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Antibiotic “Amoxil”: instructions for use, testimonials.
Active Ingredient: Amoxicillin.
Other names for this medication:
Acimox, Alfamox, Almodan, Aloxyn, Amix, Amoclen, Amoksicilin, Amopen, Amoram, Amox, Amoxi, Amoxicilina, Amoxicillinum, Amoxiline, Amoxisol, Amoxivet, Amoxypen, Amurol, Apo-amoxi, Bimoxan, Bristamox, Cipmox, Clamoxyl, Flemoxin, Flemoxon, Galenamox, Gimalxina, Hidramox, Hydramox, Larotid, Lupimox, Moxa, Moxicillin, Novamoxin, Nu-amoxi, Ospamox, Penamox, Penimox, Polymox, Raylina, Reloxyl, Rimoxallin, Robamox, Servamox, Sintedix, Solciclina, Stacillin, Sumox, Tolodina, Utimox, Velamox, Wymox, Zimox.
Pharmacology and pharmacokinetics
The main active substance of “Amoxil” is amoxicillin trihydrate. As auxiliary components, calcium stearate, potato starch and low molecular weight medical polyvinylpyrrolidone act. The main component, amoxicillin, is a broad-spectrum antibiotic that is part of the aminopenicillin group.
The substance is characterized by a bactericidal mechanism of action, which is an active suppression of the synthesis of the cell wall of bacteria sensitive to amoxicillin. In the sphere of influence of amoxicillin, there are such well-known gram-positive bacteria as staphylococcus and streptococcus.
The drug is active against a number of gram-negative and anaerobic microorganisms. In tandem with metronidazole, it affects bacteria that promote the development of peptic ulcer in the stomach and duodenum.
Getting inside the body, the antibiotic “Amoxil“, the instruction of which describes in detail all the information about the drug, is actively absorbed and after 2 hours reaches the maximum concentration in the blood serum. Half-life from the body is 1.5 hours. The drug appears through the kidneys almost unchanged (60-70%).
Since “Amoxil” has a wide sphere of influence, the patients taking the drug are people with a variety of diseases. Tablets “Amoxil” instruction recommends that patients suffering from respiratory tract infections: upper (tonsillitis, sinusitis, otitis media) and lower (pneumonia, bronchitis). It is also effective in the treatment of diseases of the bile duct and gastrointestinal tract.
Diseases of the urinary system are also amenable to “Amoxil“. Here we can talk about pyelonephritis, cystitis, asymptomatic bacteriuria in pregnant women. In addition, medical experts prescribe medication in the treatment of acute stages of uncomplicated gonorrhea, infections of the skin and soft tissues.
In addition, its combined (together with other drugs) application is possible and quite effective. “Amoxil” in tandem with clarithromycin or metronidazole is used for therapeutic therapy in diseases of the digestive system, provoked by the bacteria Helicobacter pylori (chronic forms of gastritis, stomach and duodenal ulcers).
Who is not recommended to take “Amoxil”?
Drug medication is contraindicated for people who are hypersensitive to the main active ingredient, auxiliary components, groups of penicillins and cephalosporins. Do not take this medication with mononucleosis and lymphocytic leukemia.
The joint appointment of “Amoxil” with metronidazole is unacceptable for diseases of the nervous system, deviations in the work of the hematopoiesis system. In the same tandem, it is not possible to prescribe a drug to patients younger than 18 years of age suffering from gastrointestinal diseases that are accompanied by prolonged vomiting or diarrhea.
Also, “Amoxil“, the instruction for the application of which describes in detail the contraindications to taking the drug, is forbidden to admit patients suffering from severe pathologies and abnormalities in the functioning of the liver. It is inadmissible to use alcohol during the combined treatment course.
Drug medication is manufactured by manufacturers in tablets with a dosage of 250, 500 and 625 mg. “Amoxil” is prescribed inside regardless of food intake. Dosage and treatment regimen is selected by the doctor taking into account the disease and the severity of the patient’s condition. For adults and children over 10 years of age (with a body weight of at least 40 kg), a single dose should be from 250 to 500 mg. In especially severe conditions, up to 1 gram of the drug “Amoxil” is prescribed.
Regardless of the patient’s age, the interval between doses should be at least 8 hours. In people with abnormalities in kidney function, the interval between doses should be increased to 12 hours. For individuals suffering from anuria, the daily norm of “Amoxil” can not exceed 2 grams.
In what cases is the drug “Amoxil-625″ prescribed? The instructions for use, in addition to all the above indications, recommend the use of this drug to suppress dental infections (including the treatment of dentoalveolar abscess), as well as joint and bone infections (including osteomyelitis). Effective medicament in this dosage for septic abortions, postpartum and intra-abdominal sepsis, burns, abscesses and wound infections.
Features of the application of “Amoxil”
In the process of treatment with medication (especially in high doses), experts recommend maintaining adequate diuresis. To avoid the development of crystalluria, it is necessary to take a sufficient amount of liquid.
Long-term use of “Amoxil” or repeated treatment with the same drug after a short period of time can give an impetus to the development of superinfections and to accelerate the growth of a stable microflora. Regardless of the dosage (250 mg or “Amoxil” 500), the instruction manual recommends that children maintain oral hygiene, since the main active ingredient is able to change the color of the tooth enamel.
Patients whose professional activities are associated with performing works that require high concentration of attention, “Amoxil” should be administered with caution, since side effects from the nervous system are possible.
During lactation it is undesirable to take this medicine, as it is excreted in breast milk, which can lead to sensitization of the baby (increased sensitivity to the active ingredient, the possibility of allergic reactions).
Any dosage of the drug, even Amoxil 250, is not recommended for women taking estrogen-containing contraceptives, since amoxicillin reduces their effectiveness. Slowed down the process of removing the drug through the kidneys, if in conjunction with “Amoxil” the patient takes indomethacin, acetylsallicyl acid (aspirin), sulfinpyrazone, oxyphenbutazone, phenylbutazone.
Exceeding the permissible dose
Symptoms of excess of a single dosage of medication are: nausea, vomiting, diarrhea, deviation from the norm of water electrolyte balance. To eliminate the consequences, gastric lavage is performed, the use of absorbent drugs (in particular activated charcoal), saline laxatives is prescribed, measures are taken to correct the water-electrolyte balance. In especially severe cases, a hemodialysis procedure may be required (purification of blood outside the kidneys).
Possible side effects
What side effects does the antibiotic “Amoxil” have? Instructions for use describe possible problems from various body systems.
The gastrointestinal tract can respond to the reception of “Amoxil” with nausea, vomiting, diarrhea. In more severe cases, it is possible to develop hemorrhagic or pseudomembranous colitis, candidiasis of the intestine. From the side of the urinary system, interstitial nephritis is often observed. Manifestations of the same disease can be expected from the hemopoietic system. Also sometimes thrombocytopenia, leukopenia, hemolytic anemia, crystalluria develops. A negative reaction to “Amoxil” from the side of the nervous system can be expressed in the appearance of convulsions, dizziness and the state of hyperactivity.
Sometimes there are all kinds of allergic reactions (rash, itching, hives, conjunctivitis, allergic vasculitis, angioedema).
What else is dangerous, “Amoxil”? Instruction, patient reviews and numerous studies confirm that the action of the drug can trigger the development of anaphylaxis, multiforme erythema, candidiasis of the mucous membranes and skin, cholestatic jaundice, hepatitis, Stevens-Johnson syndrome (malignant erythema).
“Amoxil” and angina
Angina in the people is called the infectious process, which manifests itself in the inflammation of the components of the lymphatic pharyngeal ring. Most often, tonsils are involved in the process. Inflammation is caused by streptococci or staphylococci. In most cases, to combat this bacterial disease, medical professionals prefer to use antibiotics penicillin group. One of these drugs is “Amoxil“.
Tablets instructions for use recommend appointing regardless of food intake. In this case, they should be swallowed whole and washed down with water. Usually the drug is taken at intervals of not less than 8 hours. However, the treatment regimen and dosage can be selected individually by the attending physician depending on the severity of the patient’s condition.
Pediatricians usually receive pediatricians for treatment of “Amoxil” 250. The instruction describes dosage regimens depending on the age and weight of the child. Babies under 2 years are usually prescribed a daily rate equal to 30 mg of the drug per kilogram of weight. The total dose should be divided into 3 doses. Children of the age group from 2 to 5 years once a day prescribed 125 mg of medicament.
Starting from the age of 5 and up to 10 years, a single daily intake is 250 mg. From 12 years old, one tablet (625 mg) is prescribed for adolescents from the age of 12 for the treatment of angina. The interval between doses is 12 hours.
To treat bacterial sore throat in adult patients, therapists prescribe “Amoxil” 500. The instructions for use describe the treatment regimen in the form of a single dose of 500 mg. In the case of a severe process, the doctor may prescribe a single dose of the drug to 1 gram. The maximum daily dose for angina should not exceed 6 grams. “Amoxil” at a dosage of 625 mg is often prescribed in the treatment of tonsillitis.
Tablets are taken once with an interval of 12 hours. If a patient suffers chronic renal failure, he is prescribed a dose of 625 mg once a day for angina. Patients on hemodialysis after taking the procedure additionally take 1 tablet of the drug.
!!!In any case, the scheme of therapy with the drug “Amoxil” with angina should be selected by the treating doctor.!!!
Interaction of “Amoxil” with other drugs
As mentioned earlier, the use of Amkosil by women using oral contraceptives is undesirable, since the effectiveness of the latter is reduced. In addition, the development of bleeding is possible. If the patient suffers from cardiovascular diseases (in particular, arrhythmia) and takes digoxin, simultaneous reception of “Amoxil” will strengthen it (digoxin) absorption.
With the simultaneous administration of drugs that have a bacteriostatic effect (macrolides, tetracyclines, chloramphenicol) and “Amoxil” medication, the instructions for use inform the patients that the bactericidal action of amoxicillin, the main active ingredient in Amoxil, will be neutralized. If, for any reason, there was a need for an intensive diuresis (abundant drinking and simultaneous use of diuretics), the concentration of medication in the body will be lowered.
With the simultaneous administration of “Amoxil” and “Allopurinol” (prescribed for patients with elevated levels of uric acid in the blood), the frequency of allergic reactions from the skin can increase. Unsuitable joint administration of antacids (medications intended for the treatment of acid-dependent gastrointestinal diseases by neutralizing the hydrochloric acid of gastric juice) and the drug “Amoxil” (tablets) is not desirable.
Instruction for use informs that in this case the absorption of amoxicillin will be reduced. Carefully appointed a complex method of “Amoxil” and anticoagulants (substances and medications that depress the blood clotting system and prevent thrombosis). In this case, continuous monitoring of prothrombin time is necessary, since the probability of bleeding is quite high. Manifestations from the digestive system in the form of diarrhea reduce the absorption of drugs, as a result of which the action of “Amoxil” worsens.
The use of this antibiotic can reduce the content of estradiol (the most active female sex hormone – estrogen) in the urine of pregnant women.
In any case, no matter how simple the patient might feel his illness, self-medication is an unacceptably frivolous attitude to one’s own health. A drug that successfully cured a sore throat to a colleague at work can cause a lot of side effects in another patient, starting with a rash on the skin and ending with irreversible lesions of certain organs and systems that can cost you not only health but also life.
The modern pharmaceutical market is so complex and diverse that only a highly qualified medical specialist is able to understand all these scientific terms, doses and schemes, and to develop a course of treatment therapy individually for each individual patient, taking into account his state of health, while minimizing the risk of side effects .
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