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 Other names for this medication: Alsoben, Arthotec, Artotec, Artrenac, Artrotec, Asotec, Citrosol, Cyprostol, Cytil, Cytofine, Cytolog, Cytomis, Gastrul, Gymiso, Mesopil, Misodex, Misofenac, Misolast, Misolup, Misoprost, Misoprostolum, Misotrol, Noprostol, Normulen, Symbol .

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Active substance: (Misoprostol)

Composition
One tablet of the drug Cytotec contains 200 mcg of misoprostol.
Additional ingredients: castor oil, sodium carboxymethyl cellulose, microcrystalline cellulose, silicon dioxide.

Form release
White Valium tablets notch.
10 tablets in a blister; one, two, five or three blisters in a box made of cardboard or plastic jar.

Pharmachologic effect
Antiulcer action.

Pharmacodynamics and pharmacokinetics:
Pharmacodynamics
Cytotec tablets are antisecretory, anti-ulcer drugs and have also cytoprotectors properties.
Misoprostol is a synthetic analogue of prostaglandin E1, which has a protective effect on the intestinal mucosa and gastric. It improves the stability of the inner membrane of the stomach to the action of negative factors: malnutrition, alcohol, stress, non-steroidal anti-inflammatory agents; helps prolong peptic ulcers, stops the occurrence of erosive and ulcerative disorders.
Cytoprotective effect of the drug is associated with an increase in mucus production in the stomach and increase its own gastric mucosal bicarbonate secretion. The drug has also antisecretory activity, reacting with receptors of prostaglandin E-type. It has a direct effect on the cells of the stomach, slows down the night, both basal and stimulated secretion of hydrochloric acid, and reduces the amount of proteolytic activity of gastric juice. It weakens the basal production of endogenous pepsin. It increases blood flow to the stomach. The drug begins half an hour after administration and lasts a minimum of 3 hours. The effect has a pronounced dose-dependent. It increases strength and frequency of contractions of the myometrium and the muscles of the intestine.

Pharmacokinetics
Rapidly absorbed (food intake slows absorption). The walls of the intestine and the liver to form biotransformed misoprostol pharmacologically active misoprostol acid. The largest concentrations are in about 12 minutes, it circulates in the bloodstream in a complex with proteins (90%). The half-life time may be up to 40 minutes. The equilibrium concentration of active substance in the blood is reached after 2 days, accumulation is not observed. Up to 80% of the dose is excreted by the kidneys, in violation of their operation may increase the half-life and an increase in the maximum concentration of 2 times.

Indications
Treatment and prevention of gastric mucosal lesions and 12 duodenal ulcer, ulcerative erosive nature, caused by including taking anti-inflammatory non-steroidal agents.
Medication abortion (medical abortion in most countries the drug is used without authorization and without the need for patient information on safe use).

Contraindications
Cardiovascular disease.
Hypersensitivity to the drug.
Liver and kidneys.
Endocrinopathies and destruction of the endocrine system.
Diseases associated with dependence on prostaglandins.
Anemia.
Hormone-dependent tumors.
Lactation.
Age up to 18 years.
Suspected ectopic pregnancy.
The use of intrauterine contraceptive devices.
Pregnancy (if the drug is not used for the purpose of an interruption).

Side effects
Frustration on the part of digestion: stomach pain, vomiting, diarrhea, dyspepsia, nausea, flatulence, constipation.
Disorders of the reproductive sphere: pain in the lower abdomen floor hypermenorrhoea, dysmenorrhea, postmenopausal vaginal discharge bloody nature.
Other disorders: headaches, cramps in women paraklimaktericheskom period, asthenia, fatigue, weight change, rashes.

Instructions for use (Method and Dosage)
Instructions on Cytotec provides a use of the drug for the treatment and prevention of peptic ulcer disease and does not spread the recommendations on the use of funds for abortion. The drug is taken orally with meals. To treat ulcers caused by the use of nonsteroidal anti-inflammatory agents, manual prescribes Cytotec take 800 mg of the drug twice a day for 1-2 months.
For the prevention of ulcers caused by the use of non-steroidal anti-inflammatory agents, medicine taking 200 mg 2-4 times a day during the treatment period, non-steroidal anti-inflammatory agents.
Cytotec Abortion
Use for abortion up to 63 days only in combination with mifepristone, trained personnel in institutions with the ability to provide emergency assistance. In the later stages of the drug ineffective.

Overdose
No data on misoprostol toxicity in humans. Symptoms indicating excess dosage: drowsiness, bradycardia, seizures, tremor, abdominal pain, palpitations, fever, hypotension.

Interaction
When used together with antacids decreases the concentration of active substance in the blood.
When using a magnesium-containing antacids can not be ruled strengthening diarrhea.
In a joint application with diclofenac, or indomethacin stimulated side effects of the latter.

Storage conditions
Store in a dry place at temperatures up to 30 ° C. Keep away from children.

Shelf life
3 years.

Special instructions
The drug should be used with caution in patients with coronary heart disease, arterial hypertension, cerebral circulatory disorders, diarrhea, epilepsy, koronarokardiosklerozom, enterocolitis, hypersensitivity to prostaglandins.
In appointing the patients of childbearing age must first carry out a pregnancy test. The test should be negative for 2 weeks prior to application of the drug. Treatment is allowed to start only 2 days after the start of menstruation. Throughout the period of the reception should use reliable methods of contraception. Misoprostol increases uterine tone and can trigger a miscarriage.

For Kids
Do not use in patients under 18 years.

During pregnancy (and lactation)
The product may not be used during these periods with the exception of applications for the purpose of termination of pregnancy.
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