should undergo regular examinations for assessing the risk of developing prostate cancer, including a PSA.
Effects on ability to drive vehicles and management mechanisms
dutas does not affect driving or using machinery.
If the kidney function
If the kidney function dose reduction is required (because while taking the drug at a dose of 500 mg / day with urine allocated less than 0.1% of the dose).
If abnormal liver function
It should be used with caution on patients with impaired liver function since dutas undergoes extensive metabolism in the liver, and its T1 / 2 of 3-5 weeks.
Precautions should be prescribed the drug for liver failure.
The use in the elderly
No dose adjustment is required.
Application in childhood
Avodart is contraindicated in children.
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Active Ingredient: sildenafil dapoxetine
Extra Super Viagra is used in the treatment of Erectile Dysfunction with Premature Ejaculation. Extra Super Viagra contains Sildenafil100 mg and Dapoxetine 100 mg.

 Product description

INDICATIONS
Extra Super Viagra is indicated for the treatment of erectile dysfunction in men.
INSTRUCTIONS
Use Extra Super Viagra as directed by your doctor.
Take Extra Super Viagra by mouth with or without food. Viagra may not work as quickly if you take it with a high-fat meal.
Viagra is usually taken about 1 hour before sexual activity; however, it may be taken anywhere from 4 hours to a half hour before sexual activity. Talk with your doctor about the best way to take Extra Super Delgra. Extra Super Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.
Do not take more than the recommended dose or take it more often than once daily, or as directed by your doctor.
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DOSAGE
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STORAGE
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MORE INFO:Extra Super Viagra
Active Ingredient: Sildenafil and Dapoxetine.

Safety information

Do NOT use Extra Super Viagra if:
you are allergic to any ingredient in Extra Super Viagra
you have been advised by your doctor to avoid sexual activity because of heart problems
you are taking nitrates (eg, isosorbide, nitroglycerin) in any form (eg, tablet, capsule, patch, ointment), or nitroprusside
you use certain recreational drugs called “poppers” (eg, amyl nitrate or nitrite, butyl nitrate or nitrite)
you take another PDE5 inhibitor (eg, tadalafil, vardenafil) or another medicine that contains sildenafil.
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if you have a history of liver or kidney problems, lung problems (eg, pulmonary veno-occlusive disease), high or low blood pressure, ulcers, bleeding problems, heart problems (eg, angina, aortic stenosis, heart failure, irregular heartbeat), or blood vessel problems
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What is Lexapro?
Lexapro belongs to the class of selective serotonin reuptake inhibitors. Lexapro affects unbalanced chemicals in the brain, causing depression.
Lexapro is used for treating depression.
Lexapro may be used for other purposes not listed in this medication guide.

APPLICATION Lexapro:
Take Lexapro exactly as directed by your doctor. To clarify the indications for use, contact your doctor or pharmacist.
Take each dose with a full glass of water (200 ml).
In order to accurately measure the dose, use a measuring spoon or cup, not a regular table spoon. Ask your pharmacist where you can get scoop / cup, if they do not.
Lexapro may be taken with or without food.
Typically, Lexapro taken once a day. Follow your doctor’s instructions. Take the medicine on a daily basis in the bottom and at the same time.
Do not stop taking Lexapro without consulting your doctor. Improvement can occur within a few weeks.
Store Lexapro at room temperature away from moisture and heat.

What should be discussed with your doctor before taking Lexapro?
Do not start treatment Lexapro if you are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 2 weeks. The interaction of these drugs with Lexapro can be dangerous.
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Zithromax is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. In children, it is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

 Product description

INDICATIONS

Zithromax is used for treating mild to moderate infections caused by certain bacteria. It may also be used alone or with other medicines to treat or prevent certain infections in persons with advanced HIV infection. Zithromax is a macrolide antibiotic. It slows the growth of, or sometimes kills, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

INSTRUCTIONS

Use Zithromax as directed by your doctor.

  • Take Zithromax by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
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  • Zithromax works best if it is taken at the same time each day.
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Ask your health care provider any questions you may have about how to use Zithromax.

STORAGE

Store Zithromax below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zithromax out of the reach of children and away from pets.

MORE INFO: Zithromax

Active Ingredient: Azithromycin.

Safety information

Do NOT use Zithromax if:

  • you are allergic to any ingredient in Zithromax, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin)
  • you are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zithromax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:if you are pregnant, planning to become pregnant, or are breast-feedingif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplementif you have allergies to medicines, foods, or other substancesif you have liver or kidney problems, myasthenia gravis, or abnormal heart rhythms.Some medicines may interact with Zithromax. Tell your health care provider if you are taking any other medicines, especially any of the following:Antiarrhythmics (eg, disopyramide, dofetilide ), arsenic, astemizole, cisapride, domperidone, maprotiline, methadone, paliperidone, pimozide, propafenone, quinolone antibiotics (eg, levofloxacin), terfenadine, or tetrabenazine because the risk of heart problems, including irregular heartbeat, may be increasedNelfinavir because it may increase the risk of Zithromax’s side effectsRifampin because it may decrease Zithromax’s effectivenessAnticoagulants (eg, warfarin), carbamazepine, cyclosporine, digoxin, ergot derivatives (eg, ergotamine), nilotinib, phenytoin, rifampin, theophylline, triazolam, or tyrosine kinase receptor inhibitors (eg, dasatinib) because the risk of their side effects may be increased by Zithromax.This may not be a complete list of all interactions that may occur. Ask your health care provider if Zithromax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Zithromax may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zithromax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Zithromax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zithromax. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Tell your doctor or dentist that you take Zithromax before you receive any medical or dental care, emergency care, or surgery.
  • Long-term or repeated use of Zithromax may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Be sure to use Zithromax for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Zithromax only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Zithromax should not be used in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zithromax while you are pregnant. It is not known if Zithromax is found in breast milk. If you are or will be breast-feeding while you use Zithromax, check with your doctor. Discuss any possible risks to your baby.
  • Side effects
  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Diarrhea; headache; loose stools; nausea; stomach pain; upset stomach; vomiting.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; changes in hearing or hearing loss; chest pain; eye or vision problems; irregular heartbeat; muscle weakness; pounding in the chest; red, swollen, blistered, or peeling skin; ringing in the ears; seizure; severe diarrhea; stomach cramps/pain; trouble speaking or swallowing; yellowing of the skin or eyes.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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