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Active Ingredient: Propranolol

Other names for this medication:
N-propranolol

Pharmacological action of the drug
Hypotensive, antianginal, antiarrhythmic, uterotonizing.
Blocks beta1 and beta2-adrenergic receptors, has a membrane-stabilizing effect. It reduces the heart rate, reduces the force of the heart and the need for myocardium in oxygen. Reduces cardiac output, renin secretion, arterial pressure, renal blood flow and glomerular filtration rate. After taking a single dose, the hypotensive effect lasts for 20-24 hours. With prolonged use reduces venous return, has a cardioprotective effect.
In patients with moderate form of hypertension – reduces the likelihood of developing IHD and cerebral strokes. With IHD reduces the frequency of seizures, increases the tolerance of physical exertion, reduces the need for nitroglycerin. It is most effective in patients of young age (under 40 years) with hyperdynamic type of circulation and with increased content of renin.
Increases the tone of the bronchi and contractility of the uterus (reduces bleeding during labor and in the postoperative period), increases secretory and motor activity of the gastrointestinal tract. It inhibits platelet aggregation and activates fibrinolysis. Inhibits lipolysis in adipose tissue, preventing the increase in the level of free fatty acids (the concentration of triglycerides in the plasma and the coefficient of atherogenity increase.)
Suppresses glycogenolysis, secretion of glucagon and insulin, the conversion of thyroxine to triiodothyronine .It reduces intraocular pressure, reduces the secretion of watery moisture. and almost completely absorbed from the digestive tract.It is almost completely associated with plasma proteins.Conducts in lung tissue, brain, kidneys, heart, passes through the parade succinic barrier, enters the breast milk. Excreted kidneys as metabolites.

Indications for prescription
Arterial hypertension, angina pectoris, sinus tachycardia (including hyperthyroidism), supraventricular tachycardia, tachysystolic atrial fibrillation, supraventricular and ventricular extrasystole, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, sympathoadrenal crisis in patients with diencephalic syndrome, neurocirculatory dystonia, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prophylaxis), ancillary treatment and pheochromocytoma (only in association with alpha-blockers), thyrotoxicosis (including preoperative) thyrotoxic crisis, primary uterine inertia, menopausal vasomotor symptoms of withdrawal syndrome; treatment of akathisia caused by neuroleptics.

Contraindications
Hypersensitivity, AV blockade of II-III degree, sinoatrial block, bradycardia (less than 55 bpm), sinus node weakness syndrome, arterial hypotension, acute and severe chronic heart failure, Prinzmetal angina, cardiogenic shock, obliterating vascular diseases, bronchial asthma.
For the duration of treatment, breastfeeding should be discontinued.

Restrictions on the use:
☞Chronic bronchitis,
☞emphysema,
☞diabetes mellitus,
☞hypoglycemia,
☞acidosis,
☞impaired liver and kidney function,
☞psoriasis,
☞spastic colitis,
☞myasthenia gravis,
☞elderly age.

Side effects of the drug
➡From the cardiovascular system and blood (hematopoiesis, hemostasis):
☛bradycardia,
☛heart failure,
☛AV blockade,
☛hypotension,
☛violation of peripheral circulation,
☛thrombocytopenic purpura,
☛leukopenia,
☛agranulocytosis.

Interactions
Strengthens (mutually) the negative influence of verapamil and diltiazem on the myocardium, prolongs the action of nondepolarizing muscle relaxants, inhibits the excretion of lidocaine. Weaken the hypotensive effect of NSAIDs, glucocorticoids, estrogens, cocaine; strengthen – nitrates and other antihypertensive drugs. Heparin, antacids lower the level in the plasma; cimetidine and phenothiazines – increase. It is not recommended simultaneous administration with MAO inhibitors. Slows the metabolism of theophylline and increases its concentration in the blood plasma.

Method of application
Inside, squeezed with liquid or semi-liquid food (water, juice, apple puree, pudding), adults: with arterial hypertension – the initial dose – 80 mg twice a day, maintaining a dose of 160-320 mg. Prolonged forms: 80 mg once a day, if necessary up to 120-160 mg once, under the control of blood pressure. At arrhythmias – 10-30 mg 3-4 times a day, with subaortal stenosis – 20-40 mg 3-4 times a day.
With portal hypertension, angina, migraine, excitation, tremor, the initial dose of 40 mg 2-3 times a day, supporting – 160, 120-240, 80-160, 80-120, 80-160 mg / day, respectively. When pheochromocytoma – 30-60 mg / day for 3 days (before surgery). With myocardial infarction – from 5 to 21 days after a heart attack 40 mg 4 times a day for 2-3 days, then – 80 mg 2 times a day.
For the stimulation of labor – 20 mg every 30 minutes 4-6 times (80-120 mg / day), for the prevention of postpartum bleeding – 20 mg 3 times a day for 3-5 days. Children: Inside, the initial dose: 0.5-1 mg / kg / day, supporting – 2-4 mg / kg / day in 2 divided doses.

An overdose of a medicine
Symptoms:
➲dizziness,
➲bradycardia,
➲arrhythmia,
➲heart failure,
➲hypotension,
➲collapse,
➲difficulty breathing,
➲acrocyanosis,
➲convulsions.

➡Treatment: gastric lavage and the appointment of adsorptive agents, symptomatic therapy: atropine, beta-adrenomimetiki (isoprenaline, isadrin), sedatives (diazepam, lorazepam), cardiotonic (dobutamine, dopamine, epinephrine) drugs, vasopressor drugs, glucagon, etc .; it is possible to carry out transvenous stimulation.
Hemodialysis is ineffective.

Other recommendations
Treatment should be carried out under the supervision of a doctor. Reduces compensatory cardiovascular reactions in response to the use of general anesthetics. Intravenous introduction to children is not recommended. In elderly patients, the risk of CNS side effects is increased. When a violation of the liver is recommended to reduce doses. Can mask symptoms of hypoglycemia (tachycardia) in diabetic patients taking insulin and other hypoglycemic drugs. For the duration of treatment, it is recommended to exclude the use of alcoholic beverages. With caution apply during work drivers of vehicles and people whose profession is associated with increased concentration of attention. Stop the treatment gradually, for about 2 weeks. During the treatment, it is possible to change the test results when carrying out laboratory tests (increased levels of urea, transaminases, phosphatases, LDH).

Storage method
List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

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Lasix

Considering high modern levels of consumption of salt which is ingested as a solid part of different foods (chunk food, barbecue, etc.), it is vitally important to get rid of excess “white death” in good time. In this case Lasix comes in handy. A water pill of Lasix will help your body absorb only a small amount of salt it typically needs and not a bit more. Instead of accumulating in your body, excess salt will get out of the body during next urination.
People who suffer from kidney problems (such as nephrotic syndrome), liver conditions or congestive heart failure buy Lasix to treat edema (fluid retention). The medicine can be used for treating hypertension equally well.
The secret lies in an active substance called furosemide. It provides the whole effect.

Where to Buy Lasix?

The next question that may cross your mind after you have already made up your mind to buy Generic Lasix online may be where to buy furosemide. The most convenient thing about this is that you can freely order Lasix without prescription on the Internet at quite an affordable furosemide price. However, you should keep in mind that it is necessary to, first of all, ask your doctor for a piece of advice on your Lasix treatment unless you want unpleasant health consequences. Buy cheap Lasix if you are willing to cleanse your body. You can purchase cheap furosemide online.

Before Your First Lasix Dose

Before starting treatment, you should find out if Lasix is good and safe for you. Your doctor as a qualified medical specialist will help you in that. Prior to buying Generic Lasix without prescription you should be sure of minimal potential risks for your health. These risks may be dangerous and even life-threatening if you do without your doctor’s recommendations. You should discuss your chances of successful treatment if you have any of the following illnesses and conditions:
diabetes;
liver disease (such as cirrhosis);
kidney conditions;
increased levels of cholesterol or triglycerides;
low magnesium or potassium in blood;
different types of urination problems (enlarged prostate, bladder conditions, etc.);
lupus;
gout.
Your doctor is entitled either to change your treatment including dose adjustments and administration frequency or even to prohibit you from taking Lasix if you have any of the above mentioned conditions.
Lasix is not to be used when urination is impossible for some medical or other reasons.
If you have lately had an MRI or any other kind of a scan, you should tell your doctor about that.

Can Pregnant Women Take Lasix?

If you are planning to become pregnant or already pregnant, you should think twice before you buy furosemide online. Lasix belongs to pregnancy category C introduced by FDA. What does this mean? Scientific studies have not yet confirmed or refuted possible harm Lasix may do to an unborn baby.
You should also be careful if you are breast-feeding. Furosemide is reported to be capable of passing into mother’s milk, which may lead to bad health risks and consequences for a nursing baby. A breast feeding woman may also be faced with the risk of milk production slowdown in connection with furosemide.
In any case, you should listen to nobody but your doctor speaking to the point.

How to Take Lasix in a Proper Way?

The medicine is to be taken strictly according to your doctor’s prescription or recommendations. You should agree with the medical specialist on your dosage and frequency of medicine administration. Moreover, your doctor has the right to change your course of treatment in any direction if he finds this appropriate.
You may need to purchase some special pieces of medical equipment such as a medicine cup (a dose-measuring spoon) to measure your doses with. You can find one at the nearest pharmacy. It is strongly recommended that you don’t use a conventional table spoon for this purpose.
Since Lasix will make you urinate oftener, this may be fraught with the complete loss of fluid that means great harm to the body. You should add special potassium supplements and a daily needed amount of salt to your diet to avoid such a sort of problems. However, this all should be done by your doctor’s permission.
During the treatment you should see your doctor for regular blood tests.

What Are Lasix Possible Side Effects?

The following symptoms of an allergic reaction should serve you as a signal to stop your Lasix treatment at once:
swelling;
hives;
difficulty breathing.
You should also cease your treatment if you have any of the following side effects:
hearing loss and other hearing problems;
low potassium or calcium;
weight loss;
pain (in the upper part of stomach, in chest);
headache;
abnormal skin reactions (pale skin, skin pain, etc.).
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If you feel any other symptoms that bother you, seek emergency medical attention immediately.

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