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Other names for this medication:
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Propecia is a medicinal product that belongs to the group of inhibitors of 5-alpha-reductase, used to treat baldness in representatives of the strong half of humanity.

What are the composition and form of the preparation of Propecia?
The active component of the drug Propecia is represented by finasteride, the◦ amount of which is 1 milligram per tablet. Data on excipients of medicament are absent.
Propecia is produced in tablets of pink color, biconvex, rounded. Supplied in polyethylene bottles of 90 and in blisters for 10 pieces. You do not need a doctor’s prescription to◦ buy a medicine.

What means does Propecia have?
Medication Propecia is intended for the treatment of hair loss (alopecia) in the male type. I will clarify that the basis of this disease is the◦ toxic damage of the hair follicles male sex hormone – testosterone. Sometimes you can find the term androgenic and androgenetic alopecia, which is inherently the same disease.

The defeat of the hair follicles is due to the activity of dihydrotestosterone, which is a biologically active form of◦ the male sex hormone.

Finasteride – an active component of the drug, is able to suppress the◦ reactions of biological synthesis of this substance, as well as partially block its effects.

The suppression of dihydrotestosterone inhibits the progression of alopecia, slows the processes underlying hair loss. In some cases, even partial restoration of◦ hair follicles is possible.

The first results of treatment should not be expected too soon. As a rule, at least 3 months must elapse before a noticeable relief of◦ symptoms occurs. The degree of restoration of hair follicles depends on many factors, in particular, on age, the presence of metabolic diseases, bad habits and other factors.

The effect of the drug is short. After the end of treatment, for a certain period, measured by several months, hair loss will inevitably continue.

Information on the◦ rate of absorption of the active substance from the intestine, as well as its distribution in the body is absent.

What are the medicines Propecia indications for use?
Propecia is indicated as an agent for the treatment and prevention of◦ male hair loss. There are no other conditions involving the use of this drug.

Before starting treatment, you should consult a specialist for a comprehensive examination, primarily aimed at determining the level of dihydrotestosterone.

What are the tablets Propecia contraindications for use?
Propecia is contraindicated in the presence of the following conditions:

☞Pregnancy and lactation;
☞Age is less than 12 years;
☞Individual intolerance.

⚠Women should not resort to the use of◦ this medication. In addition, it is strongly recommended during pregnancy to avoid contact with the drug, even given that the active substance of◦ the dosage form is covered with a special coating.

What are Propecia’s use and dosage?
It is usually recommended to take 1 tablet of the drug a day, regardless of food. Do not crush or crush the medicine. If desired, it is acceptable to◦ take the tablet with a small amount of water. It is better to take medication at regular intervals.

As mentioned above, treatment should be of a lasting nature, as a rule, the◦ maximum therapeutic effect develops one year after the start of treatment. For detailed information on the timing of treatment, contact your doctor. Dosage adjustment for patients of◦ the older age group is not required.

Overdose from Propecia
Data on the manifestation of an overdose of the◦ drug Propecia instruction on the application does not lead, because they do not exist. Even taking 8 tablets per day for a long period of time did not lead to any negative symptoms.

However, taking a high dose of medication does not help to increase the therapeutic effect. It is also worth considering the rather high cost of a single package of a drug.

What are the side effects of Propecia?
In most cases, taking the medication is not accompanied by the◦ development of undesirable consequences. Nevertheless, in some cases, the following symptoms can not be avoided: a decrease in libido (level of sexual desire), erectile dysfunction, a decrease in the volume of ejaculate, allergic manifestations in the◦ form of itching, swelling of the face, tenderness in the testicles.

Special instructions
With the simultaneous administration of drugs used to treat prostatitis, for example, Proscar or its analogues, it is possible to enhance the◦ effect of the latter and increase the incidence of side effects. In most cases, a separate specialist consultation will be required.

Conclusion
To treat hair loss should follow a comprehensive campaign. To begin with, it is necessary to exclude any diseases that, one way or another, can lead to the◦ development of such symptoms. In addition, one should not write off the◦ importance of rational nutrition, the rejection of bad habits, the fight against stress.

In addition, combined methods of treatment, suggesting the use of drugs like Propecia, as well as the use of◦ ointment, cream and gel, are well proven.

The patient should be instructed to use the prescribed medication alone. Be healthy!

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Active Ingredient: Propranolol.

Other names for this medication:
N-propranolol.

Pharmacological action of the drug
Hypotensive, antianginal, antiarrhythmic, uterotonizing.
Blocks beta1 and beta2-adrenergic receptors, has a membrane-stabilizing effect. It reduces the heart rate, reduces the force of the heart and the need for myocardium in oxygen. Reduces cardiac output, renin secretion, arterial pressure, renal blood flow and glomerular filtration rate. After taking a single dose, the hypotensive effect lasts for 20-24 hours. With prolonged use reduces venous return, has a cardioprotective effect.
In patients with moderate form of hypertension – reduces the likelihood of developing IHD and cerebral strokes. With IHD reduces the frequency of seizures, increases the tolerance of physical exertion, reduces the need for nitroglycerin. It is most effective in patients of young age (under 40 years) with hyperdynamic type of circulation and with increased content of renin.
Increases the tone of the bronchi and contractility of the uterus (reduces bleeding during labor and in the postoperative period), increases secretory and motor activity of the gastrointestinal tract. It inhibits platelet aggregation and activates fibrinolysis. Inhibits lipolysis in adipose tissue, preventing the increase in the level of free fatty acids (the concentration of triglycerides in the plasma and the coefficient of atherogenity increase.)
Suppresses glycogenolysis, secretion of glucagon and insulin, the conversion of thyroxine to triiodothyronine .It reduces intraocular pressure, reduces the secretion of watery moisture. and almost completely absorbed from the digestive tract.It is almost completely associated with plasma proteins.Conducts in lung tissue, brain, kidneys, heart, passes through the parade succinic barrier, enters the breast milk. Excreted kidneys as metabolites.

Indications for prescription
Arterial hypertension, angina pectoris, sinus tachycardia (including hyperthyroidism), supraventricular tachycardia, tachysystolic atrial fibrillation, supraventricular and ventricular extrasystole, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, sympathoadrenal crisis in patients with diencephalic syndrome, neurocirculatory dystonia, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prophylaxis), ancillary treatment and pheochromocytoma (only in association with alpha-blockers), thyrotoxicosis (including preoperative) thyrotoxic crisis, primary uterine inertia, menopausal vasomotor symptoms of withdrawal syndrome; treatment of akathisia caused by neuroleptics.

Contraindications
Hypersensitivity, AV blockade of II-III degree, sinoatrial block, bradycardia (less than 55 bpm), sinus node weakness syndrome, arterial hypotension, acute and severe chronic heart failure, Prinzmetal angina, cardiogenic shock, obliterating vascular diseases, bronchial asthma.
For the duration of treatment, breastfeeding should be discontinued.

Restrictions on the use:
☞Chronic bronchitis,
☞emphysema,
☞diabetes mellitus,
☞hypoglycemia,
☞acidosis,
☞impaired liver and kidney function,
☞psoriasis,
☞spastic colitis,
☞myasthenia gravis,
☞elderly age.

Side effects of the drug
➡From the cardiovascular system and blood (hematopoiesis, hemostasis):
☛bradycardia,
☛heart failure,
☛AV blockade,
☛hypotension,
☛violation of peripheral circulation,
☛thrombocytopenic purpura,
☛leukopenia,
☛agranulocytosis.

Interactions
Strengthens (mutually) the negative influence of verapamil and diltiazem on the myocardium, prolongs the action of nondepolarizing muscle relaxants, inhibits the excretion of lidocaine. Weaken the hypotensive effect of NSAIDs, glucocorticoids, estrogens, cocaine; strengthen – nitrates and other antihypertensive drugs. Heparin, antacids lower the level in the plasma; cimetidine and phenothiazines – increase. It is not recommended simultaneous administration with MAO inhibitors. Slows the metabolism of theophylline and increases its concentration in the blood plasma.

Method of application
Inside, squeezed with liquid or semi-liquid food (water, juice, apple puree, pudding), adults: with arterial hypertension – the initial dose – 80 mg twice a day, maintaining a dose of 160-320 mg. Prolonged forms: 80 mg once a day, if necessary up to 120-160 mg once, under the control of blood pressure. At arrhythmias – 10-30 mg 3-4 times a day, with subaortal stenosis – 20-40 mg 3-4 times a day.
With portal hypertension, angina, migraine, excitation, tremor, the initial dose of 40 mg 2-3 times a day, supporting – 160, 120-240, 80-160, 80-120, 80-160 mg / day, respectively. When pheochromocytoma – 30-60 mg / day for 3 days (before surgery). With myocardial infarction – from 5 to 21 days after a heart attack 40 mg 4 times a day for 2-3 days, then – 80 mg 2 times a day.
For the stimulation of labor – 20 mg every 30 minutes 4-6 times (80-120 mg / day), for the prevention of postpartum bleeding – 20 mg 3 times a day for 3-5 days. Children: Inside, the initial dose: 0.5-1 mg / kg / day, supporting – 2-4 mg / kg / day in 2 divided doses.

An overdose of a medicine
Symptoms:
➲dizziness,
➲bradycardia,
➲arrhythmia,
➲heart failure,
➲hypotension,
➲collapse,
➲difficulty breathing,
➲acrocyanosis,
➲convulsions.

➡Treatment: gastric lavage and the appointment of adsorptive agents, symptomatic therapy: atropine, beta-adrenomimetiki (isoprenaline, isadrin), sedatives (diazepam, lorazepam), cardiotonic (dobutamine, dopamine, epinephrine) drugs, vasopressor drugs, glucagon, etc .; it is possible to carry out transvenous stimulation.
Hemodialysis is ineffective.

Other recommendations
Treatment should be carried out under the supervision of a doctor. Reduces compensatory cardiovascular reactions in response to the use of general anesthetics. Intravenous introduction to children is not recommended. In elderly patients, the risk of CNS side effects is increased. When a violation of the liver is recommended to reduce doses. Can mask symptoms of hypoglycemia (tachycardia) in diabetic patients taking insulin and other hypoglycemic drugs. For the duration of treatment, it is recommended to exclude the use of alcoholic beverages. With caution apply during work drivers of vehicles and people whose profession is associated with increased concentration of attention. Stop the treatment gradually, for about 2 weeks. During the treatment, it is possible to change the test results when carrying out laboratory tests (increased levels of urea, transaminases, phosphatases, LDH).

Storage method
List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

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Product descriptionSafety INDICATIONS Fluoxetine is used for treating premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve mood.

Pharmachologic effect
Antidepressant group of selective serotonin reuptake inhibitors. Timoanalepticheskim and has a stimulating effect.
Selectively blocking reverse neuronal uptake of serotonin (5 HT) neurotransmission in the neurons of the central nervous system. Inhibition of reuptake of serotonin leads to increasing the concentration of the neurotransmitter in the synaptic cleft, and amplifies its effect on ppolongiruet postsinapticheskie petseptopnyeuchastki. By increasing serotonergic transmission, the mechanism of the negative membrane due fluoxetine inhibits neurotransmitter exchange. With prolonged use of fluoxetine inhibits the activity of 5-HT1 receptors. It has little effect on the reuptake of norepinephrine and dopamine.It has no direct effect on serotonin, m-cholinergic, histamine H1, and adrenergic receptors alpha. Unlike most antidepressants cause a decrease in postsynaptic activity of beta-adrenergic receptors.Effective with endogenous depression and obsessive-compulsive disorders. Has anorectic action can cause weight loss. It does not cause orthostatic hypotension, sedation, nekardiotoksichen. Persistent clinical effect occurs within 1-2 weeks of treatment.

Pharmacokinetics
When administered drug is well absorbed from the gastrointestinal tract (up to 95% of the dose), the use of food slows the absorption of fluoxetine significantly. Cmax plasma levels are reached in 6-8 hours. The bioavailability after oral administration of fluoxetine is greater than 60%. The drug was well accumulates in the tissues, readily crosses the blood-brain barrier, binding to plasma proteins is 90%.It is metabolized in the liver by demethylation to the active metabolite nor fluoxetine and several unidentified metabolites. Excreted by the kidneys as metabolites (80%) and bowel (15%), mainly in the form of glucuronides. T1 / 2 fluoxetine after reaching equilibrium concentration in plasma is about 4-6 days. T1 / 2 of the active metabolite, nor fluoxetine with single dose and after reaching equilibrium concentration in the plasma is from 4 to 16 days. In patients with hepatic failure half-life of fluoxetine and norfluoxetine is prolonged.

Dosage
The drug is taken orally, at any time, regardless of the meal.
doldrums The initial dose is 20 mg 1 time / day in the first half of the day, regardless of meals. If necessary, the dose may be increased to 40-60 mg / day, divided into 2-3 doses (20mg / day weekly). The maximum daily dose – 80 mg 2-3 reception.The recommended dose is 20-60 mg / day.

Friend Interaktions
You can not use the drug simultaneously with MAO inhibitors, including antidepressants – MAO inhibitors; furazolidone, procarbazine, selegiline, and tryptophan (a precursor of serotonin), as may develop serotonin syndrome, which manifests itself in confusion, hypomania, agitation, convulsions, dysarthria, hypertensive crisis, chills, tremors, nausea, vomiting, diarrhea.

Conditions and terms
In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children. Shelf life – 3 years.

Indications.
– Depression of various origins;
– Obsessive-compulsive disorder;
– Bulimic neurosis.

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When a doctor says that a certain medicine is contraindicated, he means that it should not be used by a patient for some health reasons. So, when at your doctor’s office, you should share the list of your current and past medical conditions with the medical specialist. He will then determine whether it is safe for you to get started with treatment or not. So, before you order Priligy, you should keep in mind that the medicine may be contraindicated in you in case if you have:
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• a permanent pacemaker.
The medicine is strictly contraindicated in patients with moderate or severe hepatic impairment or an allergy to dapoxetine as well as in patients taking such CYP3A4 inhibitors as ritonavir, ketoconazole, and telithromycine. You need your doctor’s advice if you take SSRIs, thioridazine, monoamine oxidase inhibitors, tricyclic antidepressant, or serotonin-norepinephrine reuptake inhibitors.
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Different dosage should be used depending on the degree of PE. To buy Priligy 60 mg online means to improve such an index as the mean IELT standing for the mean intravaginal ejaculation latency time. However, dapoxetine 30 mg is normally enough for a patient with lifelong PE. In case of acquired PE, there is no difference.
Your individual dosing as well as a detailed schedule approved by your doctor should be specified in your Priligy prescription. You should strictly adhere to its guidelines if you order dapoxetine to treat your PE problem. In this case you will take full advantage of Priligy without serious side effects.
Generic for Priligy is intended for use by men aged from 18 to 64. The medicine should be taken from 1 to 3 hours before sexual intercourse. The effect comes rapidly prolonging IELT, increasing the sexual satisfaction and sense of control.
Compared to other PE drugs which suffer from drug accumulation in body, dapoxetine is eliminated from the body a few hours after its administration. This allows avoiding most of side effects other similar medicines have. This is the greatest advantage that determines PE patients to purchase dapoxetine online.

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When taking Priligy, a person may experience the following common side effects:
• dizziness;
• nausea;
• dry mouth;
• insomnia;
• diarrhea;
• headache.
If the above-listed symptoms are bothersome, call your healthcare provider immediately.
Compared to similar PE drugs which put patients at a high risk of developing sexual dysfunction, dapoxetine has much milder side effects of this type.
The best way to avoid side effects is to take a dose recommended by your doctor.

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There is no specific information whether the medicine can be taken by children or old patients equally well. In this case, a patient should take note of doctor’s recommendations.

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– irregular heartbeat;
– dizziness;
– light-headedness;
– difficulty speaking;
– disorientation;
– loss of balance.
Seek medical attention if some symptom is bothering you.

What are Motilium Possible Side Effects?

Motilium can cause not only desired medical effects, but also side effects which are different in their strength and duration. It’s vitally important to react to serious side effects by seeking immediate medical attention.

Less common serious side effects may include:
– swelling of the mouth;
– loss of muscle control;
– loss of balance.

Rare serious side effects may be:
– abnormal (pounding, fast, irregular or racing) heartbeat;
– swelling of legs, lower legs, face, hands.

You shouldn’t much worry about some mild side effects that may manifest at the beginning of the treatment as a body reaction to a new medicine unless they are bothersome. As you get used to Motilium, they will go away.

Less common of them are:
– hives;
– dry mouth;
– swelling of male breast;
– pain in the breast;
– breast milk release;
– skin itching;
– headache;
– menstrual irregularities;
– eye problems.

Rare mild side effects may be:
– palpitations;
– tiredness;
– weakness;
– nervousness;
– difficulty speaking;
– dizziness;
– hearburn;
– difficulties urinating;
– irritability;
– diarrhea;
– constipation.

All in all, side effects caused by Motilium are rather rare. If you are interested to know the complete list of undesirable effects, turn to your doctor for more information.

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Considering high modern levels of consumption of salt which is ingested as a solid part of different foods (chunk food, barbecue, etc.), it is vitally important to get rid of excess “white death” in good time. In this case Lasix comes in handy. A water pill of Lasix will help your body absorb only a small amount of salt it typically needs and not a bit more. Instead of accumulating in your body, excess salt will get out of the body during next urination.
People who suffer from kidney problems (such as nephrotic syndrome), liver conditions or congestive heart failure buy Lasix to treat edema (fluid retention). The medicine can be used for treating hypertension equally well.
The secret lies in an active substance called furosemide. It provides the whole effect.

Where to Buy Lasix?

The next question that may cross your mind after you have already made up your mind to buy Generic Lasix online may be where to buy furosemide. The most convenient thing about this is that you can freely order Lasix without prescription on the Internet at quite an affordable furosemide price. However, you should keep in mind that it is necessary to, first of all, ask your doctor for a piece of advice on your Lasix treatment unless you want unpleasant health consequences. Buy cheap Lasix if you are willing to cleanse your body. You can purchase cheap furosemide online.

Before Your First Lasix Dose

Before starting treatment, you should find out if Lasix is good and safe for you. Your doctor as a qualified medical specialist will help you in that. Prior to buying Generic Lasix without prescription you should be sure of minimal potential risks for your health. These risks may be dangerous and even life-threatening if you do without your doctor’s recommendations.

You should discuss your chances of successful treatment if you have any of the following illnesses and conditions:
– diabetes;
– liver disease (such as cirrhosis);
– kidney conditions;
– increased levels of cholesterol or triglycerides;
– low magnesium or potassium in blood;
– different types of urination problems (enlarged prostate, bladder conditions, etc.);
– lupus;
– gout.

Your doctor is entitled either to change your treatment including dose adjustments and administration frequency or even to prohibit you from taking Lasix if you have any of the above mentioned conditions.
Lasix is not to be used when urination is impossible for some medical or other reasons.
If you have lately had an MRI or any other kind of a scan, you should tell your doctor about that.

Can Pregnant Women Take Lasix?

If you are planning to become pregnant or already pregnant, you should think twice before you buy furosemide online. Lasix belongs to pregnancy category C introduced by FDA. What does this mean? Scientific studies have not yet confirmed or refuted possible harm Lasix may do to an unborn baby.
You should also be careful if you are breast-feeding. Furosemide is reported to be capable of passing into mother’s milk, which may lead to bad health risks and consequences for a nursing baby. A breast feeding woman may also be faced with the risk of milk production slowdown in connection with furosemide.
In any case, you should listen to nobody but your doctor speaking to the point.

How to Take Lasix in a Proper Way?

The medicine is to be taken strictly according to your doctor’s prescription or recommendations. You should agree with the medical specialist on your dosage and frequency of medicine administration. Moreover, your doctor has the right to change your course of treatment in any direction if he finds this appropriate.
You may need to purchase some special pieces of medical equipment such as a medicine cup (a dose-measuring spoon) to measure your doses with. You can find one at the nearest pharmacy. It is strongly recommended that you don’t use a conventional table spoon for this purpose.
Since Lasix will make you urinate oftener, this may be fraught with the complete loss of fluid that means great harm to the body. You should add special potassium supplements and a daily needed amount of salt to your diet to avoid such a sort of problems. However, this all should be done by your doctor’s permission.
During the treatment you should see your doctor for regular blood tests.

What Are Lasix Possible Side Effects?

The following symptoms of an allergic reaction should serve you as a signal to stop your Lasix treatment at once:
– swelling;
– hives;
– difficulty breathing.

You should also cease your treatment if you have any of the following side effects:
– hearing loss and other hearing problems;
– low potassium or calcium;
– weight loss;
– pain (in the upper part of stomach, in chest);
– headache;
– abnormal skin reactions (pale skin, skin pain, etc.).

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If you feel any other symptoms that bother you, seek emergency medical attention immediately.

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Analog.

What should a woman do when she is unable to become pregnant? Unfortunately, many women ask themselves such a question hoping that in 9 months they will admire their precious pieces of life holding them in their hands. Since there is a question, there should also be an answer.
Clomid (active substance – clomiphene) is a fertility medicine that contributes to ovulation in women by causing the pituitary gland to produce needed hormones. Female patients with polycystic ovary syndrome also buy Clomid to become able to ovulate. Polycystic ovary syndrome makes it impossible for a woman to have ovulation in a natural way.

What Should Your First Steps Be?

If you are planning to order Clomid without prescription, you should be aware of possible risks for your health. A certain medication can impose specific restrictions for a certain patient. Your future Clomid treatment will require explanation from a highly qualified medical specialist so that you will be able to avoid Clomid-related risks.
First of all, before you purchase Generic clomiphene without prescription, your doctor should clarify if you can take Clomid without any fears of health consequences.

You can’t if you have any of the following illnesses or conditions:
– an allergy to clomiphene;
– an ovarian cyst (that has nothing to do with polycystic ovary syndrome);
– abnormal vaginal bleeding;
– pituitary gland tumor;
– the history of liver conditions or current liver problems;
– an uncontrolled illness of your adrenal or thyroid gland;
– pregnancy.

Your doctor should also know whether you have uterine fibroids or endometriosis.
Before you buy clomiphene online and use your first dose, you should be sure that you are not pregnant.

Other questions you should discuss with your doctor are:
– if clomiphene is able to pass into milk;
– if you may face the risk of milk release slowdown (your doctor should know that you have a nursing baby);
– if you may face the risk of an ovarian tumor in connection with Clomid used for more than three treatment cycles;
– if you may have the chance of giving birth to twins or triplets;
– any other questions concerning instructions – your individual dosing or frequency.

What Are Common Clomid Instructions?

During the treatment you as a patient should follow a few simple rules:
Always abide by your doctor’s directions.
Never adjust your dosing or medicine administration frequency by yourself.
Have your health checked by the medical specialist on a regular basis within the treatment course. (Your doctor will carry out a few medical tests to make sure that you don’t have any harmful effects of treatment).
Begin taking the medicine on the fifth day of your menstrual period. The treatment course should last for 5 days.
Before embarking on another treatment cycle, have your pelvis carefully examined by your doctor.
Have sexual intercourse regularly during ovulation.
Never take Clomid for longer than 3 treatment cycles.
Each item mentioned above should be discussed with your doctor.

What Should You Avoid While Taking Clomid?

Clomiphene may affect certain brain cells for a while after you have taken a dose. This may result in vision changes – blurred vision. So, you shouldn’t then be engaged in activities that require that you see distinctly and clearly. Driving a car may be dangerous at this time. Vision changes are not dangerous, they disappear as time goes by, and can be regarded as a mild side effect.

What Are Clomid Side Effects?

You should seek emergency medical attention if you have:
– an allergic reaction to the active substance (swelling, hives, difficulty breathing);
– ovarian hyperstimulation syndrome (nausea, diarrhea, vomiting, difficulty in breathing, stomachache, bloating, abnormal heart rate, urinating problems);
– severe vision problems (light flashes, hypersensitivity to light);
– pain or pressure in pelvis area;
– severe vaginal bleeding.

The following side effects are common and less serious so that in the majority of cases they do not require medical attention:
– headache;
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– bleeding or spotting.

These are not complete lists of side effects Clomid may cause. Ask your doctor for more details.

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Analog.

Prednisolone is a hormonal drug, a glucocorticosteroid.

The formulation and composition of Prednisolone are produced by many pharmaceutical companies, with the same dosage of the active substance, the preparations can differ in appearance, in the content of the auxiliary components and in the package.

Dosage forms of Prednisolone with the active ingredient content:
tablets: color – white, form – planocylindrical;
➡active ingredient – Prednisolone, 1 tablet – 1 mg or 5 mg;
➡solution for injection (for intravenous and intramuscular administration):
➡slightly opalescent or transparent, slightly colored or colorless;
➡active ingredient – Prednisolone sodium phosphate (in terms of Prednisolone), in 1 ml – 15 mg or 30 mg;
➡ointment for external use 0,5%: color – white; active ingredient – Prednisolone, in 1 g – 5 mg;
➡eye drops 0.5%: white suspension; the active ingredient is Prednisolone acetate, in 1 ml – 5 mg.

Pharmacological properties
Pharmacodynamics
Prednisolone is a synthetic glucocorticoid, a dehydrogenated analog of hydrocortisone. Has anti-inflammatory, anti-allergic, desensitizing, anti-shock, antitoxic and immunosuppressive, antipruritic and antiexsudative effect.
Interacting with specific cytoplasmic receptors, Prednisolone forms a complex penetrating into the nucleus of the cell, stimulates the synthesis of matrix RNA (ribonucleic acid), which induces protein biosynthesis (including lipocortin), mediating cellular effects.

Inhibiting the enzyme phospholipase A2, lipocortin inhibits the release of arachidonic acid, as well as the synthesis of prostaglandins and leukotrienes, which contribute to inflammatory, allergic and other pathological processes.

Prednisolone inhibits pituitary release of β-lipotropin, but the concentration of circulating β-endorphin does not decrease, it inhibits the secretion of thyrotropin-releasing hormone (TSH) and FSH (follicle-stimulating hormone), increases the excitability of the CNS (central nervous system), reduces the number of lymphocytes, eosinophils, increases the number of blood cells , stimulating the production of erythropoietins.

Pharmacological action of the drug in systemic use (tablets, solution for injections in ampoules Prednisolone):
▶protein metabolism: reduces the content of globulin in the plasma, increasing the synthesis in the liver and kidneys of albumins (with an increase in the ratio of albumin / globulin);
▶increases protein catabolism in muscle tissue;
▶lipid exchange: stimulates the synthesis of triglycerides and higher fatty acids;
▶redistributes fatty deposits, moving them mainly to the face, shoulder girdle, abdomen;
▶can lead to the development of hypercholesterolemia;
▶carbohydrate metabolism: enhances absorption from the digestive tract (gastrointestinal tract) carbohydrates;
▶increases the intake of glucose from the liver into the bloodstream by increasing the activity of glucose-6-phosphatase;
▶increases the activity of FEPKK (phosphoenolpyruvate carboxylase) and improves the synthesis of aminotransferases by activating gluconeogenesis;
▶can lead to the development of hyperglycemia;
▶water-electrolyte balance: delays sodium and water in the body;
▶stimulates the excretion of potassium due to the increase in mineralocorticoid activity;
▶reduces absorption of calcium in the digestive tract, flushes calcium from bone tissue, increasing its excretion in the urine;
▶inflammatory processes: inhibits the release of inflammatory mediators by eosinophils and mast cells;
▶induces the formation of lipocortin and the reduction in the number of mast cells producing hyaluronic acid;
▶reduces the permeability of capillaries;
▶stabilizes cell membranes and membranes of organelles (especially lysosomal);
▶allergic reactions: suppresses the synthesis and secretion of mediators of allergy, inhibits the release of histamine and other bioactive substances from sensitized mast cells and basophils;
▶reduces the number of circulating basophils; suppresses the development of lymphoid and connective tissues;
▶reduces the number of mast cells, T- and B-lymphocytes;
▶oppresses the sensitivity of effector cells to mediators of allergy;
▶inhibits antibody formation;
▶changes the immune response of the body;
▶obstructive diseases of the respiratory tract: inhibits inflammatory processes, prevents or depresses the development of edema of the mucous membranes, inhibits eosinophilic infiltration of the submucosal layer of the bronchi epithelium and the deposition of immune complexes circulating in the mucous membrane of the bronchi;
▶stops erosion and desquamation of the mucosa;
▶increases the sensitivity of β-adrenoreceptors to endogenous catecholamines and exogenous sympathomimetics in bronchi of small and medium caliber;
▶reduces the viscosity of mucus by suppressing or reducing its production;
▶shock states, intoxications: increases blood pressure (arterial pressure) due to the increase in the concentration of circulating catecholamines and the restoration of receptor responsiveness to them, as well as the narrowing of the lumen of blood vessels;
▶reduces the permeability of the vascular wall, has a membrane-protective effect, activates liver enzymes involved in metabolic processes of endo- and xenobiotics;
▶immunosuppressive (immunosuppressive) therapy: inhibits the proliferation of lymphocytes (especially T-lymphocytes), suppresses B-cell migration and T-B and B-lymphocyte binding, inhibits the release of cytokines (interleukin-1 and -2, gamma-interferon) from lymphocytes and macrophages , reducing the formation of antibodies;
▶during the inflammatory process inhibits connective tissue reactions and reduces the possibility of keloid tissue formation.

Prednisolone with external application (ointment) has anti-inflammatory, antiallergic, antipruritic and anti-exudative effect; inhibits the formation of arachidonic acid, the formation and release of inflammatory mediators (prostaglandins, histamine, lysosomal enzymes, leukotrienes, etc.); suppresses inflammatory skin reactions, reduces vasodilation in the inflammation focus and increases vascular permeability.

Pharmacokinetics
Absorption of Prednisolone is high, with oral intake of tablets Prednazolone, the maximum concentration in the blood is reached after 1-1.5 hours. Up to 90% of the substance in the plasma binds to proteins: albumins and cortisol-binding globulin – transcortin.
The drug is metabolized in the kidneys, liver, bronchi, and small intestine. In oxidized forms, the substance is glucuronized or sulfated. Its metabolites are inactive.
T½ (half-life) is 2-4 hours, Prednisolone is excreted with bile and urine by glomerular filtration, 80-90% is reabsorbed by tubules, up to 20% is excreted unchanged by the kidneys. After intravenous injection of T1 Prednisolone from the plasma is 2-3 hours.
With topical application after absorption to the general bloodstream from the skin surface and from the conjunctival cavity, Prednisolone binds to plasma proteins and is metabolized predominantly in the liver; is excreted in the urine unchanged ≥ 20%, T½ is about 3 hours.

Indications for use Pills
↗endocrine pathologies: insufficiency of adrenal cortex primary and secondary (including post-ectomy state of adrenal glands), VGKN (congenital hyperplasia of the adrenal cortex), thyroiditis of de Kerven (subacute thyroiditis);
↗diffuse connective tissue diseases: SLE (systemic lupus erythematosus), rheumatoid arthritis, scleroderma, dermatomyositis, nodular periarteritis;
↗Rheumatic fever (rheumatic fever), acute rheumatic heart disease;
↗inflammation of the joints in acute and chronic form: humeroscapular periarthritis, Bechterew’s disease (ankylosing spondylitis), arthritis gouty and psoriatic, osteoarthritis (including post-traumatic), Still’s syndrome in adults, polyarthritis, juvenile arthritis, bursitis, synovitis, nonspecific tendosinovitis, epicondylitis;
↗allergic diseases in acute and chronic course: hypersensitivity reactions to food and medications, medicinal exanthemes, urticaria, serum sickness, pollinosis, allergic rhinitis, angioedema;
↗bronchial asthma, including asthmatic status;
↗diseases of the hematopoiesis and blood diseases system: acute lymphoid and myeloid leukemia, autoimmune hemolytic anemia, panmyelopathy, lymphogranulomatosis, agranulocytosis, thrombocytopenic purpura, secondary thrombocytopenia in adult patients, erythrocyte anemia (erythroblastopenia), erythroid (congenital) hypoplastic anemia;
↗skin diseases: eczema, pemphigus, exfoliative / atopic dermatitis, psoriasis, contact dermatitis (with lesions of large skin areas), diffuse neurodermatitis, toxicermy, Lyell’s syndrome (toxic epidermal necrolysis), seborrheic dermatitis, bullous herpetiform dermatitis, Stevens-Johnson syndrome (malignant exudative erythema);
↗eye diseases inflammatory and allergic: allergic conjunctivitis, allergic corneal ulcers, sympathetic ophthalmia, slow and severe uveitis of the anterior and posterior uveitis, optic neuritis;
↗Diseases of the digestive tract: ulcerative colitis, hepatitis, Crohn’s disease, local enteritis;
↗myeloma;
↗bronchogenic carcinoma (lung cancer): as part of complex treatment with cytostatics;
↗pulmonary pathologies: pulmonary fibrosis, acute pulmonary alveolitis, stage II-III sarcoidosis;
↗tuberculosis of the lungs, tuberculous meningitis;
↗aspiration pneumonia (as part of complex treatment with specific chemotherapy);
↗Leffler’s syndrome is not amenable to other types of treatment, berylliosis;
↗impaired renal function of an autoimmune nature (including acute glomerulonephritis), nephrotic syndrome;
↗multiple sclerosis; cerebral edema (including associated with surgery, radiation therapy, head trauma or a brain tumor) after prior application of parenteral forms of Prednisolone;
↗hypercalcemia due to oncological diseases; nausea and vomiting associated with cytotoxic therapy;
↗reaction of transplant rejection during organ transplantation – with a preventive purpose.

Injection
Prednisolone in the form of a solution for parenteral use is used, if necessary, for emergency therapy with the following conditions requiring a rapid increase in the concentration of glucocorticosteroids:
↗shock (traumatic, burn, operating, cardiogenic, toxic) – if vasoconstrictive agents, plasma-substituting drugs and other symptomatic treatment are ineffective;
↗allergic reactions in acute and severe forms, anaphylactic shock, hemotransfusion shock, anaphylactoid reactions;
↗cerebral edema (including associated with surgery, radiation therapy, head trauma or a brain tumor);
↗severe form of bronchial asthma, asthmatic status;
↗diffuse connective tissue diseases: SLE, rheumatoid arthritis;
↗thyrotoxic crisis; acute adrenal insufficiency;
↗acute hepatitis, hepatic coma;
↗poisoning with cauterizing fluids – to reduce inflammation and prevent scar scarring.

Ointment
Prednisolone ointment is used in the complex treatment of such inflammatory and allergic skin diseases of non-microbial etiology as eczema, neurodermatitis, psoriasis, lupus erythematosus, erythroderma, as well as allergic, seborrheic and contact dermatitis.

Eye Drops
↗blunt and sharp eye trauma;
↗keratitis (under the condition of complete intact epithelium of the cornea);
↗allergic blepharoconjunctivitis in chronic course;
↗uveitis of the anterior segment of the eye, sclerites, episcleritis;
↗postoperative period (in case of prolonged symptoms of irritation of the eyeball).

Contraindications
With short-term systemic use of Prednisolone according to vital indications, the only contraindication for its use is an increased individual sensitivity to the acting or auxiliary components.

Precautions Prednisolone in the form of tablets and a solution is prescribed for the following conditions / diseases:
↘infection and invasion of fungal, bacterial or viral origin (current or recent, including recent contact with an infected person): herpes simplex, chicken pox, herpes zoster (in the viremic phase), measles, systemic mycosis, strongyloidiasis, amoebiasis, tuberculosis in the active and latent phases. In severe infectious diseases, the use of Prednisolone is possible only against specific therapy;
↘perivac vaccine (8 weeks before vaccination and 2 weeks after), lymphadenitis after TB vaccine BCG (Bacillus Calmette-Guerin);
↘immunodeficiency conditions, including Acquired Immunodeficiency Syndrome (AIDS) or human immunodeficiency virus (HIV);
↘Gastrointestinal diseases: gastritis, peptic ulcer of stomach and duodenum, esophagitis, peptic ulcer in acute or latent flow, newly formed intestinal anastomosis, diverticulitis, ulcerative colitis with the threat of abscessing or perforation;
↘cardiovascular pathologies, including the recently transferred myocardial infarction (in patients with acute / subacute myocardial infarction, the focus of necrosis may be spread with a delay in the formation of scar tissue, which may result in a rupture of the heart muscle), hypertension, uncompensated chronic heart failure, hyperlipidemia;
↘endocrine disorders: thyrotoxicosis, diabetes mellitus (including a violation of carbohydrate tolerance), hypothyroidism, Itenko-Cushing’s disease, obesity 3-4 degrees;
↘renal / hepatic failure of severe degree, nephrourolythiasis;
↘hypoalbuminemia and predisposing to its appearance;
↘systemic osteoporosis, myasthenia gravis, poliomyelitis (exception – bulbar encephalitis), acute psychosis, glaucoma (open-angle and zakratougolnaya);
↘pregnancy.

Prednisolone ointment is contraindicated in bacterial, viral, fungal skin lesions, tuberculosis, syphilis, skin tumors, vulgar acne, rosacea, skin post-vaccination reactions, open wounds, trophic ulcers, in children under 1 year and with increased individual sensitivity to its components. With caution, ointment is used in pregnancy and lactation.

Contraindications to the use of eye drops Prednisolone:
↘increased intraocular pressure;
↘dendritic keratitis caused by Herpes zoster, chicken pox, other viral diseases of the cornea and conjunctiva;
↘Fungal, mycobacterial, acute purulent eye diseases;
↘corneal epitheliopathy;
↘hypersensitivity to the components of the drug.

Instructions for use Prednisolone: method and dosage
The dose of Prednisolone and the duration of treatment are selected by the doctor individually, depending on the indications and severity of the disease.

Pills
Tablets Prednisolone is taken orally, washed down with a small amount of liquid, in the morning (from 6 to 8 o’clock in the morning) at breakfast or immediately after it. Usually take a daily dose daily, or a double dose – every other day. The high daily dose is divided into 2-4 admission, most of it is taken in the morning.

In acute conditions and as a substitute treatment for adults, it is recommended to start with a dose of 20-30 mg / day; maintenance therapy is carried out at a dose of 5-10 mg / day, some diseases (for example, nephrotic syndrome, individual rheumatic diseases) require higher doses.

Children’s daily doses: initial – 1-2 mg / kg in 4-6 receptions; maintenance – 0.3-0.6 mg / kg. Discontinue treatment gradually, slowly lowering the dose.

If there is a history of psychosis, high-dose therapy is administered under the strict supervision of a specialist. When appointing, the daily secretory rhythm of the GCS is taken into account: in the mornings, the whole dose is taken at a time or a large part of it.

Injection
Prednisolone in the form of a solution is administered intravenously, usually the first injection is done in struyno, and repeated injections are drip. If intravenous administration is impossible for any reason, the solution in the same doses is administered intramuscularly.

Application according to indications:
➲acute adrenal insufficiency: single dose – 100-200 mg; daily – 300-400 mg;
➲severe allergic reactions: daily dose – 100-200 mg, duration of the course – 3-16 days; bronchial asthma: course dose – 75-675 mg, duration of the course – 3-16 days;
➲in severe cases, it is possible to increase the exchange rate to 1400 mg and above;
➲asthmatic status: the starting daily dose is 500-1200 mg followed by a gradual decrease to 300 mg and the transition to maintenance doses;
➲thyrotoxic crisis: 100 mg 2-3 times a day, if necessary daily dose can be increased to 1000 mg;
➲the duration of the course depends on the therapeutic effect and is usually at least 6 days;
➲shock, resistant to standard therapy: the initial dose, as a rule, injected, then transferred to drip infusions;
➲if the blood pressure does not rise within 10-20 minutes, repeat the jet injection. After excretion from the state of shock, drip administration is continued until BP stabilizes. Single dose – 50-150 mg (in severe cases, increase to 400 mg);
➲repeated administration is carried out after 3-4 hours;
➲daily dose varies from 300 to 1200 mg with a further gradual decrease;
➲acute hepatic / renal failure (acute poisoning, postoperative or postpartum periods, etc.): daily dose – 25-75 mg; according to the indications, it is possible to increase it to 300-1500 mg or more;
➲rheumatoid arthritis and SLE: 75-125 mg / day administered for no more than 7-10 days in addition to the systemic intake of Prednisolone;
➲acute hepatitis: daily dose – 75-100 mg, duration of the course – 7-10 days;
➲poisoning with cauterizing liquids, burns of the upper respiratory tract and digestive tract: a daily dose of 75 to 400 mg, depending on the severity of the condition, the duration of the course is 3-18 days.

Do not suddenly stop prolonged therapy with Prednisolone. After relief of acute conditions, they switch to oral administration of the drug in the form of tablets with a gradual dose reduction.

Recommended dosage for children: from 2 to 12 months – at the rate of 2-3 mg / kg; from 1 to 14 years – 1-2 mg / kg; the solution is administered intramuscularly, and when such administration is not possible – intravenously slowly (about 3 minutes). If necessary, you can re-enter the same dose after 20-30 minutes.

Ointment
Ointment is applied externally, applying a thin layer on the affected skin.

To enhance the effect in limited areas, occlusive dressings can be used.
Recommended dosing: apply ointment 1-3 times a day, the duration of the course is, as a rule, 6-14 days; In the process of aftercare, the use of the drug once a day is allowed.

In order to prevent relapse and in the treatment of chronic diseases, the use of ointment continues for some time after the complete disappearance of all symptoms, but no longer than 14 days.
Areas with more dense skin (palms, feet, elbows), as well as places where the ointment is easily washed, can be lubricated more often.

Eye Drops
The drug is buried in the conjunctival sac. The duration of the course is determined by the attending physician.
Standard therapeutic dosing regimen Prednisolone: 1-2 drops 2-4 times a day.

In order to relieve inflammatory symptoms due to trauma to the eyeball, instillation of Prednisolone is recommended to be performed once a day.

Pills, solution for injections
➢endocrine system: impaired glucose tolerance, steroid diabetes / manifestation of latent diabetes, suppression of adrenal cortex function, Itenko-Cushing syndrome (pituitary obesity, lunar face, hirsutism, increased blood pressure, amenorrhea, dysmenorrhea, striae, muscle weakness), delay in puberty in children;
➢digestive system: nausea / vomiting, steroid ulcer of stomach and duodenum, pancreatitis, erosive esophagitis, gastrointestinal perforation / digestion, digestive disorders, increase / decrease in appetite, hiccups, flatulence;
➢rarely – increased activity of hepatic enzymes; cardiovascular system: arrhythmia, development (with predisposition) or increased severity of diagnosed heart failure, characteristic of hypokalemia changes in electrocardiogram indicators, increased blood pressure, bradycardia (up to cardiac arrest), hypercoagulation, thrombosis;
➢with acute and subacute myocardial infarction – proliferation of the focus of necrosis and slowing the formation of scars, which may result in a rupture of the heart muscle;
➢nervous system: headache, dizziness, disorientation, euphoria, delirium, hallucinations, depression, manic-depressive psychosis, paranoia, nervousness or anxiety, increased intracranial pressure, vertigo, insomnia, pseudotumor of the cerebellum, convulsions;
➢sensory organs: increased intraocular pressure (possible damage to the optic nerve), posterior subcapsular cataract, propensity to secondary bacterial, fungal or viral infection of the eye, exophthalmos, trophic corneal pathologies, sudden loss of vision (due to parenteral administration to the neck, head, nasal concha, in the scalp the preparation can crystallize in the vessels of the eye);
➢Metabolism: increased calcium excretion, hypocalcemia, weight gain, increased protein breakdown (negative nitrogen balance), hyperhidrosis;
➢side effects due to mineralocorticoid activity – hypernatremia, peripheral edema as a result of fluid and sodium retention, hypokalemic syndrome manifested by hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue;
➢musculoskeletal: premature closure in children of epiphyseal zones with growth retardation and ossification processes, osteoporosis, steroid myopathy, rupture of muscle tendons, muscular atrophy;
➢very rarely – aseptic necrosis of the head of the hip and humerus, pathological bone fractures;
➢skin and mucous membranes: petechiae, ecchymosis, delayed wound healing, thinning of the skin, hypo- or hyperpigmentation, striae, steroid acne, propensity for pyoderma and candidiasis;
➢hypersensitivity reactions: skin rashes, itching, local allergic reactions, anaphylactic shock; local reactions (parenteral administration): at the injection site – numbness, burning, pain, tingling, infection;
➢rarely – scar formation, necrosis of surrounding tissues;
➢intramuscular injection (especially in the deltoid muscle) – atrophy of the skin and subcutaneous tissue;
➢Other reactions: leukocyturia, development / exacerbation of infections (the simultaneous use of immunosuppressants and vaccination contribute to the occurrence of this side effect), withdrawal syndrome.

Ointment
Possible side effects due to the use of ointment Prednisolone: ​​steroid acne, purpura, telangiectasia, burning, itching, irritation and dry skin.

Prolonged use and / or application of ointment on large surfaces can cause the development of hypercorticism due to the resorptive effect of Prednisolone. In such cases, the drug should be discontinued and consult a specialist.
If these side effects are aggravated or any other reactions not indicated in this manual occur, you should inform your doctor about them.

Eye Drops
After instillation of Prednisolone, a transient burning sensation is possible.
The result of prolonged use may be an increase in intraocular pressure, and therefore preparations containing GCS, use no more than 10 days and under regular control of intraocular pressure.

Continuous use of the eye suspension for 3 months or more can cause the development of a posterolateral cataract.

Overdose
A sign of systemic overdose of Prednisolone is an increase in dose-dependent side effects. It is recommended to carry out symptomatic treatment with a gradual dose reduction, if necessary until the drug is discontinued.
Overdosing with topical application (ointment, eye suspension) can cause local side effects in the form of allergic reactions, the occurrence of which requires immediate withdrawal of the drug.

Special instructions
Before the beginning of therapy, to identify possible contraindications, it is necessary to conduct a clinical examination of the patient, including lung fluoroscopy, examination of the gastrointestinal tract, cardiovascular system, vision and urinary system.

Before the start of treatment and during steroid therapy it is required to regularly monitor general blood counts, the concentration of electrolytes in plasma, the glucose content in urine and blood. Do not vaccinate during the use of GCS, especially in high doses, as its effectiveness will be reduced.

With tuberculosis Prednisolone is prescribed only in combination with anti-tuberculosis drugs. Systemic administration of medium and high doses of the drug may cause an increase in blood pressure. The use of Prednisolone in intercurrent infections associated with septic conditions should be carried out with the support of antibiotic therapy.

Long-term treatment with GCS requires the administration of potassium preparations to avoid hypokalemia. With chronic adrenocortical insufficiency (Addison’s disease) Prednisolone is contraindicated to be taken concomitantly with barbiturates in connection with the danger of the addisonic crisis. In the event of a sudden discontinuation of the drug, especially with high-dose therapy, there is a syndrome of cancellation of the SCS, accompanied by a worsening of appetite, nausea, retardation, generalized musculoskeletal pain, asthenia.

Reduce the likelihood of adrenal insufficiency and associated complications can be, by gradual abolition of Prednisolone. In connection with the fact that adrenal insufficiency after drug cancellation can last for months, any stressful situation in this period requires the resumption of hormone therapy.

The presence of hypothyroidism and / or cirrhosis in the patient may exacerbate the effect of GCS. Patients should be warned in advance about the need for them and their environment to avoid contact with infected measles, herpes and chicken pox. With the current systemic treatment of GCS, or if they have been used in the next 3 months, patients who do not receive vaccination require specific immunoglobulins.

In the case of replacement therapy of adrenal insufficiency due to a weak mineralocorticoid effect, Prednisolone is recommended to be used in combination with mineralocorticoids. When diabetes is required to monitor blood glucose and, if necessary, correction of the dosing regimen. Periodic x-ray control of the osteoarticular system is recommended (photos of hands, spine). In patients with infectious diseases of the kidneys and urinary tract in the latent course, Prednisolone can cause leukocyturia, clinically significant for diagnosis.

GCS increases the metabolites of 11- and 17-oxyketocorticosteroids. Like other local GCS, Prednisolone ointment can not be applied to the skin around the eyes because of the risk of developing glaucoma / cataracts, as well as open wound surfaces. In case of complication of the disease by the development of a secondary fungal or bacterial infection, a specific antibacterial / antimycotic drug should be added to the therapy with Prednisolone.

Drops Prednisolone is not recommended with contact lenses, you should remove the lenses before instillation and wear again not earlier than 15 minutes after the procedure. Long-term use of drops can increase intraocular pressure, so if used for 2 weeks or more, regular monitoring of intraocular pressure is required. SCS therapy can mask the symptoms of a current bacterial / fungal infection, the presence of which is an indication for the use of Prednisolone as part of a complex therapy with antibiotics for topical use.

Influence on ability to manage motor transport and complex mechanisms
According to the instructions, Prednisolone used systemically can cause dizziness and other side reactions that can affect coordination of movements, reaction speed and concentration of attention, so it is not recommended to drive vehicles and maintain mechanical equipment during therapy.

After instillation of Prednisolone suspension, lacrimation is possible, and therefore it is not necessary to carry out the procedure immediately before carrying out potentially hazardous activities. Data on the effects of Prednisolone in the form of an ointment on the ability to drive vehicles and complex mechanisms is not available.

Application in pregnancy and lactation
The use of Prednisolone systemically and topically, in the form of eye drops during pregnancy is possible according to vital indications in case of justifiable excess of the intended benefit for the mother over the potential risk to the fetus.

Long-term systemic therapy of GCS in pregnant women does not exclude the possibility of impaired fetal growth. The use of Prednisolone in the third trimester increases the risk of atrophy of the adrenal cortex of the fetus, so that a newborn may require replacement therapy. Apply Prednisolone topically as short as possible, the ointment should be applied to small areas of the skin surface.

GCS is excreted in breast milk, so when used during breastfeeding it is necessary to take precautions, in particular, not apply ointment on the breast skin shortly before feeding. If you need systemic use of the drug during lactation, or apply to the skin ointment Prednisolone in large doses and / or for an extended period, breast-feeding should be interrupted for the duration of therapy.

Application in childhood
In pediatrics, GCS is used only under absolute indications, under the careful supervision of a physician, since they are capable of causing a slowdown in growth in children and adolescents.

Usually, the risk of developing such side effects helps to avoid or minimize the use of Prednisolone every other day. Children who are in the process of treatment in contact with infected measles or chickenpox require specific immunoglobulins for prevention.

The ratio of the area to the body weight in children is greater than in adults, so they are more at risk of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of hypercortisy syndrome due to the use of any GCS for local use. In infants, diapers, diapers and skin folds can have an effect similar to occlusive dressing, thereby increasing systemic resorption of Prednisolone.

In childhood and adolescence, Prednisolone should be applied at the lowest effective dose, the maximum possible short course, and necessarily under the supervision of a specialist.

For violations of kidney function Tablets and solution
Prednisolone is not prescribed for patients with severe renal failure and with nephrourolythiasis.

For violations of liver function
Tablets and solution Prednisolone is not prescribed for patients with severe hepatic insufficiency.

Application in the elderly
With the use of GCS in the elderly, the incidence of adverse reactions increases.

Drug Interactions
In connection with high pharmacological activity, Prednisolone, like other GCS, can weaken or enhance the action of many drugs / drugs.

If you need to use a solution, tablets or eye drops of Prednisolone in combination with other drugs, the attending physician should consider and take into account their possible interaction. There is no data on the drug interaction of the ointment.

In connection with the possible pharmaceutical incompatibility of the solution of Prednisolone with other drugs administered intravenously, it is recommended to administer it separately: bolus, or through another dropper. Mixing of solutions of Prednisolone and heparin occurs with the formation of a precipitate.

Terms and conditions of storage
Store in a place protected from light and out of reach of children, at a temperature of: tablets – up to 25 ° C, ointment, injection solution – up to 15 ° C, do not freeze the solution; eye drops – 15-25 ° C, open the bottle for 4 weeks.
The shelf life depends on the manufacturer (see the packaging).

Reviews of Prednisolone
According to reviews, Prednisolone in systemic administration (tablets, injections) is quite effective, but patients complain of a large number of side effects. It is difficult to stop receiving after a long course of therapy because of withdrawal syndrome, so you should strictly follow the requirement for a gradual cessation of treatment.
There are complaints about painful injections. It is noted that in emergency cases, parenteral administration of Prednisolone quickly suppresses critical conditions and can save life. Application of the drug in topical forms (ointment, eye drops) practically does not cause side effects, and reviews about them are mostly positive.

Other names for this medication:
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