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Discount 10%: 879981.

Buy Rogaine(2%, 5%) online.

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Rogaine 2% is used to treat male pattern baldness in patients who are experiencing gradually thinning hair on the top of the head.

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Rogaine 5% is used to treat male pattern baldness in patients who are experiencing gradually thinning hair on the top of the head.

Rogaine: instructions for use and reviews.

Clinical and pharmacological group
The drug for the treatment of alopecia in men and women.

Active substance
Minoxidil.

Release form, composition and packaging
  Foam for external use 5% from white to yellowish-white in color, preserving the structure during the observation period of one minute.

Excipients: anhydrous ethanol – 536.3 mg, purified water – 314.1 mg, butylhydroxytoluene – 0.9 mg, lactic acid – 10 mg, anhydrous citric acid – 1 mg, glycerol – 20 mg, cetyl alcohol – 11 mg, stearyl alcohol – 5 mg, polysorbate 60 – 4 mg, propellant – propane / n-butane / isobutane% 48:30:22 – 50.2 mg.

  • 60 g – aluminum cylinders with a valve with a spray and a cap with a child protection system – polymer packaging.
    – the actual amount of minoxidil, without propellant, is 50 mg / g;
    – the actual amount of butylhydroxytoluene, without propellant, is 1 mg / g.

Pharmachologic effect
Being a peripheral vasodilator, minoxidil, when applied topically, enhances microcirculation in the area of ​​hair follicles. It stimulates the vascular endothelial growth factor, which is supposed to be responsible for the increase in capillary permeability, which indicates a high metabolic activity observed in the anagen phase.

Minoxidil stimulates hair growth in patients with hereditary hair loss (androgenic alopecia) in the initial and moderate stages. The exact mechanism of action of minoxidil for external use in hair loss is not fully understood.

Pharmacokinetics
Suction

When applied externally on intact skin, approximately 1–2% minoxidil solution undergoes systemic absorption.

In a clinical study, systemic absorption of 5% foam for external use was approximately half that of systemic absorption of a 5% solution for external use. The average values ​​of AUC0–12 h and Cmax with 5% foam were 8.81 ng × h / ml and 1.11 ng / ml, respectively, which corresponds to approximately 50% of the same values ​​when using 5% solution (18.71 ng × h / ml and 2.13 ng / ml, respectively).

Tmax with 5% foam is 5.42 hours and is similar to that with 5% solution (5.79 hours). The effect of minoxidil on hemodynamics is not expressed until the average serum concentration of minoxidil reaches 21.7 ng / ml.

Distribution

Although it was previously reported that minoxidil does not bind to plasma proteins, its reversible binding to human plasma proteins in the range of 37–39% was later demonstrated by in vitro ultrafiltration.

Since only 1–2% of topically applied minoxidil is absorbed, the degree of binding to plasma proteins observed in vivo after topical application will be clinically insignificant.

Vd of minoxidil after iv administration at a dose of 4.6 mg and 18.4 mg is 73.1 L and 69.2 L, respectively.

Metabolism

Approximately 60% of minoxidil absorbed after topical application is metabolized to form minoxidil glucuronide, mainly in the liver.

Breeding

T1 / 2 minoxidil for external use averages 22 hours, compared with 1.49 hours for oral use. 97% of minoxidil and its metabolites are excreted by the kidneys and 3% through the intestines.

After discontinuation of the drug, approximately 95% of minoxidil, applied topically, is excreted within 4 days.

Indications

  • androgenic alopecia in men and women.
    Contraindications
  • violation of the integrity of the skin of the head;
  • dermatoses of the scalp;
  • the simultaneous use of other drugs on the scalp;
  • pregnancy;
  • lactation (breastfeeding);
  • age up to 18 years;
  • age over 65;
  • Hypersensitivity to minoxidil or other components of the drug.

With caution, the drug should be prescribed to patients with cardiovascular diseases, arrhythmia, renal and liver failure.

Dosage
The drug is intended for external use. Before using the drug Rogaine , the hair and skin of the scalp should be thoroughly dried.

For the effectiveness of the drug and its achievement of the hair follicles, it is important to apply the drug to the skin of the scalp, and not to the hair.

For men, 1 g (1/2 cap) of foam is applied 2 times / day (morning and evening) on ​​the affected areas of the scalp. Rogaine should not be used more often than once every 12 hours. The total daily dose should not exceed 2 g of the drug (100 mg of minoxidil).

For women, 1 g (1/2 cap) of foam is applied 1 time / day to the affected areas of the scalp. Do not use Rogaine more than 1 time / day. The daily dose should not exceed 1 g of the drug (50 mg of minoxidil).

Do not apply Rogaine to other parts of the body.

Balloon recommendations

  1. Rotate the cap so that the arrows on the spray gun and cap are aligned.
  2. Tilt the cap back and remove it.
  3. Before squeezing the foam, it is recommended that you first rinse your fingers with cold water and dry thoroughly, as Upon contact with warm skin, the foam may dissolve.
  4. Turning the can upside down, press the spray gun and squeeze the required amount of foam onto your fingers.
  5. Distribute the foam with your fingertips over the areas of baldness and gently rub into the skin of the scalp.
  6. After using Rogaine , put a cap on the bottle. To keep the packaging safe from accidental opening by children, make sure that the arrows on the spray gun and cap are not aligned.

After applying Rogaine , wash your hands thoroughly.

The appearance of the first signs of suspension of hair loss and restoration of hair growth is possible after the use of the drug Rogaine 2 times / day in men for 2–4 months and 1 time / day in women for 3–6 months.

To achieve and maintain the achieved effect of restoration of hair growth, the patient should not interrupt the use of the drug, otherwise hair loss will resume.

An increase in the dose of the drug or its more frequent use will not lead to an improvement in the results of therapy.

If after the use of the drug Rogaine in men for 16 weeks and in women for 24 weeks, there is no increase in hair growth, then the drug should be discontinued.

After you start using Rogaine, you may experience increased hair loss. This effect is caused by the influence of minoxidil. It is expressed in stimulating the transition of hair from the resting phase (telogen) to the growth phase (anagen). Thus, there is a loss of old hair, in the place of which new ones grow. Temporary enhancement of hair loss usually lasts for 2-6 weeks from the start of treatment, and then decreases for 2 weeks.

Side effects
The frequency of adverse reactions is given in the form of the following gradation: very often (≥1 / 10); often (≥1 / 100, <1/10); infrequently (≥1 / 1000, <1/100); rarely (≥1 / 10,000, <1/1000); very rarely (<1/10 000), including individual messages of unspecified frequency (frequency cannot be calculated from the available data).

Adverse events reported in clinical trials

From the nervous system: often – headache.

On the part of the skin and subcutaneous tissues: often – skin itching, rash; rarely – dermatitis, manifested in the form of redness, peeling and inflammation.

Post-marketing data

Allergic reactions: very rarely – angioedema (swelling of the lips, swelling of the tissues of the oral cavity, swelling of the oropharynx, swelling of the pharynx and swelling of the tongue), hypersensitivity (swelling of the face, generalized erythema, generalized skin itching, a feeling of tightness in the throat), allergic contact dermatitis.

From the nervous system: very rarely – dizziness, headache.

From the side of the organ of vision: very rarely – eye irritation.

From the cardiovascular system: very rarely – tachycardia, palpitations; infrequently – lowering blood pressure.

From the respiratory system: very rarely – shortness of breath.

From the digestive system: very rarely – nausea, vomiting.

On the part of the skin and subcutaneous tissues: very rarely – reactions at the place of use (these reactions can extend to the ears and face, include: itching, irritation, pain, rash, swelling, dry skin, erythema; however, in some cases, reactions may be more severe, including: exfoliation, dermatitis, blistering, bleeding, ulceration), temporary hair loss, hair color changes, violation of hair texture, hypertrichosis (unwanted hair growth outside the place of use).

Other: very rarely – peripheral edema, chest pain.

If any of the side effects indicated in the instructions are exacerbated or any other side effects not listed in the instructions are noted, the patient should be informed by the doctor.

Overdose
If doses exceeding the recommended are applied to large areas of the body or other parts of the body, in addition to the scalp, an increase in systemic absorption of minoxidil is possible, which can lead to the development of adverse events.

Symptoms: unwanted effects on the part of the cardiovascular system associated with sodium and water retention, as well as tachycardia, decreased blood pressure and dizziness.

Treatment: symptomatic and supportive therapy. Beta-blockers can be prescribed for the treatment of tachycardia, diuretics are used to eliminate edema. In the event of a decrease in blood pressure, a 0.9% sodium chloride solution should be administered iv. Sympathomimetic agents, for example, epinephrine and norepinephrine, which have excessive pacemaking activity, should not be used.

Drug interaction
There is a theoretical possibility of enhancing orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, but without clinical confirmation.

It is impossible to exclude a very slight increase in the content of minoxidil in the blood of patients with arterial hypertension who are taking minoxidil inside, in case of simultaneous use of the drug Rogaine, although relevant clinical studies have not been conducted.

It has been established that minoxidil for external use can interact with some other drugs for external use.

For external use, minoxidil should not be used simultaneously with any other drugs (GCS, tretinoin, anthralin) applied to the skin of the scalp.

The simultaneous use of minoxidil in the form of a foam for external use and a cream containing betamethasone (0.05%) leads to a decrease in the systemic absorption of minoxidil.

The simultaneous use of a cream containing tretinoin (0.05%) leads to an increase in the absorption of minoxidil.

The simultaneous application of minoxidil and topical preparations, such as tretinoin and dithranol, to the skin, which cause changes in the protective functions of the skin, can lead to increased absorption of minoxidil.

Special instructions
Before starting treatment with Rogaine , it is necessary to conduct a general examination, including the collection and study of a medical history. The doctor should make sure that the scalp is healthy.

Apply the drug Rogaine only to healthy skin of the scalp. You can not use the drug for inflammation, infection, irritation, soreness of the skin, as well as simultaneously with other drugs applied to the skin of the scalp.

You should not use the drug Rogaine in cases of sudden hair loss, focal alopecia, when alopecia develops after childbirth, in case of baldness caused by taking medications, malnutrition (iron deficiency, vitamin A), as a result of hair styling in “tight” hairstyles, as well as when the cause of hair loss is unknown.

With a decrease in blood pressure or the appearance of chest pain, palpitations, weakness or dizziness, a sudden inexplicable increase in body weight, swelling of the hands or feet, persistent redness or irritation of the scalp, the patient should stop using Rogaine and consult a doctor.

Some components of the drug can cause burning and irritation. In case of contact with sensitive surfaces (eyes, irritated skin, mucous membranes), rinse the affected area with plenty of cool water. The drug contains butylhydroxytoluene, cetyl and stearyl alcohol, which can cause local skin reactions (for example, contact dermatitis).

Accidental ingestion of the drug can lead to the development of serious adverse events from the heart. Therefore, this drug should be stored in places inaccessible to children.

The contents of the container are under pressure. Do not pierce or burn the cylinder. The product is flammable, so do not spray the contents of the container near an open flame, polished or painted surfaces. Avoid contact with open flames during use, storage and disposal. Do not heat the cylinder above 50 ° C. When applying the drug should refrain from smoking.

If a medicine has fallen into disrepair or has expired, do not pour it into wastewater or throw it into the street. It is necessary to put the medicine in a bag and put in a garbage container. These measures will help protect the environment.

Recommendations for the use of the drug in conjunction with hair care products

The drug will not be effective when used:

  • a hair dryer after applying foam to the scalp;
  • hair care products that can cause scarring, as well as deep scalp burns;
  • methods of hair care that require strong pulling of hair from the scalp (for example, weaving “tight” braids (brading) or a ponytail hairstyle).

There is no need to wash your hair to apply the drug. If you wash your hair before using the medicine, you need to dry your hair and scalp.

When using hair styling products, you must first apply the foam and wait until it dries, and then use hair styling products.

Shampooing is allowed at least 4 hours after applying the drug.

There is no data on the effect of dyeing, perming, hair straighteners on the effectiveness of the drug. Because perming and staining can cause scalp irritation, the following precautions are recommended:

  • before staining and / or perm, it is necessary to make sure that the drug was washed off the hair and scalp in order to avoid possible irritation of the scalp;
  • for best results, do not apply the drug on the same day as the chemical treatment of the hair;
  • after using any chemicals, do not apply the drug for 24 hours to make sure that the scalp is not irritated after perming and / or staining.

Influence on the ability to drive vehicles and control mechanisms

In connection with the possible development of headache, dizziness, eye irritation, caution should be exercised when driving vehicles and practicing certain activities that require an increased concentration of attention and speed of psychomotor reactions. When the occurrence of the described adverse events should refrain from performing these activities.

Pregnancy and lactation
The drug Rogaine in the form of a foam is contraindicated in women during pregnancy and during breastfeeding.

Use in childhood
The drug is contraindicated for use in patients under the age of 18 years.

With impaired renal function
With caution, the drug should be prescribed to patients with renal failure.

With impaired liver function
With caution, the drug should be prescribed to patients with liver failure.

Use in old age
The drug is contraindicated for use in patients over the age of 65 years.

Terms and conditions of storage
The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life is 3 years. Do not use the drug after the expiration date indicated on the package.

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