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Pharmacodynamics: Amoxicillin – broad-spectrum antibiotic from the group aminopenicillins. It has a bactericidal mode of action that is in the suppression of cell wall synthesis of susceptible bacteria. Active against such microorganisms: Gram-positive bacteria – Staphylococcus spp. (except for strains producing penicillinase), Streptococcus spp., (including Streptococcus pneumoniae), Bacillus anthracis, Corynebacterium diphtheriae (most strains), Erysipelothrix rhusiopathiae, Listeria monocytogenes; Gram-negative bacteria: Borrelia burgdorferi, Escherichia coli, Haemophilus influenzae, Klebsiella spp., Leptospira spp., Moraxella (Branhamella catarrhalis) (most strains), Neisseria gonorrhoeae, Neisseria meningitidis; Proteus mirabilis, Salmonella spp., Shigella spp., Treponema pallidum, Treponema pertenue; anaerobic bacteria: Eubacterium spp., Clostridium perfringens, Clostridium tetani, Peptostreptococcus spp., Peptococcus spp., Streptococcus faecalis.
In combination with metronidazole exhibits activity against Helicobacter pylori.
To amoxicillin-resistant microorganisms producing penicillinase. Inactive against mycobacteria, mycoplasma, Rickettsia, fungi, amoeba, plasmodium, viruses and also Pseudomonas aeruginosa and Proteus spp. (except P. mirabilis).
Pharmacokinetics Following oral administration of amoxicillin is well absorbed, reaching a maximum serum concentrations at 2 hours after administration. The half – 1.5 hours. Excreted unaltered by the kidneys (60 – 70%).
Method of use and dosage
The drug is taken by a doctor. Amoxil is prescribed inside (regardless of the meal). The dosage regimen of the drug individually. Single dose for adults and children over 10 years (with a body weight greater than 40 kg) is 250 – 500 mg in severe illness – 1 year
In patients with impaired renal function at creatinine clearance 15 – 40 ml / min. interval between doses should be increased to 12 hours; when anurii daily dose should not exceed 2 g in combination with metronidazole (1.5 g / day) daily dose of Amoxil tablets of 2.25 g (3 admission). Patients with severe renal impairment (creatinine clearance less than 30 ml / min.) And / or liver appoint 1 g per day of metronidazole and amoxicillin 1.5 g (2 admission).
For eradikatsii Helicobacter pylori prescribed amoxicillin 1 g 2 times a day with 0.5 grams metronidazole (or clarithromycin 0.5 g 2 times a day) and lansoprazole (omeprazole) in a standard dose of 7 days.
Children: For children aged 5 – 10 years the single dose is 250 mg; between the ages of 2 and 5 years – 125 mg; children under 2 years of drug administered in a daily dose of 30 mg / kg body weight. The maximum dose – 60 mg / kg per day.
For adults and children interval between doses of 8 hours.
In applying Amiksina possible:
• allergic reactions (urticaria, erythema, angioedema, rhinitis, conjunctivitis and in rare cases – fever, joint pain, eosinophilia; very rarely – anaphylactic shock);
• the part of the digestive tract (nausea, vomiting, diarrhea), development of superinfection.
When used in combination with metronidazole are possible:
• nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis, and in rare cases hepatitis, pseudomembranous colitis, interstitial nephritis, disorders of hematopoiesis;
• long-term use at high doses – dizziness, ataxia, loss of consciousness, depression, recurrent neuropathy, seizures.
Indications for use
Amoxil is prescribed for the treatment of infections caused by sensitive microorganisms including:
• upper respiratory tract infections (otitis, tonsillitis, sinucit);
• lower respiratory tract infections (bronchitis, pneumonia);
• infections of the biliary tract and the gastrointestinal tract;
• urinary tract infections (cystitis, pyelonephritis, asymptomatic bacteriuria in pregnant women);
• acute uncomplicated gonorrhea;
• infections of skin and soft tissue.
In combination with metronidazole or clarithromycin is used to treat diseases of the digestive tract, associated with Helicobacter pylori (chronic gastritis, peptic ulcer and 12 duodenal ulcer).
Interaction with other drugs
Amoxicillin decreases the effect of estrogensoderjath contraceptives. Strengthens the absorption of digoxin. Decreases clearance and increases the toxicity of methotrexate. Excretion by the kidneys slows aspirin, indomethacin, sulfinperazonom, oxyphenbutazone, phenylbutazone.
Symptoms of overdose include nausea, vomiting, diarrhea, disruption of water and electrolyte balance.
Treatment: gastric lavage, the use enterosorbents (activated charcoal), saline laxatives, correction fluid and electrolyte balance, if necessary, apply hemodialysis.
Features of use
Precautions should be prescribed during pregnancy. Excreted in breast milk, which may lead to sensitization of the child.
If the kidney function dose Amoxil should be set based on creatinine clearance.
Shelf life: Store in a dry, dark place at a temperature of 15 ° C to 25 ° C. Shelf life – 2 years.
Keep out of the reach of children.
Package: 10 tablets in blisters. 2 blisters in a pack.
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