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Levitra
Brand Levitra
Vardenafil 20 mg
The drug comes in original packaging and instrutsiey in English. Plus, we’re always the price several times lower than in pharmacies, as convenience and delivery of complete anonymity!
Levitra – Vardenafil is a trade name, a new oral tablet means for probable stimulation and arousal of male erectile dysfunction.
The action of Levitra like Viagra – it also increases blood flow to the penis, helping to achieve an erection and maintain it, but in many cases possible Levitra will work more efficiently. As a result of many chemical tests proved the effectiveness of the drug Levitra, as a means of maintaining potency and possible stimulation and excitement of erectile dysfunction.

Levitra (Vardenafil) –

A more powerful impact of this chemical agent on the enzyme penile arteries PDE-5 allows to use it not only as a first-line treatment, but also as a drug of choice – when the ineffectiveness of other PDE-5 inhibitors – viagra(sildenafil) and cialis (tadalafil) .

this chemical agent “Levitra” and its generic forms of diabetic patients and in patients after radical prostatectomy is 72%, and men, previously unsuccessfully treated with Viagra (sildenafil) Contents komponentovlyaet 62%.

Levitra (Vardenafil) –

Levitra erectile dysfunction.

Levitra in patients with diabetes, prostatectomy resistant to other phosphodiesterase-5 inhibitors.

Levitra is reduced over time,

Levitra (Vardenafil) – the description of the chemical agent.

Levitra – a drug for the probable stimulation and arousal erectile dysfunction, phosphodiesterase type 5 inhibitors. It is used for the probability of stimulation and excitement erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse).

Latin name:

LEVITRA / LEVITRA.

The content of the components and the form of:

Levitra film-coated tablets, 1, 2, 3, 4, 6, 8, 9 or 12 pieces. packaged.

1 tablet contains vardenafil, Levitra 2.5, 5, 10 or 20 mg (5.926, 11,852 or 23,705 mg of vardenafil hydrochloride trihydrate, respectively).

The active-active components:

Vardenafil / Vardenafil.

Properties / Action:

Levitra – a drug for the probable stimulation and arousal erectile dysfunction, an inhibitor of phosphodiesterase type 5 (PDE5).

Penile erection is a hemodynamic process based on the relaxation of smooth muscles of cavernous bodies and located in its arterioles. During sexual stimulation likely nerve endings of the cavernous bodies released nitric oxide (N0), activating the enzyme guanylate cyclase, which results in an increase in the content of the cavernous bodies of cyclic guanosine monophosphate (cGMP). The result is relaxation of corpus cavernosum smooth muscle, which increases blood flow to the penis.
Levitra (vardenafil) blocks PDE 5, under the influence of which the breakdown of cAMP, as a result of the action of endogenous NO in the cavernous bodies during sexual stimulation likely amplified, resulting in the ability of Levitra enhances the natural effect on sexual stimulation.

Pharmacokinetics:

Once inside Levitra rapidly penetrates and takes effect in 15 minutes (in most men after 25 minutes), the duration of Contents komponentovlyaet 4-5 hours.

Cmax is reached, usually after an average of 60 minutes (from 30 to 120 minutes). The absolute bioavailability of Contents komponentovlyaet about 15%. When receiving Levitra (vardenafil) together with a diet containing a large amount of fat, the absorption rate decreases: time to reach Cmax in plasma (Tmax) is increased to 60 m, an average Cmax is reduced by 20% without any significant change in AUC. When receiving Levitra with conventional feed containing no more than 30% fat, vardenafil pharmacokinetic parameters (Cmax, Tmax, AUC) are not changed.

Vardenafil and its major metabolite are highly bound to plasma proteins (95%), and this property is reversible and not dependent on the total concentration of the chemical agent. After 90 min after administration vardenafil in semen of healthy men found no more than 0.00012% of the administered dose.

Vardenafil is metabolized primarily in the liver, with the participation of enzymes of the cytochrome P450 – CYP3A4, and CYP3A5 and CYP2C9.
Middle T1 / 2 vardenafil content komponentovlyaet 4-5 hours and the major metabolite – about 4 hours. The total clearance vardenafil content komponentovlyaet 56 l / h, the final T1 / 2 – about 4-5 hours. After oral administration of vardenafil as metabolites excreted mainly through the intestine – 91-95% of the dose, to a lesser extent by the kidneys – 2-6% of dose.
In healthy older men (65 and older) compared with younger (45 years and younger) are not noted a significant reduction in hepatic clearance of vardenafil. In men older AUC increased on average by 52%. The chemical research Levitra no difference between the efficacy and safety of elderly and young individuals.
Patients with minor (QC> 55-80 mL / min), moderate (creatinine clearance> 30-50 mL / min) and severe (creatinine clearance In patients on hemodialysis, pharmacokinetics of vardenafil has not been studied.

In patients with mild and moderate hepatic impairment Vardenafil clearance is reduced in proportion to the degree of liver dysfunction. Compared with healthy men, patients with minor hepatic impairment may increase in AUC and Cmax 1.2-fold, and at moderate hepatic dysfunction – 2.6 times.

In patients with severely impaired hepatic function The pharmacokinetics of vardenafil has not been studied.

Admission Regulations:

erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse).
Dosage and administration:

Inside. Levitra can be taken regardless of meals. Levitra possible will work only if a sufficient level of sexual stimulation probable.

The drug at the recommended dose of Levitra is 10 mg should be taken 25-60 minutes before sexual intercourse. The duration of action of Levitra Content komponentovlyaet 4-5 hours.

If there is no positive effect of the dose was increased to Levitra 20 mg (diabetes, prostatectomy).

In patients taking other drugs or conditions involving reduced metabolism of vardenafil, the dose of Levitra should Content komponentovlyat 2.5-5 mg.

The dose of 5 mg is recommended in elderly patients (over 65 years). Subsequently, depending on the efficacy and tolerability of Levitra dose may be increased to 10 mg.

In patients with moderate hepatic impairment there is a decrease in clearance of vardenafil, so the starting dose of Levitra should komponentovlyat Content 5 mg / day. In patients with minor hepatic impairment change the dosage of Levitra is not required.

Patients with mild, moderate and severe renal impairment change the dosage of Levitra is not required.

You should not take Levitra more than once a day.

The maximum recommended dose is 20 mg komponentovlyaet Contents 1 time per day.
Overdose:

Known cases receiving Levitra in a dose of 80 mg per day, which were accompanied by the development of serious adverse reactions. However, at the same time when used in a dose of 40 mg twice a day, there are marked pain without evidence of toxic effects on the nervous and muscular system.

Treatment: Symptomatic and supportive therapy. Since vardenafil is highly bound to plasma proteins, and only a small number of Levitra excreted by the kidneys, the effectiveness of hemodialysis is unlikely.
The anti Admission Regulations:

Levitra is not recommended for use in patients:

which sexual activity is contraindicated due to diseases of the cardiovascular system;

have had in the past 6 months, heart attack or stroke;

with very low blood pressure (systolic blood pressure at rest below 90 mm Hg. v.);

with uncontrolled high blood pressure;

with unstable angina;

with congenital prolongation of QT interval;

with aortic stenosis and idiopathic hypertrophic subaortal stenosis;

with severe hepatic insufficiency;

with end-stage renal disease requiring dialysis;

with hereditary degenerative diseases of the retina (eg, pigmentary retinopathy);

with anatomical deformation of the penis (contortion, cavernous fibrosis, Peyronie’s disease);

with diseases predisposing to priapism (sickle-cell anemia, multiple myeloma, leukemia);

with a tendency to bleeding and aggravation of ulcer disease;

hypersensitivity to any component of the chemical agent Levitra;

simultaneously applying nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate), or drugs, which are nitric oxide donators;

simultaneously applying the HIV protease inhibitors such as indinavir or ritonavir.

Levitra is not indicated for women and children up to 16 years.

Pregnancy and lactation:

Levitra is not intended for use in women.

Strong Side effects: as a rule, significantly or moderately expressed and are transient in nature.

In carrying out chemical tests of the chemical agent Levitra, there are side reactions were:

headache, dizziness, blurred vision, drowsiness, increased muscle tone;

indigestion, nausea, changes in functional “liver” tests, increased GGT;

“tides” of blood to the face, hypertension, syncope, myocardial ischemia, nosebleeds;

rhinitis, dyspnea;

anaphylactic reactions (including laryngeal edema), photosensitivity;

increase the level of creatine kinase, myalgia, back pain;
priapism.

Cautions and precautions:

Due to the fact that sexual activity is associated with a certain degree of fundamental risk before prescribing Levitra about erectile dysfunction is necessary to assess the state of the cardiovascular system of the patient.

Levitra (vardenafil) is not intended for use in children.
Effects on ability to drive vehicles and management mechanisms:

Before the appointment of Levitra in patients who control the means of transport and work with mechanisms necessary to clarify their individual effect on Levitra.

Drug Interactions:

Vardenafil is metabolized primarily in the liver with the participation isozymes of cytochrome P450, in particular – CYP3A4, as well as with some participation isozymes CYP3A5 and CYP2C9.
Some medicines may affect the metabolism of Levitra, in this regard, patients should consult a physician in case of appointment of a new drug. For example, patients taking cimetidine, ketoconazole, itraconazole, indinavir or ritonavir, the maximum dose of Levitra 5 mg Content komponentovlyaet. The dose of ketoconazole and itraconazole thus should not exceed 200 mg. In an application with the CYP3A4 inhibitor erythromycin did not exceed the maximum recommended dose of Levitra is 10 mg / day.

Avoid concurrent use of this chemical agent Levitra with nitrates (such as nitroglycerin, sodium nitroprusside) or blockers of alpha-adrenergic receptors (of the chemicals to the probable stimulation and excitement of benign prostatic hyperplasia and / or lowering blood pressure) as well as a joint application with the specified these chemical agents could lead to a sharp decrease in blood pressure and collapse.
Since PDE inhibitors affect the system of nitric oxide / cyclic AMP, PDE5 inhibitors may increase the hypotensive effect of nitrates.
Levitra should be applied not earlier than 6 hours after administration of alpha-blockers, and the dose should not exceed 5 mg. However, in combination with an alpha-blocker tamsulosin supplementation may coincide in time.
With simultaneous use of Levitra with glibenclamide, nifedipine, warfarin and digoxin were observed significant changes in the pharmacokinetics.
With the simultaneous use of Levitra with warfarin was not observed changes in prothrombin time and clotting factors.
With simultaneous use of Levitra with acetylsalicylic acid, antacids, ACE inhibitors (enalapril, captopril), beta-blockers (propranolol, atenolol, metoprolol, etc.), Diuretics, hypoglycemic these chemical agents (sulfonylureas and metformin), as well as histamine H2-receptor ranitidine and cimetidine pharmacokinetics of vardenafil has not changed.

In studies in humans, while the use of Levitra (vardenafil) with acetylsalicylic acid was not observed changes in bleeding time.

In studies on human platelets in vitro demonstrated that monotherapy vardenafil not inhibit platelet aggregation induced by various agonists platelets.
Since the safety and efficacy of combinations of Levitra with other agents likely to stimulation and arousal erectile dysfunction (sildenafil, tadalafil) has not been investigated, the use of such combinations is not recommended.

Storage conditions:

Store in a dry place at temperatures no higher than 30 ° C.

Shelf life: 3 years.

Conditions of supply of pharmacies – prescription.

Levitra – a drug for the probable stimulation and arousal erectile dysfunction, phosphodiesterase type 5 inhibitors. It is used for the probability of stimulation and excitement erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse).

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